Perinatal Exposure to Triclosan Results in Abnormal Brain Development and Behavior in Mice

Abstract

Triclosan (TCS) is one of the most common endocrine-disrupting chemicals (EDCs) present in household and personal wash products. Recently, concerns have been raised about the association between abnormal behavior in children and exposure to EDC during gestation. We hypothesized that exposure to TCS during gestation could affect brain development. Cortical neurons of mice were exposed in vitro to TCS. In addition, we examined in vivo whether maternal TCS administration can affect neurobehavioral development in the offspring generation. We determined that TCS can impair dendrite and axon growth by reducing average length and numbers of axons and dendrites. Additionally, TCS inhibited the proliferation of and promoted apoptosis in neuronal progenitor cells. Detailed behavioral analyses showed impaired acquisition of spatial learning and reference memory in offspring derived from dams exposed to TCS. The TCS-treated groups also showed cognition dysfunction and impairments in sociability and social novelty preference. Furthermore, TCS-treated groups exhibited increased anxiety-like behavior, but there was no significant change in depression-like behaviors. In addition, TCS-treated groups exhibited deficits in nesting behavior. Taken together, our results indicate that perinatal exposure to TCS induces neurodevelopment disorder, resulting in abnormal social behaviors, cognitive impairment, and deficits in spatial learning and memory in offspring.

4-tert-Octylphenol Exposure Disrupts Brain Development and Subsequent Motor, Cognition, Social, and Behavioral Functions

“…Moreover, rat administered butylparaben during the period from early pregnancy to weaning produce offspring with autism-like symptoms [ 22 ]. Perinatal exposure to triclosan induced neurodevelopment disorder and led to abnormal social behaviors, cognitive impairment, and deficits in spatial learning and memory [ 10 ]. These observations suggest that OP may also impair central nervous system development.…”

“…For experimental design, offspring mice between 6- and 10-week age were randomly selected to perform behavior tests [ 10 , 13 ].…”

“…In humans, the EDC exposure in women has been associated with early neurodevelopmental performance in their offspring at the age of 1–2 years [ 9 ]. In mice, prenatal exposure to triclosan impaired brain development and resulting in abnormal behavior [ 10 ]. These results suggest that early exposure to EDCs can result in neurodevelopmental disorders and lead to abnormal behavior.…”

A Review on the Fate of Legacy and Alternative Antimicrobials and Their Metabolites during Wastewater and Sludge Treatment

“…Kim et al [150] and Park et al [151] both showed that perinatal TCS exposure caused porcine mitochondrial disruption and oxidative stress. Tran et al [152] demonstrated that perinatal TCS exposure induced neurodevelopment disorders in mice, leading to significant social, cognitive and learning defects in offspring mice.…”

Antimicrobial Agent Triclosan Inhibits Acetylcholinesterase Activityin Vitroin a Dose-Dependent Manner

“…Briefly, it is reported that triclosan affects immune responses, cardiovascular functions, and ROS production [1]. Studies carried out in mice indicate that prenatal exposure to triclosan can induce neurodevelopmental disorders [4]. Recently, we showed that triclosan has the potential to induce neurotoxicity at sublethal concentrations by inhibiting acetylcholinesterase (AChE) enzyme in vivo [5].…”