Neurocardiac Responses to Vagoafferent Electrostimulation in Humans

Kamath, M.V.; Upton, A.R.M.; Talalla, Andrew; Fallen, Ernest L.

doi:10.1111/j.1540-8159.1992.tb02937.x

Cited by 48 publications

(29 citation statements)

References 15 publications

(1 reference statement)

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“…21 22 The same stimuli also elicit reproducible cerebral evoked responses 23. We have reported similar cerebral evoked responses and increased vagal efferent activity with direct electrostimulation of the left cervical vagus 23…”

Section: Discussionmentioning

confidence: 53%

Cardiac autonomic function and oesophageal acid sensitivity in patients with non-cardiac chest pain

Tougas¹,

Spaziani²,

Hollerbach³

et al. 2001

Gut

101

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Background-Acid reflux can elicit noncardiac chest pain (NCCP), possibly through altered visceral sensory or autonomic function. The interactions between symptoms, autonomic function, and acid exposure are poorly understood. Aim-To examine autonomic function in NCCP patients during exposure to oesophageal acid infusion. Subjects and methods-Autonomic activity was assessed using power spectral analysis of heart rate variability (PSHRV), before and during oesophageal acidification (0.1 N HCl), in 28 NCCP patients (40.5 (10) years; 13 females) and in 10 matched healthy controls. Measured PSHRV indices included high frequency (HF) (0.15-0.5 Hz) and low frequency (LF) (0.06-0.15 Hz) power to assess vagal and sympathetic activity, respectively. Results-A total of 19/28 patients had angina-like symptoms elicited by acid. There were no significant manometric changes observed in either acid sensitive or insensitive patients. Acid sensitive patients had a higher baseline heart rate (82.9 (3.1) v 66.7 (3.5) beats/min; p<0.005) and lower baseline vagal activity (HF normalised area: 31.1 (1.9)% v 38.9 (2.3)%; p< 0.03) than acid insensitive patients. During acid infusion, vagal cardiac outflow increased (p<0.03) in acid sensitive but not in acid insensitive patients. Conclusions-Patients with angina-like pain during acid infusion have decreased resting vagal activity. The symptoms elicited by perception of acid are further associated with a simultaneous increase in vagal activity in keeping with a vagally mediated pseudoaVective response. (Gut 2001;49:706-712)

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Section: Discussionmentioning

confidence: 53%

Cardiac autonomic function and oesophageal acid sensitivity in patients with non-cardiac chest pain

Tougas¹,

Spaziani²,

Hollerbach³

et al. 2001

Gut

101

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show abstract

“…Among them, the spectral analysis of heart rate variability is a reliable non-invasive method to obtain a marker of the autonomic nervous system activity (Heathers, 2014; Task Force of the European Society of Cardiology the North American Society of Pacing Electrophysiology, 1996). More specifically, the high frequency component of heart rate variability (HF-HRV) is a good marker of the vagal parasympathetic activity (Akselrod et al, 1981;Gary G Berntson et al, 1997;Gary G Berntson, Cacioppo, & Quigley, 1993;Gary G. Berntson, Norman, Hawkley, & Cacioppo, 2008; J. T. Cacioppo et al, 1994;Kamath & Fallen, 1993;Kamath, Upton, Talalla, & Fallen, 1992), providing a rigorous assessment the myelinated heart-brain connection activity.…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Resting high frequency heart rate variability selectively predicts cooperative behavior

Beffara

Bret

Vermeulen

et al. 2016

Physiology & Behavior

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“…Kamath et al [25] assessed HRV in a group of epileptic patients who underwent VNS either at 30-Hz frequency and 500-ms pulse width (high stimulation group) or at 2-Hz frequency and 130-ms pulse width (low stimulation group). HRV was measured on 3 ECG recordings of 45 min every 8 h, at baseline and after 15 days from the im- plantation of a vagal stimulator.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vagal Nerve Stimulation on Systemic Inflammation and Cardiac Autonomic Function in Patients with Refractory Epilepsy

Barone

Colicchio

Policicchio

et al. 2007

Neuroimmunomodulation

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Objective: Recent data suggest that vagus nerve stimulation (VNS) can inhibit cytokine release by inflammatory cells. Accordingly, an association between impaired cardiac parasympathetic function, as assessed by heart rate variability (HRV), and increased markers of inflammation has recently been reported. In this study we assessed the effect of direct left VNS on inflammatory markers and HRV in patients with refractory epilepsy. Methods: A 24-hour electrocardiogram Holter recording was performed both at baseline and after 3 months of left VNS in 8 patients (age 32 ± 24 years, 2 men) who underwent implantation of a VNS device because of refractory epilepsy. Tumor necrosis factor-α, interleukin-6 and C-reactive protein serum levels were measured, as markers of inflammation, at the same times. Results: No significant changes were found after 3 months of left VNS, compared to baseline, both for HRV variables and inflammatory markers. Also, no consistent correlation could be demonstrated between HRV parameters and inflammatory markers in these patients. Conclusions: Our data in epileptic patients without cardiovascular disease failed to show a significant effect of left VNS on cardiac autonomic function and on systemic inflammation at short-term follow-up.

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Neurocardiac Responses to Vagoafferent Electrostimulation in Humans

Abstract: (1) A relationship exists between selective vagal nerve electrostimulation and the HRA; and (2) high stimulation frequency of the vagus nerve in man is associated with sustained augmentation of cardiac vagal tone throughout a 24-hour cycle.

Cited by 48 publications

References 15 publications

Cardiac autonomic function and oesophageal acid sensitivity in patients with non-cardiac chest pain

Cardiac autonomic function and oesophageal acid sensitivity in patients with non-cardiac chest pain

Resting high frequency heart rate variability selectively predicts cooperative behavior

Effect of Vagal Nerve Stimulation on Systemic Inflammation and Cardiac Autonomic Function in Patients with Refractory Epilepsy

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