Neurobiological Substrates of Electroconvulsive Therapy for Tourette Syndrome

Morais, S. L.; Derenusson, Guilherme Nogueira; Pinto, José Roberto Aparecido dos Santos; Hounie, Ana Gabriela; Dursun, Serdar; Wichert‐Ana, Lauro; Kato, Mery; Oliveira, Lucas Ferrari de; Azevedo-Marques, Paulo Mazzoncini de; Sakamoto, Américo Ceiki; Hallak, Jaime Eduardo Cecílio

doi:10.1097/yct.0b013e31811f354c

Cited by 9 publications

(7 citation statements)

References 16 publications

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“…8 Electroconvulsive therapy is a noninvasive electrical stimulation therapy that influences cortical excitability. 11,12,14 These strong comorbidities clearly reduced the conclusiveness of a specific efficacy of ECT, although it was considered an effective treatment for the therapyrefractory GTS symptoms in 6 of the patients. The 7 reports on GTS and ECT (Table 1) 9Y15 in the literature noted that 5 of the 7 patients suffered not only from GTS but also from psychotic symptoms 10,15 or depression.…”

Section: Discussionmentioning

confidence: 99%

“…14 Tardive GTS + MD 1 59 M 4Â bilateral, 6Â unilateral Total resolution of a severe motor tic Rapoport 12 GTS + MD 1 37 F 8Â unilateral Tics were in full remission Trivedi 15 GTS + catatonia 1 64 F 6Â bilateral Tics responded rapidly Strassnig 13 GTS 1 39 F 9Â unilateral, 12Â M-ECT Remarkably positive effects on tic symptoms Karadenizli 10 GTS + auditory hallucinations 1 28 M 7Â bilateral A 2-year remission in symptoms Morais 11 GTS + MD 1 27 M 15Â bilateral, 8Â M-ECT Complete remission of tics and depression As a first step, controlled studies with short-term and long-term observation of patients with GTS are required to ensure the efficacy of this well-tolerated and noninvasive treatment in this special patient group.…”

Section: Discussionmentioning

confidence: 99%

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Long-Term Results of Electroconvulsive Therapy in Severe Gilles de la Tourette Syndrome

Dehning

Feddersen²,

Mehrkens³

et al. 2011

The Journal of ECT

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To avoid chronic distress and increasing social isolation, patients with severe, medication-resistant Gilles de la Tourette syndrome (GTS) require treatment alternatives. Electroconvulsive therapy (ECT) is such an alternative treatment, which, however, is rarely mentioned in the literature: a Pubmed search revealed only 7 reports on GTS and ECT, and there were no long-term data on continuously applied maintenance ECT in GTS. This report is the first to document a 5-year-long, full remission from severe GTS after long-term ECT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Long-Term Results of Electroconvulsive Therapy in Severe Gilles de la Tourette Syndrome

Dehning

Feddersen²,

Mehrkens³

et al. 2011

The Journal of ECT

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“…Improvement rates between 83-100% were reported; thus, all four patients achieved clinical response [44][45][46][47]. Qualitative follow-up outcomes were reported in three cases: all experienced complete remission with no relapse up to 8 months following treatment [44][45][46], yet no studies reported quantitative (i.e., YGTSS) outcomes at follow-up. Depression outcomes were not reported, despite two patients reportedly experiencing comorbid depression.…”

Section: Ect Results For Tsmentioning

confidence: 99%

Therapeutic Neurostimulation in Obsessive-Compulsive and Related Disorders: A Systematic Review

