Neural and neurovascular connections between the hypothalamic neurosecretory center and the adenohypophysis

Ultrastructural Changes of the Pars Tuberalis and Median Eminence of Rats Following Hypophysectomy

“…Recently; several authors observed in mammals that neurosecretory axons with large cored vesicles were also present in the external layer of the median eminence (KNOWLES, 1967;BERGLAND and TORACK, 1969). These findings are in agreement with earlier histological findings after Gomori staining (ARKO and KIVALO, 1958;OKAMOTO and IHARA, 1960;RINNE, 1960;DAIKOKU et al, 1967).…”

Light-Microscopic Studies on the Development of the Interrelationship Between the Neurosecretory Pathway and the Portal System in Rats

“…In mammals several authors observed that the capillary loops make contact with neurosecretory fibers in the intermediate layer of the median eminence (Scharrer and Scharrer, 1954 a and b;Scharrer, 1956). Okamoto and Ihara (1960) proposed that the neurosecretory fibers in the median eminence penetrate into the pars tuberalis of the pituitary, and that this extension exists not only in mammals but also in birds and frogs. Arizono and Okamoto (1957) showed that the neurosecretory substance was carried by neurosecretory fibers branching from the hypothalamo-hypophysial tract and terminating at the wall of the portal vessels.…”