Neural circuitry of play fighting in golden hamsters

Cheng, Shao Ying; Taravosh-Lahn, Kereshmeh; Delville, Yvon

doi:10.1016/j.neuroscience.2008.07.048

Cited by 49 publications

(52 citation statements)

References 61 publications

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“…These findings are consistent with the BNST's role in LUST circuitry; however, this decline appears to be accompanied by an overall reduction in aggressive flank marking behavior in rodents (Albers, Liou, & Ferris, 1988). In contrast, other studies have found that reduced AVP expression within the BNST is correlated with a reduction in intermale aggression in rats and chickens (Veenema et al, 2010;Xie, Kuenzel, Anthony, & Jurkevich, 2010) and that enhanced c-Fos expression in this structure as well as the medial amygdala is linked to play fighting in juveniles (Cheng, Taravosh-Lahn, & Delville, 2008). These conflicting findings may stem from the fact that specific subregions of the BNST may differentially regulate functioning of the HPA stress axis in relation to excitation or inhibition of the response and whether stress exposure is chronic or acute (Choi et al, 2007(Choi et al, , 2008.…”

Section: Substratessupporting

confidence: 74%

Basic emotional foundations of social dominance in relation to Panksepp's affective taxonomy

Westhuizen

Solms

2015

Neuropsychoanalysis

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Section: Substratessupporting

confidence: 74%

Basic emotional foundations of social dominance in relation to Panksepp's affective taxonomy

Westhuizen

Solms

2015

Neuropsychoanalysis

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“…Using c-Fos expression as a reporter of relative differences in neuronal activation (Kovács, 2008) it has been demonstrated that the dorsal striatum (Gordon et al, 2002; van Kerkhof et al, 2014), ventral striatum (Gordon et al, 2002; van Kerkhof et al, 2014), medial prefrontal cortex (mPFC) (Cheng et al, 2008; van Kerkhof et al, 2014), bed nucleus of the stria terminalis (BNST) (Cheng et al, 2008; van Kerkhof et al, 2014), and dorsal raphe (van Kerkhof et al, 2014) are involved in juvenile social play. Not surprisingly, several brain regions known to mediate motivation/reward are implicated in the regulation of social play, a behavior that is highly rewarding in young rats (Vanderschuren et al, 2016).…”

Section: 0 Introductionmentioning

confidence: 99%

Analysis of c-Fos induction in response to social interaction in male and female Fisher 344 rats

et al. 2017

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Sex differences in the expression of social behavior are typically apparent in adolescent and adult rats. While the neurobiology underlying juvenile social play behavior has been well characterized, less is known about discrete brain regions involved in adult responsiveness to a same sex peer. Furthermore, whether adult males and females differ in their responsiveness to a social interaction in terms of neuronal activation indexed via immediate early gene (IEG) expression remains to be determined. Thus, the present study was designed to identify key sites relevant to the processing of sensory stimuli (generally) or social stimuli (specifically) after brief exposure to a same-sex social partner by assessing IEG expression. Four-month-old male and female Fisher (F) 344 rats (N = 38; n = 5–8/group) were either left undisturbed in their home cage as controls (HCC), exposed to a testing context alone for 30 min (CXT), or were placed in the context for 20 min and then allowed to socially interact (SI) with a sex-matched conspecific for 10 min. Females demonstrated greater levels of social behavior, relative to males. Analysis of c-Fos induction revealed that females exhibited greater c-Fos expression in the prefrontal cortex, regardless of condition. In many brain regions, induction was similar in the CXT and SI groups. However, in the bed nucleus of the stria terminalis (BNST), females exhibited greater c-Fos induction in response to the social interaction relative to their male counterparts, indicating a sex difference in responsivity to social stimuli. Taken together, these data suggest that the BNST is a sexually dimorphic region in terms of activation in response to social stimuli.

