Neurobehavioral toxicity of triclosan in mice

Alizadeh-Tabari, Shaghayegh; Esfahani, Mahsa Loran; Hosseini, Seyed Mohammad; Rahimi, Atena

doi:10.1016/j.fct.2019.05.025

Cited by 35 publications

(13 citation statements)

References 33 publications

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“…The effect of the extract (200, 400 and 800 mg/kg, p.o.) on locomotor activity (number of lines crossed in 3 min), anxiety like (time spent in center in seconds) and exploratory behaviors were assessed using the open-field test as previously described [17,18]. The animal was placed in the center of an open field wooden box (40 cm × 40 cm × 40 cm) divided into sixteen equal parts (10 × 10 cm each) with black lines and allowed to freely move for 3 min.…”

Section: Methodsmentioning

confidence: 99%

Salix tetrasperma Roxb. Extract Alleviates Neuropathic Pain in Rats via Modulation of the NF-κB/TNF-α/NOX/iNOS Pathway

et al. 2019

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Patients with neuropathic pain experience chronic painful tingling, burning, and prickling sensations accompanied with hyperalgesia and/or allodynia. In this study, 38 secondary metabolites of a methanol extract from Salix tetrasperma flowers were identified by liquid chromatography-mass spectrometry (HPLC-MS/MS). The extract showed substantial anti-inflammatory, central and peripheral anti-nociceptive, antipyretic, and antioxidant activities in vitro and in different animal models. In the chronic constriction injury (CCI) rat model, the extract was able to attenuate and significantly relieve hyperalgesia and allodynia responses in a dose dependent manner and restore the myelin sheath integrity and Schwann cells average number in the sciatic nerve. The enzyme-linked immunosorbent assay (ELISA) showed that the extract significantly reduced the expression of various pro-inflammatory biomarkers including nuclear factor kabba B (NF-κB), tumor necrosis factor alpha (TNF-α), prostaglandin E2 (PGE2), 5-lipoxygenase (5-LOX), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and the oxidative stress biomarker NADPH oxidase 1 (NOX1), in brain stem and sciatic nerve tissues. These findings were supported by in vitro enzyme inhibition assays (COX-1, COX-2 and 5-LOX). Moreover, the extract significantly reduced p53 expression in the brain stem tissue. These findings support the use of S. tetrasperma in folk medicine to alleviate pain. It could be a promising natural product for further clinical investigations to treat inflammation, nociceptive pain and chronic neuropathic pain.

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Section: Methodsmentioning

confidence: 99%

Salix tetrasperma Roxb. Extract Alleviates Neuropathic Pain in Rats via Modulation of the NF-κB/TNF-α/NOX/iNOS Pathway

et al. 2019

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“…In a previous study, TCS could impair hippocampal synaptic plasticity and lead to memory impairment in male rats [13]. In adult mice, gavage exposure to TCS at a high dose changed locomotor activity and coordination and induced anxiety behavior [14]. Moreover, TCS may adversely affect neural stem cell viability and survival, and TCS may induce neurotoxicity in developing rat brain [15].…”

Section: Introductionmentioning

confidence: 91%

Perinatal Exposure to Triclosan Results in Abnormal Brain Development and Behavior in Mice

Tran¹,

Jung²,

Yoo³

et al. 2020

IJMS

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Triclosan (TCS) is one of the most common endocrine-disrupting chemicals (EDCs) present in household and personal wash products. Recently, concerns have been raised about the association between abnormal behavior in children and exposure to EDC during gestation. We hypothesized that exposure to TCS during gestation could affect brain development. Cortical neurons of mice were exposed in vitro to TCS. In addition, we examined in vivo whether maternal TCS administration can affect neurobehavioral development in the offspring generation. We determined that TCS can impair dendrite and axon growth by reducing average length and numbers of axons and dendrites. Additionally, TCS inhibited the proliferation of and promoted apoptosis in neuronal progenitor cells. Detailed behavioral analyses showed impaired acquisition of spatial learning and reference memory in offspring derived from dams exposed to TCS. The TCS-treated groups also showed cognition dysfunction and impairments in sociability and social novelty preference. Furthermore, TCS-treated groups exhibited increased anxiety-like behavior, but there was no significant change in depression-like behaviors. In addition, TCS-treated groups exhibited deficits in nesting behavior. Taken together, our results indicate that perinatal exposure to TCS induces neurodevelopment disorder, resulting in abnormal social behaviors, cognitive impairment, and deficits in spatial learning and memory in offspring.

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“…Some of the toxicity mechanisms of TCS were confirmed in the in vivo studies on rodents (Table 3 ). Multiple neurodegenerative TCS effects were determined in mice and rats, including reduced spatial memory performance, anxiety-related behavior and reduced neuromuscular functions (Arias-Cavieres et al 2018 ; Tabari et al 2019 ). Neurobehavioral toxicity was also observed in the mice offspring after subcutaneous treatment with TCS (Tran et al 2020 ).…”

Section: Possible Adverse Effects Of Tcsmentioning

confidence: 99%

Comprehensive insight into triclosan—from widespread occurrence to health outcomes

Milanović

Đurić

Milošević

et al. 2021

Environ Sci Pollut Res

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Neurobehavioral toxicity of triclosan in mice

Cited by 35 publications

References 33 publications

Salix tetrasperma Roxb. Extract Alleviates Neuropathic Pain in Rats via Modulation of the NF-κB/TNF-α/NOX/iNOS Pathway

Salix tetrasperma Roxb. Extract Alleviates Neuropathic Pain in Rats via Modulation of the NF-κB/TNF-α/NOX/iNOS Pathway

Perinatal Exposure to Triclosan Results in Abnormal Brain Development and Behavior in Mice

Comprehensive insight into triclosan—from widespread occurrence to health outcomes

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