Neuro-endocrine effects of aqueous extract of Amaranthus viridis (Linn.) leaf in male Wistar rat model of cyclophosphamide-induced reproductive toxicity

Ayoka, Oladele A.; Ojo, Opeyemi Esther; Imafidon, Eseigbe Christian; Ademoye, Kehinde Aderonke; Oladele, Abraham Ayowole

doi:10.1016/j.toxrep.2016.07.007

Cited by 24 publications

(19 citation statements)

References 35 publications

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“…There is little understanding of the influence of alkylating agents on the pituitary. Some previous studies reported that cyclophosphamide induced oxidative stress in the brain of mice [22,23], and Ayoka et al reported that the parenchymal cells appeared scanty and hypertrophied in the pituitary of mice exposed to cyclophosphamide [24]. We deduced that the alteration of the histoarchitecture of the pituitary may lead to GHD.…”

Section: Discussionmentioning

confidence: 64%

Factors predicting endocrine late effects in childhood cancer survivors from a Japanese hospital

et al. 2020

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We retrospectively analyzed endocrine late effects in 81 childhood cancer survivor (CCS) patients who had been referred to our endocrinology department in Chiba Children's Hospital between January 1, 2008 and December 31, 2016. Among 69 eligible patients (33 male, 36 female), endocrine late effects were identified in 56 patients (81.1%). The median age at the last visit to our endocrinology department was 17.4 years (range: 7.1-35.3 years). The most common primary cancer was acute lymphoblastic leukemia (22 patients, 31.8%). Forty-four patients (64%) were treated using radiation therapy. A primary brain tumor and high doses (≥6 g/m 2 ) of cyclophosphamide were significantly associated with growth hormone deficiency (GHD). Our present study suggests that high doses of cyclophosphamide is a risk factor for GHD. Adult heights and pubertal growth spurts of patients treated with radiation therapy were significantly lower than patients not treated with radiation therapy. Our retrospective study reconfirmed that hematopoietic stem cell transplantation and chronic graft versus host disease (GVHD) were associated with elevated risks of primary hypothyroidism. However, it is unclear whether GVHD induces thyroid dysfunction. Gonadal radiation and busulfan were associated with primary hypogonadism as reported in previous studies. We found high doses of cyclophosphamide to be involved in pituitary disorders. We suggest that pediatric endocrinologists should discuss the potential effects of radiation therapy on adult height and pubertal growth spurt in CCS patients. Moreover, patients who have been treated with high doses of cyclophosphamide or have chronic GVHD require long-term follow-up for endocrine late effects.

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Section: Discussionmentioning

confidence: 64%

Factors predicting endocrine late effects in childhood cancer survivors from a Japanese hospital

et al. 2020

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“…Reduced glutathione (GSH) is a non‐enzymatic antioxidant marker, while thiobarbituric acid reactive substance (TBARS) is an important index of lipid peroxidation . This study demonstrated that cimetidine administration caused deleterious disturbance of the antioxidant system.…”

Section: Discussionmentioning

confidence: 97%

“…This suggested that AECUL boosted sperm counts by providing protection against the effects of cimetidine. Sperm motility and viability are also important and integral parameters of many reproductive toxicity guidelines . These sperm characterization indices can be affected when a chemical agent penetrates the blood‐testis barrier to cause deleterious changes in the micro‐environment of the seminiferous tubules .…”

Section: Discussionmentioning

confidence: 99%

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Curcuma longa normalized cimetidine‐induced pituitary‐testicular dysfunction: Relevance in nutraceutical therapy

