Neural activity in functional movement disorders after inpatient rehabilitation

Faul, Leonard; Knight, Lindsay K.; Espay, Alberto J.; Depue, Brendan E.; LaFaver, Kathrin

doi:10.1016/j.pscychresns.2020.111125

Cited by 20 publications

(34 citation statements)

References 44 publications

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“…These findings, particularly heightened amygdala-motor control circuit coupling, may represent markers of heightened limbic influence over motor behavior ( Voon et al, 2010a ). Preliminary data also suggest that baseline increased task-related corticolimbic activity may predict treatment responses to cognitive behavioral therapy (CBT) and short-term inpatient multidisciplinary motor retraining ( Espay et al, 2019 , Faul et al, 2020 ).…”

Section: Fnd Neural Circuitry - a Synopsismentioning

confidence: 99%

“…In terms of state (patients with active symptoms) vs. trait (patient-specific characteristics in those without current symptoms ), within-group longitudinal designs can be informative. Some studies used patients as their own controls, with and without symptoms ( Vuilleumier et al, 2001 ) or before and after treatment ( Espay et al, 2019 , Faul et al, 2020 ). An advantage of within-subject designs are their enhanced statistical power.…”

Section: Control Group Considerationsmentioning

confidence: 99%

“…Basic motor performance (e.g., finger tapping) tasks have also been used in FND-movt populations ( Espay et al, 2018b , Espay et al, 2018c , Schrag et al, 2013 ). Recent studies have investigated the interplay between motor control and emotion processing using paradigms such as an emotional Go/No-Go ( Faul et al, 2020 , Hassa et al, 2017 ); in another study, participants were asked to maintain grip strength while viewing affectively-valenced images ( Blakemore et al, 2016 ).…”

Section: Task-based Neuroimagingmentioning

confidence: 99%

See 2 more Smart Citations

Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda

Perez

Nicholson

Asadi-Pooya

et al. 2021

NeuroImage: Clinical

102

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Highlights 1st Neuroimaging Workgroup Meeting in Functional Neurological Disorder (FND). Underscores the importance of FND cohort characterization in brain imaging research. Details methodological approaches taken in FND neuroimaging research to date. Research agenda proposed to definitely elucidate the neural circuitry of FND. Discussions underway regarding having FND researchers join the ENIGMA consortium.

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Section: Fnd Neural Circuitry - a Synopsismentioning

confidence: 99%

Section: Control Group Considerationsmentioning

confidence: 99%

Section: Task-based Neuroimagingmentioning

confidence: 99%

See 1 more Smart Citation

Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda

Perez

Nicholson

Asadi-Pooya

et al. 2021

NeuroImage: Clinical

102

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“…The midbrain, as the re ex center of vision and hearing, participates in the information feedback link of the closed-loop control system and can modify an executing movement in time. This is part of the typical theory of motion control [15] .The cerebellar vermis(including cerebellar lingual) belongs to the anterior cerebellum and plays an important role in the transmission and feedback of the brain-cerebellar sensorimotor network [16,17] .The mammillary body related to the operation of emotions is a part of the limbic system of the brain. According to some literatures [18] , erce emotions can affect the control of movement and produce signi cant behavioral responses to posture patterns or motor strategies.…”

Section: Normal Group (Hs) Vs Dominant Hemisphere Group (Dh)mentioning

confidence: 99%

Hemispheric difference of regional brain function exists in patients with acute stroke in different cerebral hemispheres：a resting-state fMRI study

