Neuropeptide relay between SIFa signaling controls the experience-dependent mating duration of male <i>Drosophila</i>

Wong, Kyle; Schweizer, Justine; Nguyen, Khoi-Nguyen Ha; Atieh, Shatha; Kim, Woo Jae

doi:10.1101/819045

Cited by 6 publications

(12 citation statements)

References 48 publications

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“…S12B-C). Consistent with our previous report on the different neural circuitry for LMD and SMD [59], these data clearly show that male flies use different sensory modalities to generate LMD or SMD, respectively.…”

Section: Discussionsupporting

confidence: 92%

Multisensory inputs control the regulation of time investment for mating by sexual experience in male Drosophila melanogaster

Kim

Lee

Kang

et al. 2022

Preprint

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Males have finite resources to spend on reproduction. Thus, males rely on a 'time investment strategy' to maximize their reproductive success. For example, male Drosophila melanogaster extends their mating duration when surrounded by conditions enriched with rivals. Here we report a novel form of behavioral plasticity whereby male fruit flies exhibit a shortened duration of mating when they are sexually experienced; we refer to this plasticity as 'shorter-mating-duration (SMD)'. SMD is a plastic behavior and requires sexually dimorphic taste neurons. We identified several neurons in the male foreleg and midleg that express specific sugar, pheromone and mechanosensory receptors. Using a cost-benefit model and behavioral experiments, we further show that SMD behavior exhibits adaptive behavioral plasticity in male flies. Thus, our study delineates the molecular and cellular basis of the sensory inputs required for SMD; this represents a plastic interval timing behavior that could serve as a model system to study how multisensory inputs converge to modify interval timing behavior for improved adaptation.

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Section: Discussionsupporting

confidence: 92%

Multisensory inputs control the regulation of time investment for mating by sexual experience in male Drosophila melanogaster

Kim

Lee

Kang

et al. 2022

Preprint

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“…S6E). The modulation of interval timing in LMD is primarily facilitated through the visual pathway 36,37,46 S6C, D). However, this percentage increased to 30% in the AG region (Fig.…”

Section: Enhancementmentioning

confidence: 99%

Long-range neuropeptide relay as a central-peripheral communication mechanism for the context-dependent modulation of interval timing behaviors

Zhang,

Wu,

Song

et al. 2024

Preprint

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Neuropeptides play crucial roles in regulating context-dependent behaviors, but the underlying mechanisms remain elusive. We investigate the role of the neuropeptide SIFa and its receptor SIFaR in regulating two distinct mating duration behaviors in maleDrosophila: Longer-Mating-Duration (LMD) and Shorter-Mating-Duration (SMD). We found that SIFaR expression in specific neurons is required for both LMD and SMD behaviors. Social context and sexual experience lead to synaptic reorganization between SIFa and SIFaR neurons, altering internal states of brain. We revealed that the SIFa-SIFaR/Crz-CrzR neuropeptide relay pathway is essential for generating distinct interval timing behaviors, with Crz neurons being responsive to the activity of SIFa neurons. Additionally, CrzR expression in non-neuronal cells is critical for regulating LMD and SMD behaviors. Our study provides insights into how neuropeptides and their receptors modulate context-dependent behaviors through synaptic plasticity and calcium signaling, with implications for understanding the neural circuitry underlying interval timing and neuropeptidergic system modulation of behavioral adaptations.

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“…Nevertheless, the MP1/MP3 neurons appear to be involved in the switching between conflicting behaviors, probably by integrating different types of inputs that relay information about the external and internal environment. Other similar peptidergic brain systems are constituted for example by the four widely arborizing SIFamide-producing neurons that integrate sexual behavior, feeding and sleep by interactions with multiple brain and VNC circuits [ 237 , 267 , 281 , 282 ] and Hugin neurons that integrate homeostatic sleep signals and the circadian clock, and relays locomotor activity output in adults [ 283 , 284 ]. In larvae, Hugin neurons receive gustatory inputs and form a hub between feeding and locomotion [ 251 , 285 ], a function that is not yet explored in adult flies.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Cholecystokinin/sulfakinin peptide signaling: conserved roles at the intersection between feeding, mating and aggression

Nässel

2022

Cell. Mol. Life Sci.

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Neuropeptides are the most diverse messenger molecules in metazoans and are involved in regulation of daily physiology and a wide array of behaviors. Some neuropeptides and their cognate receptors are structurally and functionally well conserved over evolution in bilaterian animals. Among these are peptides related to gastrin and cholecystokinin (CCK). In mammals, CCK is produced by intestinal endocrine cells and brain neurons, and regulates gall bladder contractions, pancreatic enzyme secretion, gut functions, satiety and food intake. Additionally, CCK plays important roles in neuromodulation in several brain circuits that regulate reward, anxiety, aggression and sexual behavior. In invertebrates, CCK-type peptides (sulfakinins, SKs) are, with a few exceptions, produced by brain neurons only. Common among invertebrates is that SKs mediate satiety and regulate food ingestion by a variety of mechanisms. Also regulation of secretion of digestive enzymes has been reported. Studies of the genetically tractable fly Drosophila have advanced our understanding of SK signaling mechanisms in regulation of satiety and feeding, but also in gustatory sensitivity, locomotor activity, aggression and reproductive behavior. A set of eight SK-expressing brain neurons plays important roles in regulation of these competing behaviors. In males, they integrate internal state and external stimuli to diminish sex drive and increase aggression. The same neurons also diminish sugar gustation, induce satiety and reduce feeding. Although several functional roles of CCK/SK signaling appear conserved between Drosophila and mammals, available data suggest that the underlying mechanisms differ.

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Neuropeptide relay between SIFa signaling controls the experience-dependent mating duration of male Drosophila

Cited by 6 publications

References 48 publications

Multisensory inputs control the regulation of time investment for mating by sexual experience in male Drosophila melanogaster

Multisensory inputs control the regulation of time investment for mating by sexual experience in male Drosophila melanogaster

Long-range neuropeptide relay as a central-peripheral communication mechanism for the context-dependent modulation of interval timing behaviors

Cholecystokinin/sulfakinin peptide signaling: conserved roles at the intersection between feeding, mating and aggression

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