Neuroanatomic Correlates of Psychopathologic Components of Major Depressive Disorder

Milak, Matthew S.; Parsey, Ramin V.; Keilp, John G.; Oquendo, María A.; Malone, Kevin; Mann, J. John

doi:10.1001/archpsyc.62.4.397

Cited by 156 publications

(117 citation statements)

References 192 publications

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“…Less obvious, subjective aspects of depression, however, may be related to these impairments. Psychological aspects of depression are related to elevated glucose metabolism in dorsal cingulate (Milak et al, 2005), a region commonly activated by Stroop tasks (Posner & DiGirolomo, 1998;Cohen et al, 2004;Wagner et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Attention deficit in depressed suicide attempters

Keilp

Gorlyn

Oquendo

et al. 2008

Psychiatry Research

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184

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Attention is typically impaired in depression and may play a role in risk for suicidal behavior. In this study, 66 non-patients, 83 depressed subjects with no past history of suicide attempt, 53 depressed subjects with one or more low lethality suicide attempts, and 42 depressed subjects with at least one high lethality attempt were compared on two computerized measures of attention, a Continuous Performance Test (CPT) and a Stroop task. All subjects were medication free at the time of assessment. Attention was impaired in all depressed subjects but worse in those with a past history of suicidal behavior. CPT performance did not differ among the groups, but Stroop interference was significantly poorer in all depressed subjects relative to non-patients, and poorer still in high lethality suicide attempters relative to all other groups. Interference score correlated modestly with subjective depression, functional level, suicide ideation, number of past suicide attempts, and lethality of past attempts. Depression-related impairments of attention, especially susceptibility to interference, are accentuated in those with a past history of suicidal behavior. Fundamental deficits in attention control may play a role in risk for suicidal behavior, and may contribute to a variety of cognitive deficits in suicidal patients. Brain mechanisms subserving attention control, which overlap considerably with regions implicated in affective disorders, may be a useful target for studies seeking to characterize neuropsychological factors associated with suicidal behavior.

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Section: Discussionmentioning

confidence: 99%

Attention deficit in depressed suicide attempters

Keilp

Gorlyn

Oquendo

et al. 2008

Psychiatry Research

Self Cite

184

121

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show abstract

“…In depressed patients, response to antidepressant treatment has been associated with changes in blood flow and metabolic activity in the cerebellum (Holthoff et al 2004;Mayberg et al 2000). Recently, metabolic activity in the basal ganglia and cerebellum has been associated with the severity of insomnia complaints assessed on the Hamilton Rating Scale for Depression (Milak et al 2005). Increased metabolic activity in the basal ganglia and the cerebellum during evening wakefulness may also contribute to stimulate and maintain increased frontal metabolism concomitant with mood improvements.…”

Section: Discussionmentioning

confidence: 99%

Diurnal Variation in Regional Brain Glucose Metabolism in Depression

Germain

Nofzinger

Meltzer

et al. 2007

Biological Psychiatry

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“…These brain regions include the prefrontal cortex, anterior cingulate, amygdala, hippocampus and thalamus, structures involved in regulating mood, memory and behavior and manifesting altered activity in major depression. 1 Alterations in serotonergic function are implicated in the pathogenesis of major depression and in the diathesis for suicidal behavior. 2,3 Since genetic factors can contribute causally to both major depression and the proclivity to commit suicide 4,5 and since the serotonergic system is partially regulated by genetic factors, 6,7 candidate genes for both major depression and suicidal behavior could involve the serotonergic system.…”

Section: Introductionmentioning

confidence: 99%

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression

et al. 2008

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Impaired brain serotonin neurotransmission is a potential component of the diathesis of major depression. Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and a cause of impaired serotonin transmission. Here, we identify a novel TPH2 short isoform with truncated catalytic domain expressed in human brainstem, prefrontal cortex, hippocampus and amygdala. An exploratory study of 166 Caucasian subjects revealed association with major depression or suicide of a novel single nucleotide polymorphism (SNP) g.22879A > G located in exon 6 of this short isoform. This SNP and additional SNPs were discovered through a systematic characterization of the genetic architecture of the TPH2 gene for further genetic and functional investigations of its relationship to major depression and other psychopathology.

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Neuroanatomic Correlates of Psychopathologic Components of Major Depressive Disorder

Cited by 156 publications

References 192 publications

Attention deficit in depressed suicide attempters

Attention deficit in depressed suicide attempters

Diurnal Variation in Regional Brain Glucose Metabolism in Depression

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression

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