Neural circuit control of innate behaviors

Xiao, Wei; Jiao, Zhuo-Lei; Senol, Esra; Yao, Jiwei; Zhao, Miao; Zhao, Zhengdong; Chen, Xiaowei; Cao, Peng; Fu, Yang Ming; Gao, Zhihua; Shen, Wei; Xu, Xiaohong

doi:10.1007/s11427-021-2043-2

Cited by 17 publications

(13 citation statements)

References 395 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In patients with UD, the lesions were mostly located in the dorsolateral pons including the LC, reticular formation, and pontine reticular nucleus, which were comparable to the PMC sites in animal experiments ( Sakakibara et al, 1996b ). Owing to the advancement in neuroimaging, functional MRI and positron emission tomography (PET) have allowed us to evaluate roles of the prefrontal cortex, anterior cingulate cortex, insula, hypothalamus, parahippocampal complex, supplementary motor area, PAG, and PMC in human bladder management ( Griffiths, 2015 ; Xiao et al, 2022 ). One study using cranial PET for 44 patients showed that the right hemisphere, including the anterior cingulate cortex, parts of the premotor cortex, putamen, claustrum, and insula, plays an important role in patients with frontotemporal lobe degeneration and urinary incontinence ( Perneczky et al, 2008 ).…”

Section: Etiology and Pathologymentioning

confidence: 99%

“…The hypothalamus efferent projections go directly to the PMC, bypass the PAG, to send signals saying that it is safe or unsafe to void ( Griffiths, 2015 ). Neural circuits joining the cortex to the lumbosacral spinal cord and to the bladder and urethra must remain intact for adults to urinate under suitable conditions ( Xiao et al, 2022 ). These networks are shown in Figure 2 .…”

Section: Etiology and Pathologymentioning

confidence: 99%

See 1 more Smart Citation

Urinary dysfunction in patients with vascular cognitive impairment

Zhao

Zhang²,

Shen³

et al. 2023

Front. Aging Neurosci.

View full text Add to dashboard Cite

Vascular cognitive impairment (VCI) is caused by vascular pathologies, with the spectrum of cognitive disorders ranging from subjective cognitive dysfunction to dementia. Particularly among older adults, cognitive impairment is often complicated with urinary dysfunction (UD); some patients may present with UD before cognitive impairment owing to stroke or even when there are white matter hyperintensities on imaging studies. Patients with cognitive impairment often have both language and movement dysfunction, and thus, UD in patients with VCI can often be underdiagnosed and remain untreated. UD has an impact on the quality of life of patients and caregivers, often leading to poor outcomes. Medical history is an important aspect and should be taken from both patients and their caregivers. Clinical assessment including urinalysis, voiding diary, scales on UD and cognitive impairment, post-void residual volume measurement, uroflowmetry, and (video-) urodynamics should be performed according to indication. Although studies on UD with VCI are few, most of them show that an overactive bladder (OAB) is the most common UD type, and urinary incontinence is the most common symptom. Normal urine storage and micturition in a specific environment are complex processes that require a sophisticated neural network. Although there are many studies on the brain–urinary circuit, the specific circuit involving VCI and UD remains unclear. Currently, there is no disease-modifying pharmacological treatment for cognitive impairment, and anti-acetylcholine drugs, which are commonly used to treat OAB, may cause cognitive impairment, leading to a vicious circle. Therefore, it is important to understand the complex interaction between UD and VCI and formulate individualized treatment plans. This review provides an overview of research advances in clinical features, imaging and pathological characteristics, and treatment options of UD in patients with VCI to increase subject awareness, facilitate research, and improve diagnosis and treatment rates.