Onwuemene

Imafidon

Ayoka

2019

Anim Models and Exp Med

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Background The increasing incidence of chemically induced infertility is both a social threat and a threat to the continuation of life itself. Treatment or management therapy is often expensive. This study investigated the effects of acetone extract of a local plant (Curcuma longa) in a Wistar rat model of cimetidine‐induced pituitary‐testicular dysfunction. Methods Thirty‐five male Wistar rats were divided into 7 groups of 5 rats. After a phytochemical screening of an acetone extract of C. Longa, cimetidine and the extract at three doses, 200, 400 and 600 mg/kg, were orally co‐administered to the rats for 28 consecutive days. Comparisons were made (at P < 0.05) against a control (2 mL/kg distilled water), a standard treatment group (cimetidine + 50 mg/kg vitamin C), a toxic group (60 mg/kg cimetidine) and a group receiving extract alone. Results Cimetidine administration was associated with deleterious alterations to sperm motility, sperm count and sperm viability, as well as derangements in the plasma levels of FSH, LH and testosterone (P < 0.05). Both brain and testicular GSH and TBARS levels were significantly altered following cimetidine administration, and distortions were seen in the pituitary and testicular histoarchitecture. These changes were significantly normalized by co‐administration of graded doses of the extract, with an associated improvement of both pituitary and testicular histology. Conclusion Acetone extract of C. Longa normalized cimetidine‐induced pituitary‐testicular dysfunction in Wistar rats. This presents the extract as a potential nutraceutical choice against chemically induced reproductive toxicity.

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“…The pharmacological activities of the extract, as demonstrated by vasodilatory and antioxidant-boosting potentials were conferred by its important phytochemicals such as flavonoids, phenolics alkaloids and tannins (Table 3). According to literature, these phytochemicals are reputed to demonstrate antioxidant, anti-inflammatory and membrane-stabilizing properties both invivo and invitro [58][59][60].…”

Section: Discussionmentioning

confidence: 99%

Aqueous garlic extract improves renal clearance via vasodilatory/antioxidant mechanisms and mitigated proteinuria via stabilization of glomerular filtration barrier

et al. 2019

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Background: Lead (Pb) remains an apparently indispensable material in several industrial processes. It is a potent environmental toxin with associated deleterious biological effects. The study investigated the effects of aqueous garlic extract (AGE) on renal clearance and proteinuria in Wistar rats with Pb-induced kidney injury.Methods: Thirty male Wistar rats were divided into six groups of five rats each such that exposure to Pb (35 mg/kg i.p) for 10 consecutive days was either followed by 30 days recovery period (without treatment) or 30 days post-treatment with oral graded doses of AGE at 100, 200 and 400 mg/kg while comparisons where made against a control (2 ml/kg NORMAL SALINE) at p < 0.05. The phytochemical constituents of the extract were determined using conventional standard protocols before administration to the rats.Results: Pb toxicity induced deleterious alterations of renal function biomarkers (creatinine, urea and total protein) in the plasma and urine, indicators of oxidative stress and lipid peroxidation (GSH, SOD, CAT and TBARS) in the kidney tissues as well as significantly lowered plasma and kidney NO level (p < 0.05) of the rats. It also significantly lowered creatinine clearance and fractional excretion of urea while urine total protein-creatinine ratio was significantly increased in the rats. Kidney histology showed evidence of Pb-induced glomerular atrophy with tubular and interstitial vacuolation. However, AGE administration was associated with significant normalization of the aforementioned biochemical parameters (p < 0.05) as well as kidney histoarchitectural improvement. The pharmacological effects of AGE were attributed to its determined phytochemical constituents. Conclusion: AGE normalized renal clearance through vasodilatory and antioxidant mechanisms with associated mitigation of proteinuria through stabilization of glomerular filtration barrier.

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Neuro-endocrine effects of aqueous extract of Amaranthus viridis (Linn.) leaf in male Wistar rat model of cyclophosphamide-induced reproductive toxicity

Cited by 24 publications

References 35 publications

Factors predicting endocrine late effects in childhood cancer survivors from a Japanese hospital

Factors predicting endocrine late effects in childhood cancer survivors from a Japanese hospital

Curcuma longa normalized cimetidine‐induced pituitary‐testicular dysfunction: Relevance in nutraceutical therapy

Aqueous garlic extract improves renal clearance via vasodilatory/antioxidant mechanisms and mitigated proteinuria via stabilization of glomerular filtration barrier

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