Neurobehavioral effects of lithium in the rat: Investigation of the effect/concentration relationships and the contribution of the poisoning pattern

Hanak, Anne-Sophie; Chevillard, L; Lebeau, Rodolphe; Risède, Patricia; Laplanche, Jean‐Louis; Benturquia, Nadia; Mégarbane, Bruno

doi:10.1016/j.pnpbp.2017.03.005

Cited by 11 publications

(9 citation statements)

References 56 publications

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“…The sequence of arm entries was recorded over a 10-min period. The number of spontaneous alternations was determined as previously described (Hanak et al, 2017). The proportion of alternations was calculated by dividing the number of alternations by the total number of arm visits.…”

Section: Methodsmentioning

confidence: 99%

“…Anxiety-like behavior. The anxiety-like behavior was measured in the elevated plus-maze (EPM) test (Hanak et al, 2017). The maze, placed 50 cm above an infrared floor, consisted of black Plexiglas boards forming a central platform (10 cm × 10 cm) surrounded by two opposed highly illuminated (180 lux) open arms (50 cm × 10 cm) and two opposed faintly illuminated (10 lux) enclosed arms (50 cm × 10 cm with 45 cm-high walls).…”

Section: Behavioral Measurementsmentioning

confidence: 99%

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Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat

et al. 2019

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Background: The substantial increase in use of 3,4-methylenedioxypyrovalerone (MDPV), a popular recreational synthetic cathinone, has raised legitimate questions about its behavioral consequences and abuse liability. Aims: The aim of this study was to study MDPV-induced neurobehavioral effects in the rat, using different paradigms traditionally developed to study drug-attributed addictive properties. Methods: Different patterns of intraperitoneal 3 mg/kg MDPV administration were investigated. Consequences on rat horizontal locomotion and behavior of acute, intermittent (once daily dosing over 10 days), and binge (three-time daily dosing for 3 days) MDPV administration as well as challenge after 10 day MDPV withdrawal were studied. The dopamine receptor-D1 antagonist, SCH23390, was bilaterally infused in the nucleus accumbens to determine the role of D1-receptors in MDPV-related effects on the associative memory recall using the conditioned place preference paradigm. In addition, in a separate experience using western blot, we investigated the effects of chronic MDPV administration (four injections during 24 h) on ΔFosB expression in the nucleus accumbens, caudate putamen, and prefrontal cortex. Results: Acute MDPV administration increased stereotypies and open arm entries in the elevated plus maze while SCH23390 abolished MDPV-induced enhancing effects on memory consolidation. Intermittent MDPV administration resulted in sensitization of MDPV-induced locomotor effects and tolerance during the following challenge. With binge MDPV administration, locomotor activity was not altered despite tolerance onset after challenge. SCH23390 abolished MDPV-induced conditioned place preference. Chronic MDPV administration induced ΔFosB accumulation in the nucleus accumbens, caudate putamen, and prefrontal cortex. Conclusions: Our findings clearly show that MDPV produces profound behavioral alterations mediated by the activation of the dopaminergic system similarly to other amphetamines.

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Section: Methodsmentioning

confidence: 99%

Section: Behavioral Measurementsmentioning

confidence: 99%

Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat

et al. 2019

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“…The exact mechanisms involved in lithium‐induced neurotoxicity remain unknown. Recent rat studies mimicking acute and acute‐on‐chronic lithium poisoning have shown that lithium‐induced neurotoxicity was associated with lithium accumulation in the brain followed by slower and delayed elimination in comparison to the blood . If pharmacokinetic studies have demonstrated the effectiveness of ECTR in removing lithium from the blood, there is no evidence that ECTR could enhance lithium elimination from the brain .…”

