Neurobrucellosis presenting as an intra-medullary spinal cord abscess

Vajramani, Girish; Nagmoti, Mahantesh B; Patil, C. S.

doi:10.1186/1476-0711-4-14

Cited by 38 publications

(12 citation statements)

References 8 publications

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“…The most common infectious organism is B. melitensis [15]. Brucellosis can affect the nervous system because of a direct effect of bacilli, cytokines or endotoxins on peripheral nerves, the spinal cord, meninges and the brain [6, 16, 17]. It is postulated that the pathogenesis of this involvement may differ, being a direct infection in the acute form and an immune-related, possibly demyelinating process in the chronic forms [6, 12, 17].…”

Section: Discussionmentioning

confidence: 99%

Brucella: A Cause of Peripheral Neuropathy

et al. 2008

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Brucellosis is a common infectious disease in Mediterranean countries. We evaluated the peripheral nerve involvement in patients with brucellosis. Thirty-eight patients with brucellosis were examined. Four of them were excluded because of B₁₂ deficiency and diabetes mellitus. Thirty-four patients were included. The average age was 43.08 ± 15.3 years. Patients were divided into two groups according to the abnormality in their peripheral nervous system (PNS) examination. All patients underwent nerve conduction and needle electromyography EMG studies. Twenty normal healthy subjects were used as a control group. Axonal sensorimotor neuropathy was determined in 12 patients who also had abnormality in PNS examination. After 6 months of treatment, nerve conduction studies were nearly normal in these patients. The EMG findings of the remaining 22 patients were normal, as well as the clinical examination. However, the motor conduction velocities of median (p < 0.001), peroneal (p < 0.001), and ulnar (p < 0.05) nerves were decreased, F wave latencies were prolonged in the posterior tibial and peroneal nerve, and distal latency was also prolonged in the posterior tibial nerve (p < 0.05) when compared to healthy subjects. Sensory conduction velocities of the median (p < 0.001), ulnar and sural (p < 0.05) nerve were also decreased. Brucellosis may be considered as a cause of clinical or subclinical peripheral neuropathy and should be evaluated especially in endemic areas.

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Section: Discussionmentioning

confidence: 99%

Brucella: A Cause of Peripheral Neuropathy

et al. 2008

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“…The duration of treatment depends on the severity of neurological involvement. In this review, we specifically discuss the neurological involvement of human brucellosis as per case reports from the developing country of India, where neurobrucellosis is rarely reported [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Neurological Manifestations of Brucellosis in an Indian Population

Tarfarosh

Manzoor

2016

Cureus

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Brucellosis is a zoonotic disease causing serious public health problems in countries of the Middle-East and developing countries like India. Neurobrucellosis is one of the devastating complications of this re-emerging zoonosis. The objective of this review was to identify the neurological manifestations of Brucellosis in an Indian population and bring into light the effective modalities used for treating neurobrucellosis. A systematic review of the scientific literature reported in accordance with the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines was conducted. Three databases (PubMed, IndMed, and ScienceDirect) were used to analyze retrospectively case reports of sufficient quality for data extraction (from the last 15 years, 2002-2016), and relevant literature was reviewed. Most of the cases had a definite history of exposure to Brucella through occupational contact with cattle, drinking raw milk, or living near unhygienic abattoir or even trips to epidemic areas outside India. The common presentations include fever, meningitis, brisk deep-tendon reflexes, extensor plantars, sensory deficit usually below the twelfth thoracic vertebral level, weakness of lower limbs, ocular signs of papilledema, and retrobulbar neuritis. The usual systemic findings associated were hepatosplenomegaly and weight-loss. Neurobrucellosis needs to be kept in mind in the differential diagnosis of fever of unknown origin involving neurological symptoms and systemic involvement. Prognosis is good if there is a combination of antibiotics, each with different mechanisms of action given in full dose. Suitable measures for its prevention are also suggested.

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“…Ancak nörolojik sekel kalıcı olabilmektedir. Morbiditenin azaltılması, bulgular kronikleşmeden tanı konarak uygun tedavinin başlanması ile mümkündür (16).…”

Section: Olguunclassified

A case of neurobrucellosis

Okuyucu¹,

Yilmazer²,

Dede³

et al. 2011

Türk Beyin Damar Hast Derg

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Brusella, klinik önemi morbiditesinin ağırlığından ve pek çok farklı klinik formda ortaya çıkabilmesinden kaynaklanan bulaşıcı bir hastalıktır. Nörobruselloz; kranial sinir patolojileri, optik staz, menenjit, myelit, radikulopati, periferik nöropati tabloları görülebilir ya da klinik tablo değişik kombinasyonlarla şekillenebilir. Olgumuzun, 69 yaşında bayan hasta, şikayetleri 3 yıl önce bel ağrısı ile başlamış. Son 1 yıldır ayakta desteksiz duramamaktaydı. Kranial MRI'da bilateral periventriküler beyaz cevherde kronik iskemik değişiklikler, sağ serebellar hemisferde ansefalomalezik alan saptandı. Hastanın tanıya yönelik araştırmalarında Brusella tüp agglütinasyon 1/160 (+) olarak bulundu. Nörobruselloza yönelik tedavi sonucunda klinik düzelme gözlemlendi. Nörobruselloz, farklı klinik formlarda kendini gösterebilen bir çok durumun ayırıcı tanısında dikkate alınması gereken bir klinik tablodur.

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Neurobrucellosis presenting as an intra-medullary spinal cord abscess

Abstract: Background: Of the diverse presentation of neurobrucellosis, intra-medullary spinal cord abscess is extremely rare. Only four other cases have been reported so far. We present a case of spinal cord intra-medullary abscess due to Brucella melitensis.

Cited by 38 publications

References 8 publications

Brucella: A Cause of Peripheral Neuropathy

Brucella: A Cause of Peripheral Neuropathy

Neurological Manifestations of Brucellosis in an Indian Population

A case of neurobrucellosis

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