Neurobiological basis of chemotherapy-induced cognitive impairment: A review of rodent research

Seigers, Riejanne; Fardell, Joanna E.

doi:10.1016/j.neubiorev.2010.09.006

Cited by 238 publications

(172 citation statements)

References 145 publications

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“…Dyreforsøk tyder ikke på at noen cytostatikatyper gir mer kognitive problemer enn andre (11). Det er heller ikke påvist sammenheng mellom hvilke ledningsbaner som skades og type cellegift.…”

Section: Andre Forhold Av Betydningunclassified

Er cytostatika skadelig for hjernen?

Østby-Deglum¹,

Dahl²

2013

Tidsskriftet

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Section: Andre Forhold Av Betydningunclassified

Er cytostatika skadelig for hjernen?

Østby-Deglum¹,

Dahl²

2013

Tidsskriftet

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“…En diversos modelos animales se ha detectado una relación consistente entre la administración de quimioterapia y la alteración de algunos dominios cognitivos (9) . Así por ejemplo, El 5FU y el MTX causan en ratones déficits agudos en ciertas funciones cognitivas que requieren la integridad del hipocampo y del lóbulo frontal (3) .…”

Section: Toxicidad Neurológica Inducida Por Los Quimioterápicosunclassified

Bases biológicas del deterioro de la función cognitiva inducido por los tratamientos antineoplásicos

et al. 2012

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Often patients treated with chemotherapy and/or radiotherapy suffer memory and attention problems. The exact mechanisms of action are unknown, although several explanations have been proposed. Both chemotherapy and radiotherapy have a direct toxic effect in the CNS, especially neural progenitor cells and the glia, which are responsible for maintaining neurogenesis in the hippocampus and white matter integrity. Besides the treatments can induce vascular damage in the brain, altering the immune response mediated by cytokines, and hormonal changes secondary to either chemotherapy or hormone therapy itself. The intensity of these effects would be modulated by several genetic factors that influence the ability of neuronal repair, pharmacodynamics and activity of neurotransmitters. Keywords: Cognitive function, cancer, chemotherapy, radiotherapy, chemobrain. ResumenA menudo los pacientes que reciben tratamiento con quimioterapia y/o radioterapia presentan problemas de memoria y de atención. Se desconocen los mecanismos exactos por los que esto se produce, aunque se han propuesto diversas explicaciones. Tanto la quimioterapia como la radioterapia poseen una acción tóxica directa en el SNC, especialmente sobre las células progenitoras neurales y las de la glía, que son las responsables de mantener la neurogénesis del hipocampo y la integridad de la sustancia blanca. A ello cabe añadir el daño que pueden inducir los tratamientos en la vascularización cerebral, la alteración de la respuesta inmune mediada por citoquinas, y los cambios hormonales ya sean secundarios a la quimioterapia o a la propia hormonoterapia. La intensidad de estos efectos estaría modulada por diversos factores genéticos que influyen sobre la capacidad de reparación neuronal, la farmacodinamia y la actividad de los neurotransmisores.

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“…Radiation is well-known to affect different brain structures, including the neural stem cells as well as the glial and vascular (Sundgren andCao, 2009), (Acharya et al, 2010). In addition, majority of the chemotherapeutics used for ALL treatments have numerous effects on the brain, increasing the oxidative stress, reducing neurogenesis, affecting the blood flow and generating white matter damage (Seigers and Fardell, 2011). Previous research has shown that some chemotherapy drugs including cytosine arabinoside as well as radiation (Monje et al, 2002) are toxic at therapeutic doses for the neural stem/progenitor cells (Seigers et al, 2008).…”

Section: Further Directions: Neuroprotective and Restorative Treatmentsmentioning

confidence: 99%

Acute Lymphoblastic Leukemia: What Have We Learned About the Effects of This Disease and Its Treatment on the Nervous System?

Huynh¹,

Sender²,

Bota³

2011

Novel Aspects in Acute Lymphoblastic Leukemia

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Neurobiological basis of chemotherapy-induced cognitive impairment: A review of rodent research

Cited by 238 publications

References 145 publications

Er cytostatika skadelig for hjernen?

Er cytostatika skadelig for hjernen?

Bases biológicas del deterioro de la función cognitiva inducido por los tratamientos antineoplásicos

Acute Lymphoblastic Leukemia: What Have We Learned About the Effects of This Disease and Its Treatment on the Nervous System?

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