Neurobehavioral, physiological and inflammatory impairments in response to bifenthrin intoxication in Oreochromis niloticus fish: Role of dietary supplementation with Petroselinum crispum essential oil

Farag, Mayada R.; Mahmoud, Hemat K.; Elsayed, Shereen; Ahmed, Sarah Y.A.; Alagawany, Mahmoud; Abou‐Zeid, Shimaa M.

doi:10.1016/j.aquatox.2020.105715

Cited by 33 publications

(16 citation statements)

References 42 publications

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“…The DNA oxidation by xenobiotics may help the initiation of proapoptotic-encoding pathways resulting in cellular death, as the apoptosis process is mostly regulated by the cysteine proteases expressions, including caspases family members (the apoptotic pathways promoters) and the anti-apoptotic protein Bcl-2 [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…This was indicated by the obtained upregulation of TNF-α, IL-1β, and IFN-γ mRNA expression. The proinflammatory cytokines induction is a primary indicator of the inflammatory process [ 1 ]. NF-κB has a strategic position at the crossroad between inflammation and oxidative stress; it is suggested that ROS might act as a key secondary mediator responsible for the activation of NF-κB in response to various stimuli [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

“…Insecticides are widely employed in agriculture to control pests and enhance crop productivity. However, the extensive and uncontrolled use of these insecticides can potentially affect the ecological environment, and almost all of them represent a threat to non-target organisms including humans [ 1 ]. In the last two decades, the use of neonicotinoids (neonics) spread worldwide, becoming the most important pesticide class currently present in [ 2 ] the global market as replacers of carbamates and organophosphates [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Thiacloprid Induced Developmental Neurotoxicity via ROS-Oxidative Injury and Inflammation in Chicken Embryo: The Possible Attenuating Role of Chicoric and Rosmarinic Acids

Farag

Khalil

Zaglool

et al. 2021

Biology

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Insecticides are widely employed in agriculture to control pests and as major factors for enhancing crop productivity. Thiacloprid (TH) is one of the most-used insecticides worldwide. In this study, the negative impact of TH on the brain tissue of developing chicken embryo models and the modulatory effect of chicoric (CA) and rosmarinic (RA) acids were investigated. The eggs were injected in ovo with different doses of TH (0.1, 1, 10, and 100 μg/egg). TH significantly increased the oxidative damage in the brain of exposed embryos in a dose-dependent manner (p < 0.05). TH significantly elevated the oxidative stress markers; protein carbonyl, malondialdehyde content, and DNA damage (p < 0.05). Myeloperoxidase activity and nitric oxide significantly increased with overexpression of the pro-inflammatory cytokines (interferon gamma, tumor necrosis factor alpha, and interleukin-1 beta) and stress-related and apoptotic genes (NF-KB, Caspase-3) in the brain tissue on both biochemical and molecular levels (p < 0.05), while downregulating the expression of antiapoptotic Bcl-2. Co-treatment of CA and RA with TH markedly decreased the insecticide-induced toxicity with a prominent synergistic effect (p < 0.05). In conclusion, TH is suggested to be a possible neurotoxic to embryos of vertebrates including human. The study also revealed the antioxidant, anti-inflammatory, genoprotective, and antiapoptotic property of CA and RA against TH toxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thiacloprid Induced Developmental Neurotoxicity via ROS-Oxidative Injury and Inflammation in Chicken Embryo: The Possible Attenuating Role of Chicoric and Rosmarinic Acids

Farag

Khalil

Zaglool

et al. 2021

Biology

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“…Neonicotinoids (neonics) are synthetic insecticides that have been extensively utilized for pest management and crop protection in domestic, agricultural, and veterinary practices since their introduction in the 1990s [ 1 , 2 , 3 ]. Neonics irreversibly bind to nicotinic acetylcholine receptors of target insects disrupting the transduction of neuron cholinergic signals and causing behavior abnormalities, immobility, and finally death of the insect [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Neonicotinoid Thiacloprid Interferes with the Development, Brain Antioxidants, and Neurochemistry of Chicken Embryos and Alters the Hatchling Behavior: Modulatory Potential of Phytochemicals

