Neuroanatomical distribution of androgen and estrogen receptor-immunoreactive cells in the brain of the male roughskin newt

Davis, Glen A.; Moore, Frank L.

doi:10.1002/(sici)1096-9861(19960819)372:2<294::aid-cne10>3.0.co;2-k

Cited by 46 publications

(16 citation statements)

References 75 publications

(120 reference statements)

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“…The expression pattern of AR‐ir and mRNA in green anoles is remarkably similar to that detected by various techniques in diverse vertebrate groups, ranging from fish to mammals. In particular, localization of AR to regions of the POA and hypothalamus, as well as other limbic structures (28, 37–41), is consistent with the highly conserved function of these regions in facilitating reproductive and aggressive behaviours (42–45). The presence of AR in midbrain auditory nuclei (e.g.…”

Section: Discussionsupporting

confidence: 61%

“…The presence of AR in midbrain auditory nuclei (e.g. torus semicircularis) also appears to be evolutionarily conserved, as similar labelling has been detected in the oyster toadfish (46), roughskin newt (38), African clawed frog (47), and garter snake (39). In addition to the anole, AR has been detected in the hypoglossal nucleus of the rat via in situ hybridization (41) and immunohistochemistry (48) and in various avian species via autoradiography (49–51), immunohistochemistry (33), and in situ hybridization (52).…”

Section: Discussionmentioning

confidence: 65%

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Distribution of Androgen Receptor mRNA Expression and Immunoreactivity in the Brain of the Green Anole Lizard

Rosen

O'Bryant

Matthews

et al. 2002

J Neuroendocrinology

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Male courtship and copulation are androgen dependent in the green anole lizard, and female receptivity can be facilitated by testosterone. However, only a few, and relatively large, regions in the brain have been implicated in the control of these behaviours. In situ hybridization and immunohistochemistry were therefore used to determine in detail where androgens are likely to act in the brains of breeding males and females. A 697-bp fragment of the anole androgen receptor (AR) was cloned from total RNA isolated from the kidney, which contains the highly androgen-sensitive renal sex segment. The cloned fragment spanned part of the C, the entire D, and part of the E domains, and shared a high degree of similarity with the AR of various species. 35S-labelled antisense and sense probes were generated from the 697-bp fragment for use in in situ hybridization, and the AR antibody PG-21 was used for immunohistochemistry. Both sexes consistently had AR mRNA expression and immunoreactivity in areas associated with vertebrate reproductive behaviours and in motor areas of the brainstem. Interestingly, the PG-21 antibody produced labelling in both the nucleus and cytoplasm, including neuronal processes. The distribution of mRNA and immunoreactivity were comparable in males and females, and the amount of labelling was generally similar, although slightly greater in females. The expression pattern of AR in this species supports the idea that distribution is highly conserved among vertebrates, but that it probably does not dictate behavioural differences between the sexes in anoles.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 65%

Distribution of Androgen Receptor mRNA Expression and Immunoreactivity in the Brain of the Green Anole Lizard

Rosen

O'Bryant

Matthews

et al. 2002

J Neuroendocrinology

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“…Lesions of the entire septal region in female gray tree frogs lead to a deficit in phonotaxis response (Walkowiak et al, 1999). However, steroid hormone receptors have been indentified in this region in frogs and newts (Davis and Moore, 1998;Chakraborty and Burmeister, 2010;O'Connell et al, 2011a), suggesting that sex steroid hormones could potentially modulate behavior through action in this nucleus.…”

