Neuro‐muscular transmission in crabs

Katz, Bernhard

doi:10.1113/jphysiol.1936.sp003401

Cited by 96 publications

(26 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Accordingly it was suggested that curare and atropine act principally on the C.N.S. The lack of actions of cholinergic agents on peripheral tissues in Crustacea was extended and confirmed separately by Katz (1936) and Bacq (1935). ACh, cholinergic receptor blocking agents (curare and atropine again) and an acetylcholinesterase inhibitor (eserine) were found to be without physiological effects on crustacean neuromuscular junctions.…”

Section: Discussionmentioning

confidence: 91%

Acetylcholine and lobster sensory neurones

Barker¹,

Herbert²,

Hildebrand³

et al. 1972

The Journal of Physiology

120

View full text Add to dashboard Cite

SUMMARYExperiments are presented in support of the hypothesis that acetylcholine functions as a sensory transmitter in the lobster nervous system.1. Several different peripheral sensory structures incorporate radioactive choline into acetylcholine. The preparation most enriched in sensory as opposed to other nervous elements (the antennular sense organs of the distal outer flagellum) does not incorporate significant amounts of glutamate, tyrosine or tryptophan into any of the other major transmitter candidates.2. There is a parallel between the distribution of the enzyme choline acetyltransferase and the proportion of sensory fibres in nervous tissue from many parts of the lobster nervous system. 3. Isolated sensory axons contain at least 500 times as much choline acetyltransferase per cm of axon as do efferent excitatory and inhibitory fibres.4. Abdominal ganglia and root stumps show a decline in the rate of incorporation of choline into acetylcholine 2 to 8 weeks after severing the first and second roots bilaterally (leaving the connectives and third roots intact). Extracts of the root stumps exhibit a significantly lower level of choline acetyltransferase 2 weeks after this operation.5. Curare and atropine partially block an identified sensory synapse in the lobster abdominal ganglion.

show abstract

Section: Discussionmentioning

confidence: 91%

Acetylcholine and lobster sensory neurones

Barker¹,

Herbert²,

Hildebrand³

et al. 1972

The Journal of Physiology

120

View full text Add to dashboard Cite

show abstract

“…The electric responses of crustacean muscle increase in amplitude with the frequency of nerve impulses (Katz, 1936;Wiersma, 1941;, and the response produced by a single impulse is generally very small. It was necessary, therefore, to use repetitive stimulation: the frequency was kept at about 30 per sec, adjusted so as to give moderately large potential changes without vigorous mechanical responses.…”

Section: Inhibition Of Crustacean Muscle 375mentioning

confidence: 99%

The effect of inhibitory nerve impulses on a crustacean muscle fibre

Fatt¹,

Katz²

1953

The Journal of Physiology

247

106

View full text Add to dashboard Cite

“…Crustacean muscle is known to have a high potassium content (Scholles, 1933;Katz, 1936), and it is of interest to inquire whether its resting potential is related to the potassium gradient across the fibre membrane, similarly to that in other nerve and muscle tissues.…”

mentioning

confidence: 99%

The electrical properties of crustacean muscle fibres

Fatt¹,

Katz²

1953

The Journal of Physiology

532

221

View full text Add to dashboard Cite

Crustacean muscle has been of special interest to physiologists because its myoneural junctions show the properties of central nervous synapses. The muscles are supplied by excitatory and inhibitory nerve fibres which can be stimulated separately, and whose interaction can be studied at the level of the nerve-muscle junction. As was pointed out in recent reviews (Wiersma, 1941;Katz, 1949), much valuable information has been obtained about the organization of the crustacean nerve-muscle system, but little progress has been made in elucidating the mechanisms by which antagonistic nerve impulses exert their effects on the muscle fibres.As a first step, it seemed necessary to study the properties of crustacean muscle fibres, quite apart from their nerve junctions. Hitherto, most of the elementary properties of the crustacean muscle membrane have remained unexplored, largely because of technical difficulties in obtaining suitable fibre preparations. With the help of intracellular electrodes, this difficulty can be overcome, and in the present work extensive use has been made of this method, for stimulating and recording across the surface membrane of individual muscle fibres.The object of this paper is to present electrical measurements on the crustacean muscle membrane, in particular its resistance and capacity, its resting and action potential, and its electrical reactions in various ionic environments. As was indicated in previous notes (Fatt & Katz, 1951b, 1952, the electric response of crustacean muscle fibres, and especially its persistence in sodium-free media, differs from that of many other excitable tissues, and the evidence for this will be discussed in detail. METHODSApplication of intracelular electrodes. The usual procedure was to introduce two microelectrodes into the same fibre, one to paas current through the membrane, the other to record the membrane potential. The circuits were completed by separate external electrodes whose connexions are shown in Fig. 1. The micro-electrodes were operated by separate manipulators and

show abstract

Neuro‐muscular transmission in crabs

Cited by 96 publications

References 11 publications

Acetylcholine and lobster sensory neurones

Acetylcholine and lobster sensory neurones

The effect of inhibitory nerve impulses on a crustacean muscle fibre

The electrical properties of crustacean muscle fibres

Contact Info

Product

Resources

About