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Production of hydrocephalus in animal experiment has been difficult and not uniformly successful so far. The preparation Ethibloc (supplied by Ethicon, Hamburg-Norderstedt), which is a protein solution in alcohol, and which has been in use in abdominal surgery for occluding the pancreatic duct system, enables production of an obstructive hydrocephalus easily and with reproducible results. The authors report on 24 cases of development of an obstructive hydrocephalus in rabbits after Ethibloc had been introduced into the ventricular system.