Farag

Alagawany

Moselhy

et al. 2022

Biology

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The present experiment was performed to investigate the toxic impact of thiacloprid (TH) on the brain of developing chicken embryos and also to measure its influence on the behavioral responses of hatchlings. The role of chicoric acid (CA) and rosmarinic acid (RA) in modulating the resulted effects was also investigated. The chicken eggs were in ovo inoculated with TH at different doses (0.1, 1, 10, and 100 ug/egg). TH increased the mortality and abnormality rates and altered the neurochemical parameters of exposed embryos dose-dependently. TH also decreased the brain level of monoamines and amino acid neurotransmitters and decreased the activities of acetylcholine esterase (AchE) and Na+/K+-ATPase. The brain activity of catalase (CAT) and superoxide dismutase (SOD) was diminished with downregulation of their mRNA expressions in the brain tissue. When TH was co-administered with CA and RA, the toxic impacts of the insecticide were markedly attenuated, and they showed a complementary effect when used in combination. Taken together, these findings suggested that TH is neurotoxic to chicken embryos and is possibly neurotoxic to embryos of other vertebrates. The findings also demonstrated the antioxidant and neuroprotective effects of CA and RA. Based on the present findings, the CA and RA can be used as invaluable ameliorative of TH-induced toxicity.

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“…Research in the eld of toxicology has always focused on offering natural plant oils to alleviate various toxic insults (Abou-Zeid et al 2018). These oils contain phytochemicals with little harm and strong antioxidant activity making them valuable drugs (Farag et al 2021). Among them, sesame (Sesamum indicum) oil which contains sesamol (SML), a natural phenolic lignan with the chemical structure 3,4-(Methylenedioxy) phenol (Majdalawieh and Mansour 2019).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Sesamol Against Aluminum Nanoparticles induced Toxicity in Rats

Abou‐Zeid

Elkhadrawey

Anis

et al. 2021

Preprint

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Alumina nanoparticles (AlNPs) are widely used causing neurobehavioral impairment in intoxicated animals and human. Sesamol (SML) emerged as a natural phytochemical with potent antioxidant and anti-inflammatory properties. However, no study has directly tested the potential of SML to protect against AlNPs induced detrimental effects on the brain. AlNPs (100 mg/kg) were orally administered to `rats by gavage with or without oral sesamol (100 mg/kg) for 28 days. In AlNPs-intoxicated group, brain AChE activity was elevated. The concentrations of MDA and 8-OHdG were increased suggesting lipid peroxidation and oxidative DNA damage. GSH depletion with inhibited activities of CAT and SOD were demonstrated. Serum levels of IL-1β and IL-6 were elevated. The expressions of GST, TNF-α and caspase-3 genes in brain were upregulated. Histopathologically, AlNPs induced hemorrhages, edema, neuronal necrosis and/ or apoptosis in medulla oblongata. The cerebellum showed loss of Purkinje cells and the cerebrum showed perivascular edema, neuronal degeneration, necrosis, and neuronal apoptosis. However, concomitant administration of SML with AlNPs significantly ameliorated the toxic effects on the brain, reflecting antioxidant, anti-inflammatory and anti-apoptotic effects of SML. Considering these results, sesamol could be promising phytochemical with neuroprotective activity against AlNPs-induced neurotoxicity.

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Neurobehavioral, physiological and inflammatory impairments in response to bifenthrin intoxication in Oreochromis niloticus fish: Role of dietary supplementation with Petroselinum crispum essential oil

Cited by 33 publications

References 42 publications

Thiacloprid Induced Developmental Neurotoxicity via ROS-Oxidative Injury and Inflammation in Chicken Embryo: The Possible Attenuating Role of Chicoric and Rosmarinic Acids

Thiacloprid Induced Developmental Neurotoxicity via ROS-Oxidative Injury and Inflammation in Chicken Embryo: The Possible Attenuating Role of Chicoric and Rosmarinic Acids

The Neonicotinoid Thiacloprid Interferes with the Development, Brain Antioxidants, and Neurochemistry of Chicken Embryos and Alters the Hatchling Behavior: Modulatory Potential of Phytochemicals

Neuroprotective Effect of Sesamol Against Aluminum Nanoparticles induced Toxicity in Rats

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