Neue Substanz zur therapeutischen Embolisation von Nierentumoren

Abstract

We report on a radio opaque substance for the embolization of kidney tumours which consists of amino acids mixed up with a contrast medium. It is relatively easy to be injected and can be well directed because of its radio-opacity. Past and recent histological examinations of embolized pig kidneys show that this material provides a durable closure of the vessels and that there is no essential tendency of intravasal dissolution. It is therefore also suitable for palliative embolizations. The first results in clinical trial have proved to be encouraging.

Penile Corporeal Fibrosis Complicating Papaverine Self-Injection Therapy for Erectile Impotence

“…A bundle of embolic agents has been used, but in renal cancer patients, only a few of them are currently employed. The most common materials [Bernstein and Kricheff, 1979], the gianturco device [Wallace et al, 1976], butyl-2-cyanoacrylate (Histoacryl®) [Freeny et al, 1979] and prolamine (Ethibloc®) [Bücheier et al, 1978]. Although most of the embolic agents are suitable for short term preoperative application, the arterial occlusion often recovers within few weeks [Tolle and Cramer, 1983].…”

“…Although most of the embolic agents are suitable for short term preoperative application, the arterial occlusion often recovers within few weeks [Tolle and Cramer, 1983]. Definite occlusion can be reached with Histoacryl®, when appropriate requirements are observed and a mixture of butyl-2-cyanoacrylate, 50% glucose and tantalum powder is used for embolization [Günther et al, 1978], A quick, safe and technically simple blockade can be achieved by Ethibloc®, but cases of recanalization are reported [Bücheier et al, 1978], Experience with embolization by absolute ethanol [Ellman et al, 1981;Tolle and Cramer, 1983] with favorable results and mini mal postembolization side effects has recently been reported. The particular advantages of embolization using ethanol are: the risk of dispersal of particles is minimized and the embolization effect is excellent even in the peripheral tissue compared to other emboliza tion materials.…”

Experimental Basis of Angioinfarction for the Treatment of Renal Hypertension

“…This is available in sterilized 7.5-ml syringes containing an alcoholic solution (60%) of 210mg/ml zein (com protein-occluding agent), 162mg/ml sodium amido-trizoate (contrast medium), 145 mg/ml oleum papaveris (prevents file formation) and 6 mg/ml propylene glycol (désinfectant). The occlu sion mechanism is precipitation of the alcohol-soluble zein in con tact with water or blood [10,31,45]. Ethibloc is admitted by the Bundcsgesundheitsamt Berlin for preoperative embolization of renal cell carcinoma and occlusion of the pancreatic duct (No.…”

“…Particulate substances adapted for vaso-occlusion, i.e. Gelfoam [2,4,57], Tachotop [44], Ivalon [15,22], Fibrospum [10,15], are transported more peripherally, but early resorption and incomplete 'embolization pattern' lead to recanalization [47], Ethibloc is the first embolization medium especially developed for peripheral intravascular transport [10], Its properties for reducing the efficiency of collateral supply were studied and compared with the effect of renal artery ligation (central occlusion type), Gelfoam powder (pe ripheral occlusion type) and Histoacryl/Lipiodol (capil lary occlusion type). …”