Neural functional organization of hallucinations in schizophrenia: Multisensory dissolution of pathological emergence in consciousness

Jardri, Renaud; Pins, Delphine; Bubrovszky, Maxime; Lucas, Bart; Lethuc, V; Delmaire, Christine; Vantyghem, Vincent; Despretz, Pascal; Thomas, Pierre

doi:10.1016/j.concog.2008.12.009

Cited by 47 publications

(22 citation statements)

References 40 publications

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“…Moreover, amodal (Brock et al, 2002) and multisensory (Foss-Feig et al, 2010; Kwakye et al, 2011) timing deficits have been demonstrated in individuals with ASD, and may be associated with morphological (Courchesne et al, 1988; Courchesne, 1995; Mitchell et al, 2009) and functional (Mostofsky et al, 2009) changes in the superior cerebellum that correlate with disease severity. Lastly, it is clear that both multisensory processing (Ross et al, 2007; de Jong et al, 2009; Jardri et al, 2009) and pSTS activity during audiovisual speech binding (Szycik et al, 2009) is altered in individuals with schizophrenia when compared with matched controls. Given that these deficits and the plastic changes demonstrated here are likely to be reflective of changes in local neural architecture (Brock et al, 2002), these results point to multisensory temporal training as an especially promising new avenue for exploration of the contribution of multisensory processing to these disorders.…”

Section: Discussionmentioning

confidence: 99%

Neural Correlates of Multisensory Perceptual Learning

Powers

Hevey²,

Wallace³

2012

J. Neurosci.

136

128

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The brain’s ability to bind incoming auditory and visual stimuli depends critically on the temporal structure of this information. Specifically, there exists a temporal window of audiovisual integration within which stimuli are highly likely to be perceived as part of the same environmental event. Several studies have described the temporal bounds of this window, but few have investigated its malleability. Recently, our laboratory has demonstrated that a perceptual training paradigm is capable of eliciting a 40% narrowing in the width of this window that is stable for at least one week after cessation of training. In the current study we sought to reveal the neural substrates of these changes. Eleven human subjects completed an audiovisual simultaneity judgment training paradigm, immediately before and after which they performed the same task during an event-related 3T fMRI session. The posterior superior temporal sulcus (pSTS) and areas of auditory and visual cortex exhibited robust BOLD decreases following training, and resting state and effective connectivity analyses revealed significant increases in coupling among these cortices after training. These results provide the first evidence of the neural correlates underlying changes in multisensory temporal binding and that likely represent the substrate for a multisensory temporal binding window.

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Section: Discussionmentioning

confidence: 99%

Neural Correlates of Multisensory Perceptual Learning

Powers

Hevey²,

Wallace³

2012

J. Neurosci.

136

128

View full text Add to dashboard Cite

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“…For example, many clinical symptoms in schizophrenia seem to be the result of a pathological connectivity between cortical networks, including between sensory processing networks, during cognitive tasks [78]. It is therefore possible, perhaps even likely, that an altered interplay between attention and multisensory processes will be found in this group of patients [79].…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

The multifaceted interplay between attention and multisensory integration

Talsma

Senkowski

Soto‐Faraco

et al. 2010

Trends in Cognitive Sciences

672

606

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Multisensory integration has often been characterized as an automatic process. Recent findings suggest that multisensory integration can occur across various stages of stimulus processing that are linked to, and can be modulated by, attention. Stimulus-driven, bottom-up mechanisms induced by cross-modal interactions can automatically capture attention towards multisensory events, particularly when competition to focus elsewhere is relatively low. Conversely, top-down attention can facilitate the integration of multisensory inputs and lead to a spread of attention across sensory modalities. These findings point to a more intimate and multifaceted interplay between attention and multisensory integration than was previously thought. We review developments in our understanding of the interactions between attention and multisensory processing, and propose a framework that unifies previous, apparently discordant findings.

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“…Auditory hallucinations in schizophrenia increase the hemodynamic response in the bilateral insula (Shergill et al 2000, Sommer et al 2008, Jardri et al 2009). Response of the left insula has been reported to occur shortly before a hallucination or as the subject becomes aware of it (Hoffman et al 2008, Shergill et al 2004).…”

Section: Putting It All Together: the Insula And The Etiology Of Hmentioning

confidence: 99%

The role of the insula in schizophrenia

Wylie

Tregellas

2010

Schizophrenia Research

295

188

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Involvement of the insular cortex is a common finding in neuroanatomical studies of schizophrenia, yet its contribution to disease pathology remains unknown. This review describes the normal function of the insula and examines pathology of this region in schizophrenia. The insula is a cortical structure with extensive connections to many areas of the cortex and limbic system. It integrates external sensory input with the limbic system and is integral to the awareness of the body's state (interoception). Many deficits observed in schizophrenia involve these functions and may relate to insula pathology. Furthermore, reports describing deficits caused by lesions of the insula parallel deficits observed in schizophrenia. Examples of insula-related functions that are altered in schizophrenia include the processing of both visual and auditory emotional information, pain, and neuronal representations of the self. The last of these functions, processing representations of the self, plays a key role in discriminating between self-generated and external information, suggesting that insula dysfunction may contribute to hallucinations, a cardinal feature of schizophrenia.

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Neural functional organization of hallucinations in schizophrenia: Multisensory dissolution of pathological emergence in consciousness

Cited by 47 publications

References 40 publications

Neural Correlates of Multisensory Perceptual Learning

Neural Correlates of Multisensory Perceptual Learning

The multifaceted interplay between attention and multisensory integration

The role of the insula in schizophrenia

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