Neuere Ergebnisse der Calciumforschung

Klinke, K.

doi:10.1007/bf02749139

Cited by 102 publications

(4 citation statements)

References 145 publications

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“…We have shown that bile and bile acids increase the solubility and the absorption of calcium presented as the sparingly soluble calcium hydrogen phosphate (Tables 18 and 19), and this is a further and direct effect of bile on calcium absorption. Such an effect of bile was suggested by Klinke (1928), who showed that sodium deoxycholate increased the solubility of calcium carbonate, phosphate and oleate. He postulated that calcium was absorbed as a complex with longchain fatty acids and bile salt.…”

Section: Discussionmentioning

confidence: 76%

“…However, irradiated ergosterol contains only vitamin D2, which is poorly antirachitic in birds. Klinke (1928) and later Verzar & McDougall (1936) suggested that calcium, fatty acids and bile acids together form a soluble 408 BILE ACIDS AND CALCIUM ABSORPTION diffusible complex in the intestine that could be absorbed readily as such and broken down within the body, liberating free calcium.…”

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confidence: 99%

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The effect of bile, bile acids and detergents on calcium absorption in the chick

Webling

Holdsworth

1965

Biochemical Journal

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1. Bile from rachitic or normal chicks causes an immediate increase in the intestinal absorption of soluble calcium in rachitic and vitamin D(3)-treated chicks as tested in vivo by intestinal-loop and oral-dosing methods. 2. This effect is apparently solely due to the taurine-conjugated bile acids present in the bile and is independent of the action of vitamin D. 3. Chick bile and bile acids can increase the solubility and the absorption of calcium presented as sparingly soluble calcium hydrogen phosphate. 4. In addition, bile is necessary to some extent at least for the intestinal absorption of vitamin D(3) in the chick and this would indirectly enhance the absorption of calcium. 5. Thus bile is capable of a threefold action in the absorption of calcium in the chick. It is suggested that the direct action on sparingly soluble forms of calcium is of considerable physiological importance since most of the calcium in the normal bird's diet would be in this form. 6. Bile acids enhance the absorption of calcium in all regions of the small intestine of the chick. 7. Of a range of bile acids and detergents tested for enhancement of calcium absorption, various taurine-conjugated bile acids and sodium lauryl sulphate, an anionic detergent, are effective. A non-ionic detergent (Tween 80) and a cationic detergent (Zephiran) are without effect. 8. The ability of a substance to increase directly the intestinal absorption of soluble calcium appears to depend to some extent on an anionic detergent action, i.e. the ability to form a salt or complex soluble to some extent in both aqueous and lipid phases. 9. In chicks the immediate deposition of calcium ((45)Ca) in the bones closely reflects any increase in plasma calcium radioactivity regardless of the cause of the increase and regardless of the vitamin D(3) status. Although sodium lauryl sulphate can increase markedly the calcium absorption from the gut and the immediate deposition in the bones it has no significant effect on rickets. 10. Some of the implications of these findings are discussed.

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Section: Discussionmentioning

confidence: 76%

mentioning

confidence: 99%

The effect of bile, bile acids and detergents on calcium absorption in the chick

Webling

Holdsworth

1965

Biochemical Journal

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“…They presented evidence to support their view that this was due to the capacity of bile salts to form The possible effects of triglyceride on calcium absorption in both normal and biliary-obstructed rats are complex, even in short-term experiments where any effect secondary to changes in vitamin D absorption can be eliminated. In the normal animal, calcium salts can be solubilized in a mixture of fatty acids and bile acids, and Klinke (1928) and Verzar and McDougall (1936) suggested that such a mixture may form a soluble complex in the intestine that could be absorbed intact by the mucosal cell, ionic calcium being only liberated within the body. More modern physico-chemical studies have shown that a micellar solution of bile salts and monoglycerides can incorporate polyvalent cations such as calcium, and it has been suggested that this micellar solubilization could play a role in normal calcium absorption (Hofmann, 1965).…”

Section: Discussionmentioning

confidence: 99%

Calcium absorption in the normal, bile-duct ligated, and cirrhotic rat, with observations on the effect of long- and medium-chain triglycerides.

Kehayoglou¹,

Williams²,

Whimster³

et al. 1968

Gut

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“…(ii) 3-431 (iii) 3:617 (iv) :3 601 5 (i) [5][6][7][8][9][10][11][12][13][14] (ii) as good as in health. Schaap12 found that the percentage of nlitIrogeln inl the foeces was practically the same as normal: owsing to the excess in the anmount of fiuces passed there wN-as natuirally a miuch greater loss of nitrogeni than in health.…”

Section: Atctiives Of Disease In Childhoodmentioning

confidence: 99%

Metabolism Studies in C liac Disease

Macrae¹,

Morris²

1931

Archives of Disease in Childhood

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Since the publication of Cheadle's paper' in 1903, the presence of excess of fat in the foeces has attracted much notice as the most characteristic signi of the metabolic disturbainee in cceliac disease. It ha,s beein recognized that associated with this disturbance of fat absorption, there occuirs also a defective retention of minerals and an excessive loss of nitroge.n in the feeces. In consequence some attention hias been paid to the effect of varying the composition of the dietarv, especially fromi the therapeuitic standpoint. The interrelationship of the disturbanices in the absorption of the various elements of the diet is a m4atter of importance both from the practical point of view, an(d l)ecause of the possible value in the explanation of other metabolic disor(lers.Parsons2 has already indicated the importa,nce of vitanmin D in the preventioni of cceliac rickets, showing that the continued absence of this vitanmin from the fat-poor diets used in treatment is the cause of the rickets of convalescence. The series of observations detailed in this paper are published in the hope that some further light nay be throwin onl the und(lerlying chemical pathology of the cceliac state. A more complete understanding of the disorder should ultimately prove of value in the prevention and cure of the disease.Metabolic studies in eoliae disease are subject to the great disadva,ntage that sudden changes oecur in the condition of the patient although the diet is constant and the environment unaltered. Accordingly it is difficult to determine whether differences in the metabolic findings are to be attribuited to changes in food or other treatment, or to nattural aggravation or amelioration of the condition. In these investigations as unich care as possible was taken to rule out the idiopathic changes in the severity of the disease. A brief description of the salient featuires of the case-histories of the patients is appended at the end of the paper (see Appendix). It is proposed in the first place to summarize the metabolic findings with regard to the various forms of foodstuffs and thereafter to discuiss the bearing of these results on the chemical pathogenesis of coeliac disease.

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Neuere Ergebnisse der Calciumforschung

Cited by 102 publications

References 145 publications

The effect of bile, bile acids and detergents on calcium absorption in the chick

The effect of bile, bile acids and detergents on calcium absorption in the chick

Calcium absorption in the normal, bile-duct ligated, and cirrhotic rat, with observations on the effect of long- and medium-chain triglycerides.

Metabolism Studies in C liac Disease

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