Section: Amphibiansmentioning

confidence: 99%

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

O’Connell

Hofmann

2011

J of Comparative Neurology

849

879

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All animals evaluate the salience of external stimuli and integrate them with internal physiological information into adaptive behavior. Natural and sexual selection impinge on these processes, yet our understanding of behavioral decision-making mechanisms and their evolution is still very limited. Insights from mammals indicate that two neural circuits are of crucial importance in this context: the social behavior network and the mesolimbic reward system. Here we review evidence from neurochemical, tract-tracing, developmental, and functional lesion/stimulation studies that delineates homology relationships for most of the nodes of these two circuits across the five major vertebrate lineages: mammals, birds, reptiles, amphibians, and teleost fish. We provide for the first time a comprehensive comparative analysis of the two neural circuits and conclude that they were already present in early vertebrates. We also propose that these circuits form a larger social decision-making (SDM) network that regulates adaptive behavior. Our synthesis thus provides an important foundation for understanding the evolution of the neural mechanisms underlying reward processing and behavioral regulation. J. Comp. Neurol. 519:3599-3639, 2011. INDEXING TERMS: social behavior; comparative neuroanatomy; amphibian; reptile; bird; teleost; reward system; social behavior network; limbic system; neural circuitsThroughout their lives, all animals constantly face situations that provide either challenges (e.g., aggression, predation) or opportunities (e.g., reproduction, foraging, habitat selection) (for a detailed review, see O'Connell and Hofmann, 2011). In all cases, environmental cues are processed by sensory systems into a meaningful biological signal while internal physiological cues (e.g., condition, maturity) and prior experience are integrated at the same time. This process usually results in behavioral actions that are adaptive, i.e., beneficial to the animal. To accomplish this, an animal's nervous system must evaluate the salience of a stimulus and elicit a context-appropriate behavioral response. Despite tremendous progress in understanding the ecology and evolution of social behavior (Lorenz, 1952;Tinbergen, 1963;Lehrman, 1965;von Frisch, 1967;Krebs and Davies, 1993;Stephens, 2008), it is less understood where in the brain these decisions (e.g., about mate choice or territory defense) are made and how these brain circuits have arisen over the course of vertebrate evolution.Recent research has begun to decipher the neural basis of social decision-making. In mammals in particular, the neural circuits that evaluate stimulus salience and/or regulate social behavior have been uncovered to some degree: the mesolimbic reward system and social behavior network (Fig. 1). It is becoming increasingly clear that the reward system (including but not limited to the midbrain dopaminergic system) is the neural circuit where the salience of an external stimulus is evaluated (Deco and Rolls, 2005;Wickens et al., 2007), as appetitive beh...

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“…Details for the anuran model are based on Emerson and Boyd (1999). Anatomical information for the urodele model is based on Thompson and Moore (2000), steroid hormone receptor information is based on Davis and Moore (1996), and AVT receptor distribution is based on Boyd and Moore (1991). Abbreviations: AR, androgen receptor; AVT-R, arginine vasotocin receptor; ER, estrogen receptor; n. IX-X, motor nucleus of cranial nerve IX-X; POA, preoptic area; PTN, pretrigeminal nucleus; TS, torus semicircularis.…”

Section: Behavioral Endocrinology and Behavioral Ecologymentioning

confidence: 99%

Current research in amphibians: Studies integrating endocrinology, behavior, and neurobiology

Wilczynski

Lynch

O'Bryant

2005

Hormones and Behavior

107

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Amphibian behavioral endocrinology has focused on reproductive social behavior and communication in frogs and newts. Androgens and estrogens are critical for the expression of male and female behavior, respectively, and their effects are relatively clear. Corticosteroids have significant modulatory effects on the behavior of both sexes, as does the peptide neuromodulator arginine vasotocin in males, but their effects and interactions with gonadal steroids are often complex and difficult to understand. Recent work has shown that the gonadal hormones and social behavior are mutually reinforcing: engaging in social interactions increases hormone levels just as increasing hormone levels change behavior. The reciprocal interactions of hormones and behavior, as well as the complex interactions among gonadal steroids, adrenal steroids, and peptide hormones have implications for the maintenance and evolution of natural social behavior, and suggest that a deeper understanding of both endocrine mechanisms and social behavior would arise from field studies or other approaches that combine behavioral endocrinology with behavioral ecology.

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Neuroanatomical distribution of androgen and estrogen receptor-immunoreactive cells in the brain of the male roughskin newt

Cited by 46 publications

References 75 publications

Distribution of Androgen Receptor mRNA Expression and Immunoreactivity in the Brain of the Green Anole Lizard

Distribution of Androgen Receptor mRNA Expression and Immunoreactivity in the Brain of the Green Anole Lizard

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

Current research in amphibians: Studies integrating endocrinology, behavior, and neurobiology

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