Neurobiological mechanisms of nicotine craving

Miyata, Hisatsugu; Yanagita, Tomoji

doi:10.1016/s0741-8329(01)00144-6

Cited by 29 publications

(22 citation statements)

References 53 publications

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“…The scientific community has been promoting the debate on the role of craving as one of the most important triggering factors of lapses and relapses in substance-dependent individuals, 36 and, more specifically, in nicotine-dependent subjects. 5 Therefore, it is extremely important to study the coping strategies for craving management, [14][15][16][17][18] as well as the factors related to these strategies.…”

Section: Discussionmentioning

confidence: 99%

Coping strategies for craving management in nicotine dependent patients

Araújo¹,

Oliveira

Pedroso

et al. 2009

Rev. Bras. Psiquiatr.

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Section: Discussionmentioning

confidence: 99%

Coping strategies for craving management in nicotine dependent patients

Araújo¹,

Oliveira

Pedroso

et al. 2009

Rev. Bras. Psiquiatr.

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“…Of significance is the finding that in the repeated reinstatement tests, cue-induced reinstatement of nicotine-seeking was obtained only at the two highest doses of nicotine. The explanation for the difference between higher nicotine dose groups and the lower one may reside in neuroadaptive changes that accrue after chronic high level of nicotine exposure (Ochoa et al 1990;Miyata and Yanagita 2001;Rahman et al 2004). For example, it has been found that after 25 daily 1-h nicotine (0.03 mg/kg/infusion) self-administration sessions, rats had decreased basal dopamine levels in the nucleus accumbens and a blunted dopamine increase in response to nicotine challenge (Rahman et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Cue-induced reinstatement of nicotine-seeking behavior in rats: effect of bupropion, persistence over repeated tests, and its dependence on training dose

et al. 2007

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Rationale-The motivational effects of nicotine-associated cues have been demonstrated in animal studies. However, it is unknown whether the effectiveness of nicotine cues in reinstating nicotineseeking varies with the extent of prior nicotine self-administration. In addition, the issue of whether bupropion (an FDA-approved smoking cessation medication) interferes with the conditioned incentive of nicotine cues remains to be addressed.Objective-This study determined the relationship of cue-reinstated nicotine-seeking and the levels of prior self-administration and examined the effect of bupropion on cue-induced reinstatement of nicotine-seeking in comparison with that on self-administration. Materials and methods-MaleSprague-Dawley rats were trained in daily 1-h sessions to intravenously self-administer nicotine at different doses (0, 0.015, 0.03, 0.06 mg/kg/infusion) and to associate an auditory/visual cue with each nicotine delivery. After extinction, three reinstatement tests at 15 day intervals were conducted with re-presentation of the cue without nicotine delivery. In separate groups of rats trained with 0.03 mg/kg/infusion nicotine, bupropion (0, 10, 20, 40 mg/kg) was intraperitoneally administered to different groups before the reinstatement and in a withinsubject design before the self-administration tests.Results-Cue-induced reinstatement of active lever responses was observed at all nicotine doses in the first reinstatement test, but at only the two highest doses during the second and third tests. The magnitude of reinstatement was positively correlated with level of prior responding for nicotine. Bupropion pretreatment decreased nicotine self-administration but enhanced cue-reinstated nicotineseeking.Conclusions-These results demonstrate the positive correlation of cue-reinstated nicotineseeking with prior responding for nicotine self-administration and the persistence of the cue effect after taking higher doses of nicotine. The results of pharmacological tests suggest that although it is able to help achieve smoking cessation, bupropion may have little clinical benefit for the prevention of relapse associated with exposure to environmental smoking cues.

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“…For example, psychostimulant drugs, such as amphetamine, nicotine, and cocaine, lead to increases in dendritic arborization and spine density in the nucleus accumbens (NAcc) and prefrontal neocortex (Brown & Kolb, 2001;Kolb, Gorny, Li, Samaha, & Robinson, 2003;Robinson & Kolb, 1997, 1999), brain regions thought to be involved in stimulant addiction (Pich et al, 1997) and craving (Miyata & Yanagita, 2001). These drug-induced modifications in dendritic structure may offer some insight into the puzzling pattern of cognitive impairments associated with the cessation of psychostimulant use in addicts.…”

mentioning

confidence: 99%

Differential Effects of Nicotine and Complex Housing on Subsequent Experience-Dependent Structural Plasticity in the Nucleus Accumbens.

Hamilton¹,

Kolb²

2005

Behavioral Neuroscience

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Drugs and other forms of experience (e.g., complex housing) share the ability to alter the dendritic fields of cortical and subcortical neurons. Although such modifications are typically considered advantageous, recent research has demonstrated that psychomotor stimulants (cocaine and amphetamine) block subsequent experience-dependent structural plasticity in the nucleus accumbens (NAcc) and parietal neocortex. The authors investigated whether these findings generalize to another commonly used stimulant (nicotine) and further asked whether prior experience blocks subsequent nicotine-related structural plasticity. Rats were given daily injections of nicotine (or saline) for 14 days either before (Experiment 1) or after (Experiment 2) 2.5-3.0 months of complex (or standard) housing. Nicotine blocked housing-related increases in dendritic branching, length, spine density, and total spines in NAcc; however, complex housing did not block the effects of nicotine. The findings indicate that there are important differences in the capacity of drugs and experience to influence subsequent modifications in dendritic structure.

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Neurobiological mechanisms of nicotine craving

Cited by 29 publications

References 53 publications

Coping strategies for craving management in nicotine dependent patients

Coping strategies for craving management in nicotine dependent patients

Cue-induced reinstatement of nicotine-seeking behavior in rats: effect of bupropion, persistence over repeated tests, and its dependence on training dose

Differential Effects of Nicotine and Complex Housing on Subsequent Experience-Dependent Structural Plasticity in the Nucleus Accumbens.

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