Neurochemical Modulation in Posteromedial Default-mode Network Cortex Induced by Transcranial Magnetic Stimulation

Vidal-Piñeiro, Dídac; Martin-Trias, Pablo; Falcón, Carles; Bargalló, Núria; Clemente, Imma C.; Valls‐Solé, Josep; Junqué, Carme; Pascual‐Leone, Álvaro; Bartrés‐Faz, David

doi:10.1016/j.brs.2015.04.005

Cited by 43 publications

(40 citation statements)

References 81 publications

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“…- Neuroscience Evidence: “Glutamate and GABA neurotransmitters have a basic role in neuroplasticity and their concentration mediates activation and deactivation of large-scale networks in the brain (Vidal-Piñeiro et al, 2015). Dysfunction of neuroplasticity and glutamate/GABA microcircuits within the default mode network are reported in the disorder X”.…”

Section: Towards Individualized Tes Interventionsmentioning

confidence: 99%

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Transcranial Electric Stimulation for Precision Medicine: A Spatiomechanistic Framework

Yavari

Nitsche

Ekhtiari

2017

Front. Hum. Neurosci.

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During recent years, non-invasive brain stimulation, including transcranial electrical stimulation (tES) in general, and transcranial direct current stimulation (tDCS) in particular, have created new hopes for treatment of neurological and psychiatric diseases. Despite promising primary results in some brain disorders, a more widespread application of tES is hindered by the unsolved question of determining optimum stimulation protocols to receive meaningful therapeutic effects. tES has a large parameter space including various montages and stimulation parameters. Moreover, inter- and intra-individual differences in responding to stimulation protocols have to be taken into account. These factors contribute to the complexity of selecting potentially effective protocols for each disorder, different clusters of each disorder, and even each single patient. Expanding knowledge in different dimensions of basic and clinical neuroscience could help researchers and clinicians to select potentially effective protocols based on tES modulatory mechanisms for future clinical studies. In this article, we propose a heuristic spatiomechanistic framework which contains nine levels to address tES effects on brain functions. Three levels refer to the spatial resolution (local, small-scale networks and large-scale networks) and three levels of tES modulatory effects based on its mechanisms of action (neurochemical, neuroelectrical and oscillatory modulations). At the group level, this framework could be helpful to enable an informed and systematic exploration of various possible protocols for targeting a brain disorder or its neuroscience-based clusters. Considering recent advances in exploration of neurodiversity at the individual level with different brain mapping technologies, the proposed framework might also be used in combination with personal data to design individualized protocols for tES in the context of precision medicine in the future.

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Section: Towards Individualized Tes Interventionsmentioning

confidence: 99%

“…- Stimulation Evidence: “MRS imaging has revealed the ability of excitatory Theta burst stimulation over the left inferior parietal lobule, one of the default mode network nodes, to modulate GABA within this network (Vidal-Piñeiro et al, 2015)”.…”

Section: Towards Individualized Tes Interventionsmentioning

confidence: 99%

Transcranial Electric Stimulation for Precision Medicine: A Spatiomechanistic Framework

Yavari

Nitsche

Ekhtiari

2017

Front. Hum. Neurosci.

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“…However, these considerations are very preliminary, since the above studies did not measure GABA concentrations [58, 74]. The only study specifically investigating parietal after-effects of excitatory stimulation over both GABA and Glx used TBS and was aimed at DMN stimulation through the left IPL [78]. Inhibitory TBS induced distal GABA increases in the posteromedial DMN areas, with no local change in GABA or Glu [78].…”

Section: Mechanisms Of Network Modulation: Brain Neurometabolitesmentioning

confidence: 99%

“…The only study specifically investigating parietal after-effects of excitatory stimulation over both GABA and Glx used TBS and was aimed at DMN stimulation through the left IPL [78]. Inhibitory TBS induced distal GABA increases in the posteromedial DMN areas, with no local change in GABA or Glu [78]. Moreover, increments in distal GABA concentration were significantly related to baseline FC between the stimulated site and the posteromedial cortex, while nonsignificant Glx modulation after iTBS was inversely related to FC, suggesting that baseline connectivity patterns predict neurotransmitter modulation in distal areas.…”

