Neural Tube Defects in Algeria

Houcher, Bakhouche; Begag, Samia; Eğin, Yonca; Akar, Nejat

doi:10.5772/30950

Cited by 11 publications

(9 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is also higher than all European countries (EUROCAT) [ 28 , 29 ] and many Southeast Asian regions including Bangladesh (13.8 per 10,000) [ 30 ]; Eastern India (17.8 per 10,000) [ 31 ]; Nepal (11.9 per 10,000) [ 32 ]; and Bangkok, Thailand (6.3 per 10,000) [ 33 ]. Reports of similar prevalence to our study have emerged from Northern China (199.4 per 10,000 births) [ 34 ]; Eastern Saudi Arabia (53.5 per 10,000) [ 35 ]; Jordan (62.9 per 10,000) [ 36 ]; Iran (82.9 per 10,000) [ 37 ]; and Algeria (75.4 per 10,000) [ 38 ]. Consistently high prevalence of NTDs similar to our study has also been reported in Swat (124 per 10,000) [ 39 ] and Abbottabad (68.8 per 10,000) [ 40 ] regions of Pakistan.…”

Section: Discussionsupporting

confidence: 85%

Magnitude of Neural Tube Defects and Associated Risk Factors at Three Teaching Hospitals in Addis Ababa, Ethiopia

Gedefaw

Teklu

Tadesse

2018

BioMed Research International

111

View full text Add to dashboard Cite

There is scarcity of data on prevalence of neural tube defects (NTDs) in lower-income countries. Local data are important to understand the real burden of the problem and explore risk factors to design and implement preventive approaches. This study aimed to determine prevalence and risk factors of NTDs. A hospital-based cross-sectional and unmatched case-control study was conducted at three teaching hospitals of Addis Ababa University. NTDs were defined as cases of anencephaly, spina bifida, and encephalocele based on ICD-10 criteria. The prevalence of NTDs was calculated per 10,000 births for both birth and total prevalence. During seven months, we observed 55 cases of NTDs out of 8677 births after 28 weeks of gestation—birth prevalence of 63.4 per 10,000 births (95% confidence interval (CI), 51–77). A total of 115 cases were medically terminated after 12 weeks of gestation. Fifty-six of these terminations (48.7%) were due to NTDs. Thus, total prevalence of NTDs after 12 weeks' gestation is 126 per 10,000 births (95% CI, 100–150). Planned pregnancy (adjusted odds ratio (aOR), 0.47; 95% CI, 0.24–0.92), male sex (aOR, 0.56; 95% CI, 0.33–0.94), normal or underweight body mass index (aOR, 0.49; 95%, 0.29–0.95), and taking folic acid or multivitamins during first trimester (aOR, 0.47; 95%, 0.23–0.95) were protective of NTDs. However, annual cash family income less than $1,300 USD (aOR, 2.5; 95%, 1.2–5.5), $1,300–1,800 USD (aOR, 2.8; 95%, 1.3–5.8), and $1,801–2,700 USD (aOR, 2.6; 95%, 1.2–5.8) was found to be risk factors compared to income greater than $2,700 USD. The prevalence of NTDs was found to be high in this setting. Comprehensive preventive strategies focused on identified risk factors should be urgently established. More studies on prevention strategies, including folic acid supplementations, should be conducted in the setting.

show abstract

Section: Discussionsupporting

confidence: 85%

Magnitude of Neural Tube Defects and Associated Risk Factors at Three Teaching Hospitals in Addis Ababa, Ethiopia

Gedefaw

Teklu

Tadesse

2018

BioMed Research International

111

View full text Add to dashboard Cite

show abstract

“…This systematic review demonstrates great variability in reported NTD prevalence estimates globally (range: 0.3–199.4 per 10,000 births) ( Table 1 ) [ 19 – 124 ]. Of note, both the lowest and highest point estimates in this global range came from studies conducted in different regions of China; Beijing [ 113 ] and Luliang [ 112 ], respectively.…”

Section: Resultsmentioning

confidence: 99%

“…African Region: Data from eight of 47 WHO member countries, represented by 11 studies, met our inclusion criteria ( Fig 5 ). The lowest reported NTD prevalence for the region was reported in Nigeria (5.2 per 10,000 births) [ 24 ] and the highest was reported in Algeria (75.4 per 10,000 births) [ 19 ]. The median NTD prevalence was 11.7 per 10,000 births.…”

