Neural stem cells transplantation in cortex in a mouse model of Alzheimer’s disease

Neural Stem Cells Improve Learning and Memory in Rats with Alzheimer’s Disease

“…The formation of A ␤ and the accumulation of NFT in the brain trigger the pathological cascade of AD, including the degeneration of neuronal elements [46,47] . Intravenously delivered NSC were recently suggested to reduce progressive AD [48,49] , and transplantation studies using NSC have shown site-specific neuronal differentiation in neurogenesis sites of the adult brain [50] . NSC also show remarkable plasticity and an ability to respond to epigenetic signals in vivo by generating region-specific neurons [51][52][53] .…”

ABC transporters, neural stem cells and neurogenesis – a different perspective

“…While their exact function and distribution is currently being assessed, they represent an interesting cell population, which may be used to study factors important for the differentiation and characterization of neurons, astrocytes and oligodendrocytes. Recently, there have been reports of NSC transplantations attempting to achieve functional recovery from CNS damage [171][172][173][174][175][176], and recent evidence suggests that NSCs may be a suitable source for the treatment of neurological diseases [22][23][24][25][26][27][177][178][179]. Due to their proliferative and differentiation capacity, NSCs will be important in fighting numerous brain disorders like AD, PD and Huntington's disease, as well as spinal cord disorders.…”

Embryonic Stem Cell in the Therapy of Neurodegenerative Diseases

“…However, it is difficult to get enough donor cells, no clinical trials in AD patients have been initiated with this method (Fine et al, 1985). When ESCs as donor cells transplanted directly in AD animal model, it usually resulted in teratomas formation instead of producing neurons (Ringdén et al, 2003;Wang et al, 2006). However, ESCs-derived neurospheres, NPCs and neurons transplantation were evaluated in animal models and proved to be safe.…”

“…However, ESCs-derived neurospheres, NPCs and neurons transplantation were evaluated in animal models and proved to be safe. Wang and colleagues has demonstrated that ESCsderived neurospheres transplanted into frontal cortex of Meynert nucleus lesion mouse model survived and produced many ChAT-positive neurons and a few serotonin-positive neurons in and around the grafts, and the improved working memory was also observed after transplantation (Wang et al, 2006). Moghadam and colleagues further implanted primed and unprimed mouse ESCs-derived NPCs into the unilateral nbM of rat model of AD, Morris water maze and spatial probe test revealed a significant behavioral improvement in memory deficits following cells transplantation.…”