Section: Mechanisms Of Network Modulation: Brain Neurometabolitesmentioning

confidence: 99%

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

et al. 2018

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Non-invasive brain stimulation (NIBS) is emerging as a promising rehabilitation tool for a number of neurodegenerative diseases. However, the therapeutic mechanisms of NIBS are not completely understood. In this review, we will summarize NIBS results in the context of brain imaging studies of functional connectivity and metabolites to gain insight into the possible mechanisms underlying recovery. We will briefly discuss how the clinical manifestations of common neurodegenerative disorders may be related with aberrant connectivity within large-scale neural networks. We will then focus on recent studies combining resting-state functional magnetic resonance imaging with NIBS to delineate how stimulation of different brain regions induce complex network modifications, both at the local and distal level. Moreover, we will review studies combining magnetic resonance spectroscopy and NIBS to investigate how microscale changes are related to modifications of large-scale networks. Finally, we will re-examine previous NIBS studies in dementia in light of this network perspective. A better understanding of NIBS impact on the functionality of large-scale brain networks may be useful to design beneficial treatments for neurodegenerative disorders.

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“…However, theta burst stimulation (a variation of high-frequency rTMS) can either depress (continuous) or facilitate (intermittent) cortical excitability, depending on burst-train duration (Mix et al, 2010). In addition to modulating cortical excitability, rTMS has also been shown to modify the blood flow in the target area (Bestmann et al, 2005), the frequency of neuronal discharge (Barr et al, 2009), and of the release of neurotransmitters, including dopamine (Strafella et al, 2001;Strafella et al, 2003;Cho & Strafella, 2009), GABA (Stagg et al, 2009;Vidal-Piñeiro et al, 2015;Iwabuchi et al, 2017) and glutamate (Michael et al, 2003). Repetitive TMS may act not only locally, but also remotely on deeper structures, via brain circuits and interhemispheric connections (Fox et al, 1997).…”

Section: Stress-induced Craving In Gdmentioning

confidence: 99%

Neural correlates of cue‐ and stress‐induced craving in gambling disorders: implications for transcranial magnetic stimulation interventions

Spagnolo

Pérez²,

Terraneo³

et al. 2019

Eur J of Neuroscience

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Gambling disorder (GD), currently considered a behavioral addiction, shows substantial similarities with substance use disorders (SUDs) in terms of neurobiology and phenomenology. These similarities have been recognized in the DSM‐5, although several relevant differences still exist in the diagnostic criteria, in particular, with regard to the role of cue‐ and stress‐ induced craving. Craving, recently included as a new criterion for SUDs diagnosis only, is a key construct also in the pathophysiology of GD. Furthermore, brain imaging studies indicate that similar alterations in cortico‐limbic‐striatal and prefrontal control circuits underlie the emergence of craving states in both disorders. This has important implications for the identification of neurobiologically based anti‐craving interventions, which may be used for both GD and SUDs. In this regard, a novel neuromodulation intervention, named repetitive transcranial magnetic stimulation (rTMS), is emerging as a promising treatment for craving in SUDs, and could potentially be effective also in treating gambling urges. Here, we review the clinical neurobiological research on GD, with a specific emphasis on the neural circuits implicated in cue‐ and stress‐craving, taking SUDs as the major comparative example. Furthermore, we describe the studies that have evaluated rTMS as a therapeutic tool for targeting and restoring the neural alterations underlying gambling urge. The manuscript concludes discussing some of the limitations of the current studies, and suggests directions for future rTMS research in GD.

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Neurochemical Modulation in Posteromedial Default-mode Network Cortex Induced by Transcranial Magnetic Stimulation

Cited by 43 publications

References 81 publications

Transcranial Electric Stimulation for Precision Medicine: A Spatiomechanistic Framework

Transcranial Electric Stimulation for Precision Medicine: A Spatiomechanistic Framework

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

Neural correlates of cue‐ and stress‐induced craving in gambling disorders: implications for transcranial magnetic stimulation interventions

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