Section: Resultsmentioning

confidence: 99%

Describing the Prevalence of Neural Tube Defects Worldwide: A Systematic Literature Review

et al. 2016

View full text Add to dashboard Cite

BackgroundFolate-sensitive neural tube defects (NTDs) are an important, preventable cause of morbidity and mortality worldwide. There is a need to describe the current global burden of NTDs and identify gaps in available NTD data.Methods and FindingsWe conducted a systematic review and searched multiple databases for NTD prevalence estimates and abstracted data from peer-reviewed literature, birth defects surveillance registries, and reports published between January 1990 and July 2014 that had greater than 5,000 births and were not solely based on mortality data. We classified countries according to World Health Organization (WHO) regions and World Bank income classifications. The initial search yielded 11,614 results; after systematic review we identified 160 full text manuscripts and reports that met the inclusion criteria. Data came from 75 countries. Coverage by WHO region varied in completeness (i.e., % of countries reporting) as follows: African (17%), Eastern Mediterranean (57%), European (49%), Americas (43%), South-East Asian (36%), and Western Pacific (33%). The reported NTD prevalence ranges and medians for each region were: African (5.2–75.4; 11.7 per 10,000 births), Eastern Mediterranean (2.1–124.1; 21.9 per 10,000 births), European (1.3–35.9; 9.0 per 10,000 births), Americas (3.3–27.9; 11.5 per 10,000 births), South-East Asian (1.9–66.2; 15.8 per 10,000 births), and Western Pacific (0.3–199.4; 6.9 per 10,000 births). The presence of a registry or surveillance system for NTDs increased with country income level: low income (0%), lower-middle income (25%), upper-middle income (70%), and high income (91%).ConclusionsMany WHO member states (120/194) did not have any data on NTD prevalence. Where data are collected, prevalence estimates vary widely. These findings highlight the need for greater NTD surveillance efforts, especially in lower-income countries. NTDs are an important public health problem that can be prevented with folic acid supplementation and fortification of staple foods.

show abstract

“…The rest 62 articles were screened for the full text, and 24 were excluded due to the outcome of interest (include studies such as risk factor studies, clinical pattern and management studies, and prevention or maternal awareness studies). Therefore, 38 full-text articles were accessed and assessed for eligibility criteria (one study was excluded [ 26 ] due to the similarity of the finding from their previous study). Finally, 27 studies fulfilled the eligibility criteria and were included in the systematic review and meta-analysis ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Spina Bifida among Newborns in Africa: A Systematic Review and Meta-Analysis

et al. 2020

View full text Add to dashboard Cite

Spina bifida is an abnormal closure of the neural tube during the fourth week of development. It is the major cause of fetal loss and considerable disabilities in newborns. The aim of this review is to determine the pooled prevalence of spina bifida among newborns in Africa. PubMed/Medline, Google Scholar, Science Direct, Joanna Briggs Institute (JBI) Library, Cochrane Library, Web of Science, African Journals Online, and Embase databases were systematically searched. Cochran Q test and I2 test statistics were applied to assess heterogeneity across studies. A random-effect model was applied to calculate the pooled prevalence of spina bifida. Forest plot and Galbraith’s plot were used to visualize heterogeneity. Subgroup, sensitivity, meta-regression, and meta-cumulative analyses were performed. All essential data were extracted using a standardized data extraction format, and the JBI quality appraisal checklist was used to assess the quality of studies. Egger’s test and Begg’s test were used in order to detect the publication bias. In the present systematic review and meta-analysis, 6,587,298 births in twenty-seven studies were included. The pooled birth prevalence of spina bifida in Africa was 0.13% with a range between 0.12% and 0.14%. In Africa, the highest burden of spina bifida was detected in Algeria (0.43%), Ethiopia (0.32%), Tanzania (0.26%), Cameron (0.12%), Egypt (0.10%), and South Africa (0.10%). The lowest burden of spina bifida was detected in Libya (0.006%) and Tunisia (0.009%). The high birth prevalence of spina bifida was detected in Africa. There was a significant variation in the prevalence of spina bifida among study countries in Africa. The authors recommend that special awareness creation with the help of health education intervention should be provided for mothers to focus on prevention in order to reduce the burden of spina bifida.

show abstract

Neural Tube Defects in Algeria

Cited by 11 publications

References 67 publications

Magnitude of Neural Tube Defects and Associated Risk Factors at Three Teaching Hospitals in Addis Ababa, Ethiopia

Magnitude of Neural Tube Defects and Associated Risk Factors at Three Teaching Hospitals in Addis Ababa, Ethiopia

Describing the Prevalence of Neural Tube Defects Worldwide: A Systematic Literature Review

Prevalence of Spina Bifida among Newborns in Africa: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About