Neural sensitivity to novel sounds in the rat's dorsal cortex of the inferior colliculus as revealed by evoked local field potentials

Patel, Chirag; Redhead, Carmela; Cervi, Andrea; Zhang, Huiming

doi:10.1016/j.heares.2012.02.007

Cited by 39 publications

(43 citation statements)

References 57 publications

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“…It has yet to be determined whether GABA B receptors in the rat's IC can also cause these types of plastic changes in synaptic responses. In response to sounds, neurons in the IC display a type of short-term plastic change termed stimulus-specific adaptation (SSA) (Pérez-González et al, 2005, 2012; Malmierca et al, 2009a; Lumani and Zhang, 2010; Patel et al, 2012). These neurons reduce their sensitivity to sounds over repetitive presentations and increase the sensitivity when novel sounds are presented in the acoustic environment.…”

Section: Discussionmentioning

confidence: 99%

“…Among the three subdivisions of the IC, the ICd and ICx have more neurons showing high-degree of SSA. In the ICd, the generation of SSA is likely dependent on inhibitory events that are slightly delayed but long lasting compared with excitatory events (Patel et al, 2012). The relatively slow time course of activation of the GABA B receptor makes it an ideal candidate for mediating these long-lasting inhibitory events.…”

Section: Discussionmentioning

confidence: 99%

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The level and distribution of the GABABR1 and GABABR2 receptor subunits in the rat's inferior colliculus

Jamal¹,

Khan²,

Butt³

et al. 2012

Front. Neural Circuits

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The type B γ-aminobutyric acid receptor (GABAB receptor) is an important neurotransmitter receptor in the midbrain auditory structure, the inferior colliculus (IC). A functional GABAB receptor is a heterodimer consisting of two subunits, GABABR1 and GABABR2. Western blotting and immunohistochemical experiments were conducted to examine the expression of the two subunits over the IC including its central nucleus, dorsal cortex, and external cortex (ICc, ICd, and ICx). Results revealed that the two subunits existed in both cell bodies and the neuropil throughout the IC. The two subunits had similar regional distributions over the IC. The combined level of cell body and neuropil labeling was higher in the ICd than the other two subdivisions. Labeling in the ICc and ICx was stronger in the dorsal than the ventral regions. In spite of regional differences, no defined boundaries were formed between different areas. For both subunits, the regional distribution of immunoreactivity in the neuropil was parallel to that of combined immunoreactivity in the neuropil and cell bodies. The density of labeled cell bodies tended to be higher but sizes of cell bodies tended to be smaller in the ICd than in the other subdivisions. No systematic regional changes were found in the level of cell body immunoreactivity, except that GABABR2-immunoreactive cell bodies in the ICd had slightly higher optic density (OD) than in other regions. Elongated cell bodies existed throughout the IC. Many labeled cell bodies along the outline of the IC were oriented in parallel to the outline. No strong tendency of orientation was found in labeled cell bodies in ICc. Regional distributions of the subunits in ICc correlated well with inputs to this subdivision. Our finding regarding the contrast in the level of neuropil immunoreactivity among different subdivisions is consistent with the fact that the GABAB receptor has different pre- and postsynaptic functions in different IC regions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The level and distribution of the GABABR1 and GABABR2 receptor subunits in the rat's inferior colliculus

Jamal¹,

Khan²,

Butt³

et al. 2012

Front. Neural Circuits

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“…While SSA in the IC was originally described from the neuronal responses using extracellular recordings in animals ( Figures 2 and 3 ), including local field potentials (von der Behrens et al, 2009; Patel et al, 2012), a correlate has been found measuring ERP in the human auditory brainstem ( Figure 4 ) using the frequency-following response (Slabu et al, 2012), showing that the human IC is able to detect a novel acoustic event occurring among a series of repetitive ones. This is supported by the attenuated human brainstem response (see Figures 4 and 5 ) to a stimulus occurring with a low probability compared with that elicited by the same physical stimulus presented with much higher probability.…”

Section: Adaptation Becomes More Diverse Along the Auditory Hierarchymentioning

confidence: 99%

Adaptation in the auditory system: an overview

Pérez-González

Malmierca

2014

Front. Integr. Neurosci.

147

127

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The early stages of the auditory system need to preserve the timing information of sounds in order to extract the basic features of acoustic stimuli. At the same time, different processes of neuronal adaptation occur at several levels to further process the auditory information. For instance, auditory nerve fiber responses already experience adaptation of their firing rates, a type of response that can be found in many other auditory nuclei and may be useful for emphasizing the onset of the stimuli. However, it is at higher levels in the auditory hierarchy where more sophisticated types of neuronal processing take place. For example, stimulus-specific adaptation, where neurons show adaptation to frequent, repetitive stimuli, but maintain their responsiveness to stimuli with different physical characteristics, thus representing a distinct kind of processing that may play a role in change and deviance detection. In the auditory cortex, adaptation takes more elaborate forms, and contributes to the processing of complex sequences, auditory scene analysis and attention. Here we review the multiple types of adaptation that occur in the auditory system, which are part of the pool of resources that the neurons employ to process the auditory scene, and are critical to a proper understanding of the neuronal mechanisms that govern auditory perception.

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“…SSA was first described in the cat primary auditory cortex and suggested to be an emergent property of the auditory cortex (Ulanovsky, et al, 2003). But a series of recent studies of cortical IC neurons (i.e., non-lemniscal neurons of the IC) have demonstrated that the great majority of these cortical IC neurons exhibit SSA, display transient onset responses and have low or absent spontaneous activity in anesthetized rats Pérez-González and Malmierca, 2012;Malmierca et al, 2009b, Lumani andZhao et al, 2011;Duque et al, 2012;Patel et al, 2012) and that they do not inhereit their SSA sensitivity from the auditory cortex (Anderson and Malmierca, 2013). Another feature of the neurons that exhibit SSA is their broad frequency response area (Malmierca et al, 2009a;Duque et al, 2012) and, as described above, neurons in the DCIC and RCIC regions possess widespread dendritic arbors , and broader frequency tuning than those in the CIC .…”

Section: Neurochemistry and Electrophysiological Responses And Functimentioning

confidence: 99%

Auditory System

Malmierca

2015

The Rat Nervous System

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Neural sensitivity to novel sounds in the rat's dorsal cortex of the inferior colliculus as revealed by evoked local field potentials

Cited by 39 publications

References 57 publications

The level and distribution of the GABABR1 and GABABR2 receptor subunits in the rat's inferior colliculus

The level and distribution of the GABABR1 and GABABR2 receptor subunits in the rat's inferior colliculus

Adaptation in the auditory system: an overview

Auditory System

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