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“…Using c-fos as an activity marker, enhanced neuronal activity has been observed after social play behavior in several medial PFC regions, ie, anterior cingulate, prelimbic cortex (PrL) and infralimbic cortex (IL), as well as in orbitofrontal cortex (OFC) regions (Cheng et al, 2008;Gordon et al, 2002;Van Kerkhof et al, 2013). In keeping with these findings, the structure of social play and its sensitivity to social cues was found to be altered after neonatal lesions of the PFC or OFC (Bell et al, 2009;Panksepp et al, 1994;Pellis et al, 2006;Schneider and Koch, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, this somewhat resembles the effect of neonatal lesions of the medial PFC (Bell et al, 2009), suggesting involvement of projections from medial PFC to striatum in social play behavior. Further evidence for an involvement of corticostriatal projections is provided by immediate early gene expression studies, demonstrating that social play behavior induces c-fos expression in the striatum (Cheng et al, 2008;Gordon et al, 2002;Van Kerkhof et al, 2013). Interestingly, the levels of c-fos induced in medial PFC regions were found to correlate with the levels of c-fos in their striatal projection areas, suggesting that these projections are involved in social play behavior (Van Kerkhof et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…However, most of these studies used either indirect approaches (Cheng et al, 2008;Gordon et al, 2002;Van Kerkhof et al, 2013) or neonatal lesions (Bell et al, 2009;Panksepp et al, 1994;Pellis et al, 1993Pellis et al, , 2006Schneider and Koch, 2005), which may disrupt normal brain development and/or lead to compensatory changes in non-affected structures. Therefore, here we investigated the role of PFC and striatum subregions in social play behavior using a temporary pharmacological inactivation technique, which allows for transient disruption of functional activity but leaves normal brain development and function intact (Martin, 1991;McFarland and Kalivas, 2001;Van Duuren et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Social Play Behavior in Adolescent Rats is Mediated by Functional Activity in Medial Prefrontal Cortex and Striatum

Kerkhof

Damsteegt

Trezza

et al. 2013

Neuropsychopharmacol

136

118

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Social play behavior is a characteristic, vigorous form of social interaction in young mammals. It is highly rewarding and thought to be of major importance for social and cognitive development. The neural substrates of social play are incompletely understood, but there is evidence to support a role for the prefrontal cortex (PFC) and striatum in this behavior. Using pharmacological inactivation methods, ie, infusions of GABA receptor agonists (baclofen and muscimol; B&M) or the AMPA/kainate receptor antagonist 6,7-dinitroquinoxaline-2,3(1H,4H)-dione (DNQX), we investigated the involvement of several subregions of the medial PFC and striatum in social play. Inactivation of the prelimbic cortex, infralimbic cortex, and medial/ventral orbitofrontal cortex using B&M markedly reduced frequency and duration of social play behavior. Local administration of DNQX into the dorsomedial striatum increased the frequency and duration of social play, whereas infusion of B&M tended to have the same effect. Inactivation of the nucleus accumbens (NAcc) core using B&M increased duration but not frequency of social play, whereas B&M infusion into the NAcc shell did not influence social play behavior. Thus, functional integrity of the medial PFC is important for the expression of social play behavior. Glutamatergic inputs into the dorsomedial striatum exert an inhibitory influence on social play, and functional activity in the NAcc core acts to limit the length of playful interactions. These results highlight the importance of prefrontal and striatal circuits implicated in cognitive control, decision making, behavioral inhibition, and reward-associated processes in social play behavior.

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Neural circuitry of play fighting in golden hamsters

Cited by 49 publications

References 61 publications

Basic emotional foundations of social dominance in relation to Panksepp's affective taxonomy

Basic emotional foundations of social dominance in relation to Panksepp's affective taxonomy

Analysis of c-Fos induction in response to social interaction in male and female Fisher 344 rats

Social Play Behavior in Adolescent Rats is Mediated by Functional Activity in Medial Prefrontal Cortex and Striatum

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