Neumonitis por hipersensibilidad asociada a tramadol

López-Marina, V.; Pizarro-Romero, Gregorio; Costa-Bardaji, Natalia

doi:10.1157/13083574

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…Of the six most serious cases involving the oral cavity, pharynx and/or upper respiratory tract, four patients needed emergency treatment and two of these treatments were in the intensive care unit 138 . Apart from possible IgE antibodymediated responses, other induced or suspected hypersensitivities to the drug include hypersensitivity pneumonitis 139 , a maculopapular toxic skin reaction 140 and possible cases of Stevens-Johnson and Lyell's syndromes, although causal associations were in doubt for the syndromes 141 .…”

Section: Synthetic Opioid Drugsmentioning

confidence: 99%

Histamine-Releasing and Allergenic Properties of Opioid Analgesic Drugs: Resolving the Two

Baldo¹,

Pham²

2012

Anaesth Intensive Care

136

105

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Opioid analgesics are amongst the most commonly administered drugs in hospitals. Whether natural or synthetic, they show some common structural features, morphine-like pharmacological action and binding specificity for complementary opioid receptors. Tramadol differs from the other opioid analgesics in possessing monoaminergic activity in addition to its affinity for the μ opioid receptor. Many opioids are potent histamine releasers producing a variety of haemodynamic changes and anaphylactoid reactions, but the relationship of the appearance of these effects to the histamine plasma concentration is complex and there is no direct and invariable relationship between the two. Studies of the histamine-releasing effects, chiefly centred on morphine, reveal variable findings and conclusions often due to a range of factors including differences in technical measurements, dose, mode of administration, site of injection, the anatomical distribution of histamine receptors and heterogeneity of patient responses. Morphine itself has multiple direct effects on the vasculature and other haemodynamically-active mediators released along with histamine contribute to the variable responses to opioid drug administration. Despite their heavy use and occasional apparent anaphylactic-like side-effects, immunoglobulin E antibodymediated immediate hypersensitivity reactions to the drugs are not often encountered. uncertainties associated with skin testing with these known histamine-releasers, and the general unavailability of opioid drug-specific immunoglobulin E antibody tests contribute to the frequent failure to adequately investigate and establish underlying mechanisms of reactions by distinguishing anaphylactoid from true anaphylactic reactions. Clinical implications for diagnosis of reactions and some speculations on the rarity of true Type 1 allergies to these drugs are presented.

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Section: Synthetic Opioid Drugsmentioning

confidence: 99%

Histamine-Releasing and Allergenic Properties of Opioid Analgesic Drugs: Resolving the Two

Baldo¹,

Pham²

2012

Anaesth Intensive Care

136

105

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“…En un reporte de caso de Mori et al, se presenta un paciente con asma alérgica que, luego de recibir tramadol, desarolló anafilaxia e insuficiencia respiratoria, requiriendo de intubación, manejo con corticoesteroide y epinefrina (9) . Hay reportes de reacción tipo I mediada por IgE relacionadas con tramadol (5,28) . En Hallberg et al, se hace un reporte de seis casos de angioedema inducido por tramadol (10) .…”

Section: Discussionunclassified

Anaflaxia a opioides en un paciente oncológico pediátrico: reporte de caso

Medina

2020

revista de salud udh

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Se presenta el caso de un paciente de 5 años con diagnóstico de leucemia linfoblástica aguda y trisomía 21, quien fue hospitalizado para manejo con quimioterapia de primera línea en quien se presentaron diversascomplicaciones durante su tratamiento, por lo que requirió manejo antibiótico y analgésico opioide. Posteriormente, desarrolla cuatro reacciones alérgicas; tres de ellas asociadas a opioides y una catalogada como angioedema severo relacionado con tramadol. Se presenta el caso clínico debido a la baja incidenciade reacciones severas alérgicas a opioides, particularmente al tramadol en el contexto de pacientes de alta complejidad con polimedicación.

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“…In addition to possible IgE antibody-mediated responses, other delayed hypersensitivities to the drug include hypersensitivity pneumonitis [15] , a maculopapular toxic skin reaction [16] , and uncertain cases of Stevens-Johnson and Lyell's syndromes [17] . This is the first case of anaphylaxis to tramadol in a child that has been described thus far.…”

Section: Discussionmentioning

confidence: 99%

Anaphylaxis to Intravenous Tramadol in a Child

Mori

Barni²,

Manfredi³

et al. 2015

Pharmacology

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Hypersensitivity reactions to tramadol are rare and the drug is commonly considered safe. Here, we report the first case of anaphylaxis to tramadol in a child. We point out the difficulty in reaching a confident diagnosis when testing opioid alkaloid drugs with histamine-releasing properties. Additionally, we showed the importance of a well-performed allergy work-up, especially when testing drugs with low experience and when standardized concentrations have not been tested. Moreover, this case provides insight into the possibility of severe reactions, and even anaphylaxis, to tramadol.

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Neumonitis por hipersensibilidad asociada a tramadol

Cited by 6 publications

References 9 publications

Histamine-Releasing and Allergenic Properties of Opioid Analgesic Drugs: Resolving the Two

Histamine-Releasing and Allergenic Properties of Opioid Analgesic Drugs: Resolving the Two

Anaflaxia a opioides en un paciente oncológico pediátrico: reporte de caso

Anaphylaxis to Intravenous Tramadol in a Child

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