Neuro-Immuno-Endocrine Modulation in Marathon Runners

Bachi, André Luís Lacerda; Ríos, Francisco; Vaisberg, Pedro Henrique Carr; Martins, Marcia Aparecida; Sá, Matheus Cavalcante de; Victorino, A.B.; Foster, Roberta; Sierra, Ana; Kiss, Maria Augusta P. D.; Vaisberg, Mauro

doi:10.1159/000363061

Cited by 17 publications

(24 citation statements)

References 40 publications

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“…A previous study by our group [22] on marathon runners showed that the volunteers had elevated levels of IL-10, IL-8, and growth hormone before the race, suggesting that these cytokines act as protective mechanisms of the central nervous system when submitted to strenuous exercise.…”

Section: Discussionmentioning

confidence: 99%

Premenstrual Syndrome, Inflammatory Status, and Mood States in Soccer Players

Foster

Vaisberg

Bachi

et al. 2019

Neuroimmunomodulation

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Objective: To evaluate the relationship between the inflammatory profile and mood states in the different phases of the menstrual cycle in soccer players with and without premenstrual syndrome (PMS). Methods: Data on the menstrual cycle and mood states were collected using the Daily Symptom Report and the Brunel Mood Scale. Cytokine and stress hormone concentrations were measured in urine by flow cytometry before and after a game in the luteal phase and in the follicular phase of one menstrual cycle. Results: In all, 59.6% of the athletes had PMS. The PMS group showed higher concentrations of interleukin (IL)-1β, IL-6, and IL-8 than the athletes without PMS. After the game, IL-6 decreased in the follicular phase and the luteal phase. The tumor necrosis factor-α levels were higher in the group without PMS during the post-game follicular phase than before the game. In the PMS group, tension was higher in the follicular phase before the game and depression was higher in the pre-game luteal phase than in the group without PMS. The PMS group also presented a negative correlation between depression and IL-10 levels in the pre-game follicular phase. Finally, in the pre-game luteal phase were found positive correlations between growth hormone and IL-10. Conclusion: PMS influences the inflammatory condition related to mood states and stress hormones in female soccer players.

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Section: Discussionmentioning

confidence: 99%

Premenstrual Syndrome, Inflammatory Status, and Mood States in Soccer Players

Foster

Vaisberg

Bachi

et al. 2019

Neuroimmunomodulation

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“…It has been long demonstrated that exercise training induces an alteration in cytokine profile [13][14][15]. However, no evidence could be found in the literature of any study correlating RE to IL-6, a modulatory cytokine, in marathon runners.…”

Section: Discussionmentioning

confidence: 99%

Relationship between cytokines and running economy in marathon runners

Luna

Santos²,

Bachi³

et al. 2016

Open Life Sciences

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BackgroundRunning economy (RE), expresses the relationship between the energy cost of running (Cr) and the work performed by a runner and is an predictor of performance. Given the intense effort of marathon runners during training and competition and the dearth of studies that address performance and cytokines in this population, the objective of the current study was to investigate the relationship between RE and cytokines in marathon runners.MethodsA total of 22 recreational marathon runners were examined. Using data obtained from VO2max assessments and sub-maximal tests, the following formula was applied to determine RE: Cr (mLO2·kg-1·km-1) = VO2 (mL·kg-1·h-1) × 60 ÷ speed (km·h-1).ResultsCr values shows no correlation with levels of the serum IL-1β, IL-4, IL-8, IL-10 and TNF-a 24h before, immediately after or 72h after the completion of an official marathon. However, the IL-6 level shows a significant correlation with Cr.Discussion and conclusionThe relationship between higher values of IL-6 and lower RE leads to the hypothesis of a physical under-recovery state by some athletes. Considering the stress caused by training, associated with the higher energetic cost in less economic athletes, it’s possible that the period of resting may not totally compensate for the inflammatory state.

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“…22 Interleukin 10 (IL-10) is a cytokine that plays an anti-inflammatory role in response to exercise, as well as acting in the brain and behavior, improving mood states. [22][23][24][25] In an attempt to understand these aspects, we proposed to evaluate the levels of anxiety and their connection with IL-10 in a female soccer player group, presenting or not PMS, in four moments: before (pre) and after (post) a simulated game and during the two phases of the menstrual cycle: follicular and luteal.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Anxiety and Interleukin 10 in Female Soccer Players with and Without Premenstrual Syndrome (PMS)

Foster

Vaisberg

Araújo

et al. 2017

Rev Bras Ginecol Obstet

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Objective To investigate the level of anxiety and its relationship with interleukin (IL)-10 (anti inflammatory cytokine that modulates mood swings) in a group of female soccer players. Methods Fifty-two eumenorrheic soccer players were evaluated (age 19.8 AE 4.7 years). The presence of premenstrual syndrome (PMS) and phases of the menstrual cycle were determined by a daily symptom report (DSR) kept for 3 consecutive months. The concentration of cytokine IL-10 was determined from urine samples collected at four moments: at the follicular and luteal phases of the menstrual cycle, and before (pre) and after (post) the simulated game, and it was quantified by flow cytometry (Luminex xMAP -EMD Millipore, Billerica, MA, USA). The level of anxiety was determined through the BAI anxiety questionnaire answered by all athletes at the same time of the urine collection. The Student t-test, analysis of variance (ANOVA) and Pearson correlation with significance level at 5% were used for data analysis. Results We showed that the prevalence of PMS among female soccer players is similar to that reported in the literature. In addition, we showed that the group with PMS has a higher level of anxiety compared with group without PMS (p ¼ 0.002). Interleukin-10 analysis in players without PMS revealed that there was a significant decrease in the level of this cytokine before the game during the luteal phase when compared with the follicular phase (p < 0.05). The correlation analysis between IL-10 and anxiety showed a negative correlation post-game in the luteal phase in the group without PMS (p ¼ 0.02; r ¼ -0.50) and a positive correlation post-game in the luteal phase in PMS group (p ¼ 0.04; r ¼ 0.36).

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Neuro-Immuno-Endocrine Modulation in Marathon Runners

Cited by 17 publications

References 40 publications

Premenstrual Syndrome, Inflammatory Status, and Mood States in Soccer Players

Premenstrual Syndrome, Inflammatory Status, and Mood States in Soccer Players

Relationship between cytokines and running economy in marathon runners

Relationship between Anxiety and Interleukin 10 in Female Soccer Players with and Without Premenstrual Syndrome (PMS)

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