Section: Discussionmentioning

confidence: 99%

“…Recent rat studies mimicking acute and acute-on-chronic lithium poisoning have shown that lithium-induced neurotoxicity was associated with lithium accumulation in the brain followed by slower and delayed elimination in comparison to the blood. [14][15][16] If pharmacokinetic studies have demonstrated the effectiveness of ECTR in removing lithium from the blood, 17,18 there is no evidence that ECTR could enhance lithium elimination from the brain. 1,3 In accordance, no difference in outcome was reported between lithium-poisoned patients for whom haemodialysis was carried out and those for whom it was recommended by the poison control centre but not done, suggesting that indications for haemodialysis in lithium poisoning should be reconsidered to include only the more severe cases.…”

Section: Potential Impact Of Extrip Vs Paris Criteria On the Outcommentioning

confidence: 99%

Assessment of Extracorporeal Treatments in Poisoning criteria for the decision of extracorporeal toxin removal in lithium poisoning

Vodovar

Beaune

Langrand

et al. 2019

Brit J Clinical Pharma

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Aims To assess recommendations provided by the EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup on extracorporeal toxin removal (ECTR) in lithium poisoning. Methods Retrospective assessment in a 128 lithium‐poisoned patient cohort previously used to identify ECTR initiation criteria that could improve outcome (Paris criteria). ECTR requirement using EXTRIP criteria was compared to the actual practice or if Paris criteria were used. The potential impact on outcome if these different criteria were used was investigated. Results Using the recommended (Rec‐EXTRIP) or recommended + suggested (All‐EXTRIP) EXTRIP criteria, ECTR would have been indicated in more patients than was actually done (P < .001), or if Paris criteria were used (P < .01). The non‐actually ECTR‐treated patients fulfilling Rec‐EXTRIP or All‐EXTRIP criteria had shorter intensive care unit stay (P < .05) and no significant increase in fatalities and neurological impairment on discharge in comparison to the actually ECTR‐treated patients. ECTR requirements using EXTRIP vs Paris criteria were not concordant (P < .001). In the non‐actually ECTR‐treated patients, 31/106 and 55/106 patients fulfilled Rec‐EXTRIP or All‐EXTRIP but not Paris criteria, respectively. Those patients had longer stay (P < .01) but no worse neurological impairment on discharge than the patients not fulfilling any of these criteria (50/106 and 26/106, respectively). In the non‐actually ECTR‐treated patients, 7/106 fulfilled Paris but not Rec‐EXTRIP criteria. Those patients had longer stay (P < .05) and worse neurological impairment on discharge (P < .01) than the 50/106 patients not fulfilling any of these criteria. Conclusion In this cohort of lithium poisonings, EXTRIP criteria may lead to more ECTR than actually performed or if the Paris criteria were used, with no demonstrated improvement in outcome.

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“… [ 104 ] Rat (Sprague-Dawley) 800 Li 1 Locomotion ↓, rearing ↓, anxiety ↑, impaired memory, and brain acute chronic poisoning. [ 105 ] Rat (Wistar) 1 mM kg −1 day −1 [ 106 , 107 ] 28 Oxidative-nitrosative stress ↑, stimulated nuclear translocation of nuclear factor erythroid-2-related factor 2, phosphoinositide 3-kinase activity ↓, protection against ventricular arrhythmias, HSP70 ↓. [ 106 , 107 ] [ 106 , 107 ] 28 Rat (albino) 100 mg kg −1 day −1 Li 2 CO 3 28 MDA, creatinine, and neuron-specific enolase ↑; testosterone, superoxide dismutase, and glutathione ↓; massive loss of sperm atonic cells.…”

Section: Impact Of LI On Animalsmentioning

confidence: 99%

Reimagining safe lithium applications in the living environment and its impacts on human, animal, and plant system

Shakoor¹,

Adeel²,

Zain³

et al. 2023

Environmental Science and Ecotechnology

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Neurobehavioral effects of lithium in the rat: Investigation of the effect/concentration relationships and the contribution of the poisoning pattern

Cited by 11 publications

References 56 publications

Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat

Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat

Assessment of Extracorporeal Treatments in Poisoning criteria for the decision of extracorporeal toxin removal in lithium poisoning

Reimagining safe lithium applications in the living environment and its impacts on human, animal, and plant system

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