Neural Correlates of Altered Pain Response in Women with Posttraumatic Stress Disorder from Intimate Partner Violence

Strigo, Irina A.; Simmons, Alan N.; Matthews, Scott C.; Grimes, Erin M.; Allard, Carolyn B.; Reinhardt, Lindsay E.; Paulus, Martin P.; Stein, Murray B.

doi:10.1016/j.biopsych.2010.03.034

Cited by 101 publications

(79 citation statements)

References 64 publications

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“…Extant genetic association studies of PTSD often produced inconsistent results (Cornelis et al, 2010), and the heterogeneity and complexity of the PTSD phenotype may be one of the important factors responsible for these inconsistencies. The PTSD phenotype is comprised of different types of symptom clusters that may be associated with different psychopathological and biological processes (Asmundson et al, 2004;O'Donnell et al, 2004;Strigo et al, 2010). To reduce the heterogeneity of a complex mental disorder such as PTSD and to increase the chances of identifying distinct contributions by the specific genes, an alternative approach is using more homogeneous symptom clusters as alternative phenotypes in further genetic research (Rietkerk et al, 2008), which demonstrated to be promising (Rietkerk et al, 2008;Labbe et al, 2012;van Veen et al, 2012).…”

Section: Discussionmentioning

confidence: 98%

TPH2 genotype is associated with PTSD’s avoidance symptoms in Chinese female earthquake survivors

Cao

Wang

et al. 2014

Psychiatric Genetics

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Genetic factors are important in the development of post-traumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder have not been definitive. This study examined the association between tryptophan hydroxylase 2 (TPH2) rs11178997 genotype, a single-nucleotide polymorphism (SNP) located in the transcriptional control region, and PTSD symptoms. A total of 326 Chinese adults who suffered from the deadly 2008 Wenchuan earthquake and lost their children during the disaster participated in this study. PTSD symptoms were measured with PTSD checklist, and the SNP was successfully genotyped by the MassARRAY system. The results indicated that, although the rs11178997 genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's avoidance symptoms in women. These findings support that TPH2 may play an important functional role in the development of PTSD and contribute to the limited literature regarding the genetic basis and the sex-specific expression of PTSD's symptoms.

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Section: Discussionmentioning

confidence: 98%

TPH2 genotype is associated with PTSD’s avoidance symptoms in Chinese female earthquake survivors

Cao

Wang

et al. 2014

Psychiatric Genetics

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“…Our findings are consistent with studies that used trauma-event-script-driven imagery with SPECT (Lindauer et al, 2008) and fMRI (Lanius et al, 2007), as well as with studies that used emotional and trauma-unrelated stimuli with PET and fMRI (Hughes and Shin, 2011). Painful stimuli have also been shown to increase insular activity in PTSD (Geuze et al, 2007; Strigo et al, 2010). The insular cortex processes information about the body's internal state and contributes to the autonomic component of the overall pain response.…”

Section: Discussionmentioning

confidence: 99%

Voxel-wise resting-state MEG source magnitude imaging study reveals neurocircuitry abnormality in active-duty service members and veterans with PTSD