et al. 2021

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Invasive and noninvasive neurostimulation therapies for obsessive-compulsive and related disorders (OCRD) were systematically reviewed with the aim of assessing clinical characteristics, methodologies, neuroanatomical substrates, and varied stimulation parameters. Previous reviews have focused on a narrow scope, statistical rather than clinical significance, grouped together heterogenous protocols, and proposed inconclusive outcomes and directions. Herein, a comprehensive and transdiagnostic evaluation of all clinically relevant determinants is presented with translational clinical recommendations and novel response rates. Electroconvulsive therapy (ECT) studies were limited in number and quality but demonstrated greater efficacy than previously identified. Targeting the pre-SMA/SMA is recommended for transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS). TMS yielded superior outcomes, although polarity findings were conflicting, and refinement of frontal/cognitive control protocols may optimize outcomes. For both techniques, standardization of polarity, more treatment sessions (>20), and targeting multiple structures are encouraged. A deep brain stimulation (DBS) ‘sweet spot’ of the striatum for OCD was proposed, and CBT is strongly encouraged. Tourette’s patients showed less variance and reliance on treatment optimization. Several DBS targets achieved consistent, rapid, and sustained clinical response. Analysis of fiber connectivity, as opposed to precise neural regions, should be implemented for target selection. Standardization of protocols is necessary to achieve translational outcomes.

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“…There has been limited data on the effects of ECT on patients with Tourette's syndrome or other tic-like disorders. During this review, there were eight case reports of patients with tic-like disorders, including Tourette's, being treated with ECT [47][48][49][50][51][52][53][54]. There was a positive effect of ECT in all cases regardless of lead placement, such as a two-year remission after seven ECT sessions [49], the elimination of any symptoms of Gilles de la Tourette's syndrome for five months after ECT [52], and the resolution of symptomology in a patient who suffered both from obsessive-compulsive disorder and Tourette's syndrome [54].…”

Section: Tourette's and Other Tic-like Disordersmentioning

confidence: 99%

Efficacy of Electroconvulsive Therapy for the Treatment of Movement Disorders: A Literature Review

Nazar¹,

Brooks²,

Chatham³

et al. 2023

Cureus

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Electroconvulsive therapy (ECT) is a safe and effective treatment modality for various psychiatric disorders. However, evidence suggests a putative role of ECT in treating movement disorders that are refractory to less invasive modalities. ECT is primarily used in treatment-resistant psychiatric disorders. However, growing evidence exists for its use in movement disorders with and without psychiatric comorbidity.The primary objective of this systematic review was to examine the efficacy of ECT as a primary treatment modality for movement disorders. Relevant, peer-reviewed publications were retrieved from PubMed, SCOPUS, CINAHL, and PsycINFO. Keywords related to ECT and movement disorders were used as search phrases to identify relevant articles. A total of 90 articles that met the inclusion criteria were included in this review. Core findings were subsequently appraised on the role of ECT in treating movement disorders.Inclusion and exclusion criteria were developed to guide the search and selection process. Sources that met the inclusion criteria were those published between 2001 and January 2023. Additionally, peer-reviewed journals published in the English language covering the role of ECT in movement disorders were deemed appropriate for inclusion. Sources published before 2001, written in a non-English language, and not from peer-reviewed journals were excluded from this systematic review. The exclusion criteria also entailed eliminating duplicates from the review list.Most reviewed sources revealed that ECT improved outcomes in symptoms associated with various movement symptoms. However, ECT does not have a long-lasting impact on neuroacanthocytosis symptoms. Additionally, ECT is negatively associated with aggression and agitation, two of the most critical movement symptoms of Alzheimer's disease.Evidence affirms the efficacy of ECT in providing symptomatic relief for movement disorders aside from psychiatric comorbidities. This positive association highlights the need for randomized controlled studies to identify movement disorder sub-populations that may respond to ECT.

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Neurobiological Substrates of Electroconvulsive Therapy for Tourette Syndrome

Cited by 9 publications

References 16 publications

Long-Term Results of Electroconvulsive Therapy in Severe Gilles de la Tourette Syndrome

Long-Term Results of Electroconvulsive Therapy in Severe Gilles de la Tourette Syndrome

Therapeutic Neurostimulation in Obsessive-Compulsive and Related Disorders: A Systematic Review

Efficacy of Electroconvulsive Therapy for the Treatment of Movement Disorders: A Literature Review

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