show abstract

Section: Etiology and Pathologymentioning

confidence: 99%

Section: Etiology and Pathologymentioning

confidence: 99%

Urinary dysfunction in patients with vascular cognitive impairment

Zhao

Zhang²,

Shen³

et al. 2023

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Animals display a series of innate and goal-directed behaviors that are critical for survival and reproduction at both the individual and species levels, such as feeding, courting, and fighting [ 1 ]. Each behavior is characterized by its own complex action patterns, modulated by multiple sensory inputs, and executed typically in a mutually exclusive manner [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Most importantly, the neural circuits underlying individual innate behaviors, including sex, aggression, feeding, and sleep, have been well elucidated in recent years, making Drosophila an ideal model in which to study the mechanisms of decision-making among innate behaviors. Neural circuit mechanisms underlying individual innate behaviors have also been intensively studied in mice, with huge progress in the last two decades [ 1 , 13 – 18 ]. Here, we review some of the latest progress on the neural circuits and neuromodulatory mechanisms of interaction among sex, fight, feeding, and sleep in both sexes of Drosophila , and compare the circuit configurations in flies and mice, aiming to provide new insights for understanding the neural mechanisms of action selection.…”

Section: Introductionmentioning

confidence: 99%

Neural Control of Action Selection Among Innate Behaviors

Jiang

Pan

2022

Neurosci. Bull.

View full text Add to dashboard Cite

Nervous systems must not only generate specific adaptive behaviors, such as reproduction, aggression, feeding, and sleep, but also select a single behavior for execution at any given time, depending on both internal states and external environmental conditions. Despite their tremendous biological importance, the neural mechanisms of action selection remain poorly understood. In the past decade, studies in the model animal Drosophila melanogaster have demonstrated valuable neural mechanisms underlying action selection of innate behaviors. In this review, we summarize circuit mechanisms with a particular focus on a small number of sexually dimorphic neurons in controlling action selection among sex, fight, feeding, and sleep behaviors in both sexes of flies. We also discuss potentially conserved circuit configurations and neuromodulation of action selection in both the fly and mouse models, aiming to provide insights into action selection and the sexually dimorphic prioritization of innate behaviors.

show abstract

“…Urine storage and elimination are two major physiological functions of the bladder, which are controlled by complex neural circuits distributed throughout the brain, spinal cord, and peripheral nerves (Fowler et al, 2008 ; Xiao et al, 2022 ). However, abnormalities and lesions at any level of this control system can lead to neurogenic lower urinary tract symptoms (LUTS; Benarroch, 2010 ; Tish and Geerling, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Ventrolateral Periaqueductal Gray Neurons Are Active During Urination

Rao

Gao²,

Li³

et al. 2022

Front. Cell. Neurosci.

Self Cite

View full text Add to dashboard Cite

The ventrolateral periaqueductal gray (VLPAG) is thought to be the main PAG column for bladder control. PAG neurons (especially VLPAG neurons) and neurons in the pontine micturition center (PMC) innervating the bladder detrusor have anatomical and functional synaptic connections. The prevailing viewpoint on neural control of the bladder is that PAG neurons receive information on the decision to void made by upstream brain regions, and consequently activate the PMC through their direct projections to initiate urination reflex. However, the exact location of the PMC-projecting VLPAG neurons, their activity in response to urination, and their whole-brain inputs remain unclear. Here, we identified the distribution of VLPAG neurons that may participate in control of the bladder or project to the PMC through retrograde neural tracing. Population Ca2+ signals of PMC-projecting VLPAG neurons highly correlated with bladder contractions and urination as shown by in vivo recording in freely moving animals. Using a RV-based retrograde trans-synaptic tracing strategy, morphological results showed that urination-related PMC-projecting VLPAG neurons received dense inputs from multiple urination-related higher brain areas, such as the medial preoptic area, medial prefrontal cortex, and lateral hypothalamus. Thus, our findings reveal a novel insight into the VLPAG for control of bladder function and provide a potential therapeutic midbrain node for neurogenic bladder dysfunction.

show abstract

Neural circuit control of innate behaviors

Cited by 17 publications

References 395 publications

Urinary dysfunction in patients with vascular cognitive impairment

Urinary dysfunction in patients with vascular cognitive impairment

Neural Control of Action Selection Among Innate Behaviors

Ventrolateral Periaqueductal Gray Neurons Are Active During Urination

Contact Info

Product

Resources

About