Huang

Yurgil

Robb

et al. 2014

NeuroImage: Clinical

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Post-traumatic stress disorder (PTSD) is a leading cause of sustained impairment, distress, and poor quality of life in military personnel, veterans, and civilians. Indirect functional neuroimaging studies using PET or fMRI with fear-related stimuli support a PTSD neurocircuitry model that includes amygdala, hippocampus, and ventromedial prefrontal cortex (vmPFC). However, it is not clear if this model can fully account for PTSD abnormalities detected directly by electromagnetic-based source imaging techniques in resting-state. The present study examined resting-state magnetoencephalography (MEG) signals in 25 active-duty service members and veterans with PTSD and 30 healthy volunteers. In contrast to the healthy volunteers, individuals with PTSD showed: 1) hyperactivity from amygdala, hippocampus, posterolateral orbitofrontal cortex (OFC), dorsomedial prefrontal cortex (dmPFC), and insular cortex in high-frequency (i.e., beta, gamma, and high-gamma) bands; 2) hypoactivity from vmPFC, Frontal Pole (FP), and dorsolateral prefrontal cortex (dlPFC) in high-frequency bands; 3) extensive hypoactivity from dlPFC, FP, anterior temporal lobes, precuneous cortex, and sensorimotor cortex in alpha and low-frequency bands; and 4) in individuals with PTSD, MEG activity in the left amygdala and posterolateral OFC correlated positively with PTSD symptom scores, whereas MEG activity in vmPFC and precuneous correlated negatively with symptom score. The present study showed that MEG source imaging technique revealed new abnormalities in the resting-state electromagnetic signals from the PTSD neurocircuitry. Particularly, posterolateral OFC and precuneous may play important roles in the PTSD neurocircuitry model.

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“…Brain regions showing a higher regional cerebral blood flow (rCBF) in S compared with NS (top) ; a positive correlation between CBF and IES scores (mid) ; a negative correlation between CBF and WHO-10 scores (bottom) S, Post-traumatic stress disorder patients ; NS, traumatized control subjects ; IES, Impact of Event Scale ; WHO-10, World Health Organization (10) Well-Being Index ; BA, Brodmann area ; TAL, Talairach coordinates ; p(cor), statistical significance at cluster-level (whole-brain corrected) ; K, cluster size ; Z, z-scores ; p(unc), statistical significance at voxel-level (uncorrected). associated with flashback intensity (Osuch et al 2001), re-experiencing symptom severity (Hopper et al 2007) and avoidance symptoms (Strigo et al 2010) and that grey matter density reduction in this region directly correlates with trauma load (Nardo et al 2010). In addition, it was shown that both anterior and posterior insular activity correlated with alexithymia scores (Frewen et al 2008).…”

Section: Insular Cortexmentioning

confidence: 96%

Self-rating scales assessing subjective well-being and distress correlate with rCBF in PTSD-sensitive regions

et al. 2011

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Background. The aim of this study was to investigate the distribution of the regional cerebral blood flow (rCBF) in occupational-related post-traumatic stress disorder (PTSD) subjects and to seek possible correlations between brain perfusion and self-rating scales (SRS) in order to cross-check their diagnostic value and to look for their neural correlates. Method.A total of 13 traumatized underground and long-distance train drivers developing (S) and 17 not developing (NS) PTSD who had experienced a ' person under train ' accident or who had been assaulted at work underwent clinical assessment and 99m Tc-HMPAO SPECT imaging during autobiographical trauma scripts. Statistical parametric mapping was applied to analyse rCBF changes in S as compared with NS and to search for correlations between rCBF and the administered SRS scores, modelling age, months to SPECT and the ratio ' grey matter/intracranial volume ' as nuisance variables.Results. Significantly higher activity was observed during trauma script in left posterior and anterior insula, posterior cingulate, inferior parietal lobule, precuneus, caudate and putamen in PTSD subjects as compared with the trauma-exposed control group. Impact of Event Scale and World Health Organisation (10) Well-Being Index scores highly correlated with tracer uptake to a great extent in the same regions in which rCBF differences between S and NS were found.Conclusions. These findings support the involvement of insular, cingulate and parietal cortices (as well as the basal ganglia) in the pathogenesis of PTSD and in the processing of related subjective well-being and distress.

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Neural Correlates of Altered Pain Response in Women with Posttraumatic Stress Disorder from Intimate Partner Violence

Cited by 101 publications

References 64 publications

TPH2 genotype is associated with PTSD’s avoidance symptoms in Chinese female earthquake survivors

TPH2 genotype is associated with PTSD’s avoidance symptoms in Chinese female earthquake survivors

Voxel-wise resting-state MEG source magnitude imaging study reveals neurocircuitry abnormality in active-duty service members and veterans with PTSD

Self-rating scales assessing subjective well-being and distress correlate with rCBF in PTSD-sensitive regions

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