Gao

Yang

et al. 2020

Preprint

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Objective: To explore the different compensatory mechanisms of brain function between the patients with brain dysfunction after acute ischemic stroke (AIS) in dominant hemisphere and the non-dominant hemisphere, based on Resting-state Functional Magnetic Resonance Imaging (Rs-fMRI).Methods: In this trial, 15 healthy subjects(HS) were used as blank controls. 30 hemiplegic patients with middle cerebral artery acute infarction of the different dominant hemisphere were divided into the dominant hemisphere group (DH) and the non-dominant hemisphere group (NDH), scanned by a 3.0 T MRI scanner, to obtain the amplitude of low frequency fluctuations (ALFF) and regional homogeneity (ReHo) and compare the differences.Results: Compared with the HS, increased ALFF values in the brain areas such as bilateral midbrain were observed in DH. While decreased ReHo values in the brain areas such as right postcentral gyrus (BA3) were also observed. Enhanced ALFF values in the brain areas such as left BA6, and enhanced ReHo values in the brain areas such as left precuneus were observed in NDH. And the ALFF and ReHo values of right BA9 and precentral gyrus were both increased. Compared with DH, NDH have lower ALFF values in left supplementary motor area and lower ReHo values in right BA10.Conclusion: After acute infarction in the middle cerebral artery of the dominant hemisphere, a compensation mechanism is triggered in brain areas of the ipsilateral cortex regulating motor-related pathways, while some brain areas related to cognition, sensation and motor in the contralateral cortex are suppressed, and the connection with the peripheral brain regions is weakened. After acute infarction in the middle cerebral artery of the non-dominant hemisphere, compensatory activation appears in motor control-related brain areas of the dominant hemisphere. After acute middle cerebral artery infarction in the dominant hemisphere, compared with the non-dominant hemisphere, functional specificity in bilateral supplementary motor area weakens. After acute middle cerebral artery infarction in different hemispheres, there are hemispheric differences in the compensatory mechanism of brain function. Trial registration: Ethics Committee of the China-Japan Union Hospital at Jilin University approval. Trial Registration Number:Chinese Clinical Trial Registry ChiCTR-IOR-15007672. Registered July 18, 2016 (No. 2016ks043).

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“…The copyright holder for this preprint this version posted February 3, 2021. ; https://doi.org/10.1101/2021.02.01.21250621 doi: medRxiv preprint functional motor symptoms is associated with changes in brain regions and networks implicated in FMD (11,12).…”

Section: Introductionmentioning

confidence: 99%

Targeting fronto-limbic dysfunctions via intermittent theta burst stimulation as a novel treatment for Functional Movement Disorders

Parker

Horovitz

et al. 2021

Preprint

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Background. Neuroimaging studies suggest that corticolimbic dysfunctions, including increased amygdala reactivity to emotional stimuli and heightened fronto-amygdala coupling, play a central role in the pathophysiology of functional movement disorders (FMD), although there is no direct causal evidence of this relationship. Transcranial magnetic stimulation (TMS) has the potential to probe and modulate brain networks implicated in neuropsychiatric disorders, including FMD. Therefore, in this proof-of-concept study, we investigated safety, tolerability and preliminary efficacy of fronto-amygdala neuromodulation via targeted left prefrontal intermittent theta burst stimulation (iTBS) on brain and behavioral manifestations of FMD. Methods. Six subjects with a clinically defined diagnosis of FMD received three open-label iTBS sessions per day, for two consecutive study visits. Safety and tolerability were assessed throughout the trial. Amygdala reactivity to emotionally valenced stimuli presented during an fMRI task and fronto-amygdala connectivity at rest were evaluated at baseline and after each stimulation visit, together with subjective levels of arousal and valence in response to affective stimuli. FMD symptom severity was assessed at baseline, during treatment and 24 hours after receiving the last iTBS session. Results. Multiples doses of iTBS were well-tolerated by all participants. Intermittent TBS significantly decreased fronto-amygdala connectivity and also influenced amygdala reactivity to emotional stimuli. These neurocircuitry changes were associated to a significant decrease in negative valence and an increase in positive valence levels following iTBS. Furthermore, we also observed a marked reduction in FMD symptom severity post stimulation. Conclusions. Corticolimbic modulation via iTBS represents a promising treatment for FMD that warrants additional research.

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Neural activity in functional movement disorders after inpatient rehabilitation

Cited by 20 publications

References 44 publications

Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda

Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda

Hemispheric difference of regional brain function exists in patients with acute stroke in different cerebral hemispheres：a resting-state fMRI study

Targeting fronto-limbic dysfunctions via intermittent theta burst stimulation as a novel treatment for Functional Movement Disorders

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