Neural basis of hunger-driven behaviour in
            <i>Drosophila</i>

Lin, Suewei; Senapati, Bhagyashree; Tsao, Chang-Hui

doi:10.1098/rsob.180259

Cited by 99 publications

(119 citation statements)

References 115 publications

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“…et al, 2008). These findings are indeed contradictory to the proposed role of sNPF as a hunger signal in Drosophila, however, up-regulation of DILP genes by sNPF might relate more to regulating metabolism and growth, rather than feeding (Lin et al, 2019).…”

Section: Short Neuropeptide F (Snpf) and Neuropeptide F (Npf)contrasting

confidence: 82%

The Role of Peptide Hormones in Insect Lipid Metabolism

Toprak

2020

Front. Physiol.

100

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Lipids are the primary storage molecules and an essential source of energy in insects during reproduction, prolonged periods of flight, starvation, and diapause. The coordination center for insect lipid metabolism is the fat body, which is analogous to the vertebrate adipose tissue and liver. The fat body is primarily composed of adipocytes, which accumulate triacylglycerols in intracellular lipid droplets. Genomics and proteomics, together with functional analyses, such as RNA interference and CRISPR/Cas9-targeted genome editing, identified various genes involved in lipid metabolism and elucidated their functions. However, the endocrine control of insect lipid metabolism, in particular the roles of peptide hormones in lipogenesis and lipolysis are relatively less-known topics. In the current review, the neuropeptides that directly or indirectly affect insect lipid metabolism are introduced. The primary lipolytic and lipogenic peptide hormones are adipokinetic hormone and the brain insulinlike peptides (ILP2, ILP3, ILP5). Other neuropeptides, such as insulin-growth factor ILP6, neuropeptide F, allatostatin-A, corazonin, leucokinin, tachykinins and limostatin, might stimulate lipolysis, while diapause hormone-pheromone biosynthesis activating neuropeptide, short neuropeptide F, CCHamide-2, and the cytokines Unpaired 1 and Unpaired 2 might induce lipogenesis. Most of these peptides interact with one another, but mostly with insulin signaling, and therefore affect lipid metabolism indirectly. Peptide hormones are also involved in lipid metabolism during reproduction, flight, diapause, starvation, infections and immunity; these are also highlighted. The review concludes with a discussion of the potential of lipid metabolism-related peptide hormones in pest management.

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Section: Short Neuropeptide F (Snpf) and Neuropeptide F (Npf)contrasting

confidence: 82%

The Role of Peptide Hormones in Insect Lipid Metabolism

Toprak

2020

Front. Physiol.

100

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“…As AKH co-activates with insulin-like peptides to regulate glucose and lipid metabolism [48], we infer that AKH adjusts the dynamic balance of glucose levels in sensory Gr5a neurons. In fruit flies, memory can be reinforced up to several days when specific odors are paired with glucose [49]. We believe that the memory system required for SMD is interrupted and the male flies are no longer primed for this behaviour.…”

Section: Discussionmentioning

confidence: 94%

Neuropeptide relay between SIFa signaling controls the experience-dependent mating duration of male Drosophila

Wong

Schweizer

Nguyen

et al. 2019

Preprint

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Drosophila melanogaster is a suitable model for investigating how neuropeptides influence animal behaviours and physiology. We previously reported that two behavioural paradigms control mating duration of male Drosophila, called Longer-Mating-Duration (LMD) andShorter-Mating-Duration (SMD) that are induced through socio-sexual environment prior to copulation. Understanding the molecular and cellular mechanisms by which males exhibit plasticity to different social cues remains poorly understood. Here, we show that SIFa modulates the neural circuitry for both LMD and SMD. Neuropeptide-to-neuropeptide communication, so called 'neuropeptide relay' plays a key role to mediate this control. We identified that 7 neuropeptides expressed in SIFa Receptor-positive cells are functionally important to regulate either LMD and/or SMD. The modulation of two independent mating duration behaviour by the different SIFa-mediated neuropeptide relay will help to further investigate how the neuropeptidergic modulation can control complex behaviours.

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“…Drosophila behaviors are also regulated by internal motivational states and the relatively small brain and genetic tractability of the fruit fly make it possible to discover the underlying neural circuit mechanisms. Starvation in flies has been linked to release of a wide variety of neuromodulators, that in turn promote eating and food-seeking behavior by modulating peripheral and central neuronal circuits 3 . Interaction between hunger and thirst motivational systems has also been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

A neural mechanism for deprivation state-specific expression of relevant memories in Drosophila

et al. 2019

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Motivational states modulate how animals value sensory stimuli and engage in goal-directed behaviors. The motivational states of thirst and hunger are represented in the brain by shared and unique neuromodulatory systems. However, it is unclear how such systems interact to coordinate expression of appropriate state-specific behavior. We show that the activity of two brain neurons expressing leucokinin (LK) neuropeptide is elevated in thirsty and hungry flies, and that LK release is necessary for state-dependent expression of water and sugar-seeking memories. LK inhibits two types of mushroom body (MB)-innervating dopaminergic neurons (DANs) to promote thirst-specific water-memory expression, whereas it activates other MB-innervating DANs to facilitate hunger-dependent sugar-memory expression. Selection of hunger-or thirst-appropriate memory emerges from competition between LK and other neuromodulatory hunger signals at the level of the DANs. Therefore, coordinated modulation of the dopaminergic system allows flies to prioritize the expression of the relevant state-dependent motivated behavior. Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:

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Neural basis of hunger-driven behaviour in Drosophila

Cited by 99 publications

References 115 publications

The Role of Peptide Hormones in Insect Lipid Metabolism

The Role of Peptide Hormones in Insect Lipid Metabolism

Neuropeptide relay between SIFa signaling controls the experience-dependent mating duration of male Drosophila

A neural mechanism for deprivation state-specific expression of relevant memories in Drosophila

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