Diurnal Variation in Regional Brain Glucose Metabolism in Depression

Germain, Anne; Nofzinger, Eric A.; Meltzer, Carolyn C.; Wood, Annette; Kupfer, David J.; Moore, Robert Y.; Buysse, Daniel J.

doi:10.1016/j.biopsych.2006.09.043

Cited by 53 publications

(34 citation statements)

References 43 publications

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“…The hypothalamo-pituitary-adrenocortical (HPA) axis response is initiated on a slightly longer time scale (due to its neuroendocrine components). The HPA axis introduces glucocorticoid hormones into the circulation to provide further redistribution of energy resources (e.g., hepatic gluconeogenesis), while also serving to limit the duration and impact of the initial stress response [13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The findings are consistent with the results of our study, that blood pressure and heart rate increases progressively in stress conditions in both study groups [13].…”

Section: Discussionsupporting

confidence: 90%

“…The findings are consistent with the results of our study, that blood pressure and heart rate increases progressively in stress conditions in both study groups [13]. Since it is evident that HPA axis response which causes cortisol release and sequalae of increased blood glucose level is a delayed response and initial sympathetic nervous system response causes release of norepinephrine causes peripheral uptake of glucose and thus resultant temporary lowering of glucose levels in groups I and II and group II exhibits no decline because of additional supplementation of glucose [19][20][21][22][23][24][25].…”

Section: Discussionsupporting

confidence: 89%

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Using Blood Glucose Estimation to Interpret Stress in Patients Undergoing Minor Oral Surgery Procedures

Murugan

kulsum

Neelak

et al. 2017

JDHODT

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Purpose: A prospective randomised case control study was conducted to evaluate the stress induced in patients during minor oral surgical procedures based on the variations in blood glucose levels, blood pressure and pulse rate and thereby to assess the relation between stress and the aforesaid parameters. Materials and methods:A total of 100 subjects who required routine minor oral surgical procedures were randomly divided into two equal groups with subjects of test Group I receiving 2 % lignocaine with adrenaline, subjects of control Group II received the same with an added oral intake of 10 mg glucose in 200 ml water after administration of local anaesthesia. The blood glucose level, blood pressure, and pulse rate were recorded before the commencement of procedure with the patient on the chair, before and immediately after local anaesthetic administration, finally after the procedure, and the obtained data was statistically analysed. Results:The blood glucose levels were found to decline at a point before extraction and then increase to a value higher than the preoperative value in group I, while in groups II the blood sugar values maintain a steady state without decline, until it progressively increases to a higher post-operative value. In all groups blood pressure was found to elevate progressively and an increase in pulse rate was observed in all stages till the administration of LA after which there was a marked decline. Conclusion:Our results point towards the phenomenon of a short lasting decline in blood glucose levels for a period of not more than four or five minutes before an elevation in blood glucose levels. In minor oral surgical procedures under local anaesthesia, this momentary hypoglycaemia is of great clinical significance as even moderate hypoglycaemia can lead to episodes of psychogenic syncope.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Using Blood Glucose Estimation to Interpret Stress in Patients Undergoing Minor Oral Surgery Procedures

Murugan

kulsum

Neelak

et al. 2017

JDHODT

View full text Add to dashboard Cite

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“…This pattern may reflect an input from the circadian timing system to promote wakefulness in face of the increasing sleep pressure. Considering that circadian rhythms can be attenuated in depression, diurnal variations in rCMRglc in brainstem and hypothalamic areas may be, therefore, blunted in depressed compared to healthy individuals [55].…”

Section: Depression and Circadian Rhythmsmentioning

confidence: 99%

Chronobiology, excessive daytime sleepiness and depression: Is there a link?

2009

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The complaint of excessive daytime sleepiness (EDS), commonly encountered in clinical practice, may arise from a variety of psychiatric disorders, most importantly depression. Even though EDS frequently leads depressed patients to seek medical assistance, it is commonly under-evaluated and under-diagnosed. Therefore, a comprehensive understanding and management of EDS is essential in the clinical assessment of depression. Within a theoretical framework, a chronobiological approach may shed new light on the complex interaction of EDS and depression. In this review, studies on EDS and depression are summarized and discussed within the context of circadian and sleep regulatory mechanisms. Furthermore, potential chronobiological therapeutic strategies are proposed to address some of the unmet needs in the treatment of EDS and depression.

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“…Despite evidence of shared risk and overlapping pathophysiology, there is only a limited understanding of the specific biological mechanisms predisposing patients to comorbidity of psychiatric and metabolic disorders. Factors such as regulation of reward, chronic stress, and energy utilization have been proposed [24,25], but the causal interactions among these variables remain poorly understood [13].…”

Section: Metabolic Comorbidity In Psychiatric Disordersmentioning

confidence: 99%

Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders

Barandas

Landgraf

McCarthy

et al. 2015

Curr Psychiatry Rep

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Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regulate affective, cognitive, and metabolic functions, and neuropsychiatric and metabolic diseases are often correlated with disturbances of circadian rhythms, we hypothesize that dysregulation of circadian clocks plays a central role in metabolic comorbidity in psychiatric disorders. In this review paper, we highlight the role of circadian clocks in glucocorticoid, dopamine, and orexin/melanin-concentrating hormone systems, and describe how a dysfunction of these clocks may contribute to the simultaneous development of psychiatric and metabolic symptoms.3

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Diurnal Variation in Regional Brain Glucose Metabolism in Depression

Abstract: Background-This study compared diurnal variation in mood and regional cerebral metabolic rate of glucose (rCMRglc) in depressed and healthy subjects.

Cited by 53 publications

References 43 publications

Using Blood Glucose Estimation to Interpret Stress in Patients Undergoing Minor Oral Surgery Procedures

Using Blood Glucose Estimation to Interpret Stress in Patients Undergoing Minor Oral Surgery Procedures

Chronobiology, excessive daytime sleepiness and depression: Is there a link?

Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders

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