Neural Dysconnectivity in the Hippocampus Correlates With White Matter Lesions and Cognitive Measures in Patients With Coronary Artery Disease

Abstract

PurposeRecent neuroimaging reports have shown the microstructural changes in coronary artery disease (CAD) and its correlation with cognitive dysfunction while little is known about the functional characteristics of CAD. We hypothesize that functional characteristics may give clues to underlying pathology in CAD and its link with cognitive dysfunction. Degree centrality (DC), a graph-based assessment of network organization was performed to explore the neural connectivity changes in CAD patients compared with healthy controls and their correlation with cognitive measures.MethodsThirty CAD patients and 36 healthy controls were included in our study. All participants underwent functional magnetic resonance imaging (fMRI) of the brain. We performed DC analysis to identify voxels that showed changes in whole-brain functional connectivity with other voxels. DC was measured by the fMRI graph method and comparisons between the two groups were done. All participants underwent neuropsychological assessment (Montreal Cognitive Assessment, MoCA and Mini-Mental State Examination, MMSE).ResultsOur data analysis included 30 CAD patients (59.90 ± 7.53 years) and 36 HCs (61.61 ± 6.19 years). CAD patients showed a greater prevalence of white matter lesions using the Fazekas score than healthy controls (P < 0.001). Importantly, CAD patients showed significantly lower (P < 0.001) MoCA and MMSE scores compared with healthy controls. CAD patients showed significantly decreased DC value (P < 0.001) in the right hippocampus (hippocampus_R), right lingual gyrus (lingual_R), and significantly increased DC value (P < 0.001) in the left middle frontal gyrus (Frontal_Mid_L) when compared with healthy controls respectively. DC value in the hippocampus_R significantly correlated (P < 0.00) with MMSE and MoCA scores in CAD patients. Fazekas scores in CAD patients showed a significant correlation (P < 0.001) with the DC value in the hippocampus_R.ConclusionThese findings suggest that reduced cerebral neural connectivity in CAD may contribute to their cognitive impairment and white matter microstructural damage.

Genetic influences on the shape of brain ventricular and subcortical structures

“…4D). CAD had long-term negative impact on brain health and reduced neural connectivity changes in the hippocampus were observed in CAD and may contribute to cognitive impairment 98 . A significant genetic correlation between AD and the hippocampus was not observed.…”

Cognitive function and cardiovascular health in the elderly: network analysis based on hypertension, diabetes, cerebrovascular disease, and coronary heart disease

“…With the deepening of pathophysiological research in recent years, researchers have discovered that different vascular factors have varying mechanisms of damaging cognitive function. They produce different inflammatory factors and endogenous hormones, which bind to their corresponding receptors, leading to impaired synaptic, metabolic, and immune responses, and cause differences in brain structure and neural connections (Skoog et al, 1996;Langbaum et al, 2012;Love and Miners, 2016;Niu et al, 2022). For instance, hypertension may impact cognitive function by influencing cerebral blood flow and causing cerebral microvascular damage (Ungvari et al, 2021), while diabetes primarily results in the accumulation of abnormally folded amyloid-beta peptide (Aβ) and tau protein in amyloid plaques and neurofibrillary tangles, as well as various forms of vascular injury (Moran et al, 2015;Xue et al, 2019).…”