Neue herzwirksame Drogen

Wagner, H; Reiter, Mercedes Gabriela Ratto; Ferstl, W.

doi:10.1055/s-2008-1074944

Cited by 31 publications

(1 citation statement)

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“…It is known for its insecticidal, antimicrobial [ 15 , 16 ], and mosquitocidal activities [ 17 ]. Antidiabetic [ 18 ], cardiotonic [ 19 , 20 ], antioxidant, and anti-lipidimic properties [ 21 ] of its leaves have been demonstrated. The anti-tumor activity of the annonaceous acetogenins from the seeds [ 22 ], the anti-cancer activity of the leaves and stem extract [ 23 ], and the genotoxicity of the methanolic fraction of the seeds [ 24 ] have been recorded.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Effect on Plasmodium falciparum and In Vivo Effect on Plasmodium berghei of Annomaal, an Oily Fraction Obtained from the Seeds of Annona squamosa

2023

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Malaria remains a life-threatening health problem and is responsible for the high rates of mortality and morbidity in the tropical and subtropical regions of the world. The increasing threat of drug resistance to available artemisinin-based therapy warrants an urgent need to develop new antimalarial drugs that are safer, more effective, and have a novel mode of action. Natural plants are an excellent source of inspiration in searching for a new antimalarial agent. This research reports a systematic investigation for determining the antimalarial potential of the seeds of A. squamosa. The study shows that the crude seed extract (CSE), protein, saponin, and the oily fractions of the seeds were nontoxic at a 2000 mg/kg body weight dose when tested in Wistar rats, thus revealing high safety is classified as class 5. The oily fraction, Annomaal, demonstrated pronounced antimalarial activity with low IC50 (1.25 ± 0.183 μg/mL) against P. falciparum in vitro. The CSE and Annomaal significantly inhibited the growth of P. berghei parasites in vivo with 58.47% and 61.11% chemo suppression, respectively, while the standard drug artemether showed chemo suppression of 66.75%. Furthermore, the study demonstrated that oral administration of Annomaal at a daily dose of 250 mg/kg/day for 3 days was adequate to provide a complete cure to the P. berghei-infected mice. Annomaal thus holds promise as being patient-compliant due to the shorter treatment schedule, eliminating the need for frequent dosing for extended time periods as required by several synthetic antimalarial drugs. Further studies are needed to determine the active compounds in the oily fraction responsible for antimalarial activity.

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Section: Introductionmentioning

confidence: 99%

In Vitro Effect on Plasmodium falciparum and In Vivo Effect on Plasmodium berghei of Annomaal, an Oily Fraction Obtained from the Seeds of Annona squamosa

2023

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A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline alkaloid reticuline

Stadler

Zenk

1990

Liebigs Ann. Chem.

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The label from (S)‐[1‐13C]norcoclaurine and (S)‐[1‐13C]co‐claurine was highly and nonrandomly incorporated into (S)‐reticuline in benzyltetrahydroisoquinoline‐producing plant cell cultures of Berberis stolonifera, Eschscholtzia californica and Peumus boldus. From the intermediates observed in vivo we conclude that (S)‐norcoclaurine is stereoselectively metabolized to (S)‐reticuline via (S)‐coclaurine, (S)‐N‐methylcoclaurine and (S)‐3′‐hydroxy‐N‐methylcoclaurine. These results confirm a revised pathway to the benzylisoquinoline alkaloids.

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Major Australian tropical fruits biodiversity: Bioactive compounds and their bioactivities

Pierson

Dietzgen

Shaw

et al. 2011

Molecular Nutrition Food Res

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The plant kingdom harbours many diverse bioactive molecules of pharmacological relevance. Temperate fruits and vegetables have been highly studied in this regard, but there have been fewer studies of fruits and vegetables from the tropics. As global consumers demand and are prepared to pay for new appealing and exotic foods, tropical fruits are now being more intensively investigated. Polyphenols and major classes of compounds like flavonoids or carotenoids are ubiquitously present in these fruits, as they are in the temperate ones, but particular classes of compounds are unique to tropical fruits and other plant parts. Bioactivity studies of compounds specific to tropical fruit plants may lead to new drug discoveries, while the synergistic action of the wide range of diverse compounds contained in plant extracts underlies nutritional and health properties of tropical fruits and vegetables. The evidence for in vitro and animal bioactivities is a strong indicator of the pharmacological promise shown in tropical fruit plant biodiversity. In this review, we will discuss both the occurrence of potential bioactive compounds isolated and identified from a selection of tropical fruit plants of importance in Australia, as well as recent studies of bioactivity associated with such fruits and other fruit plant parts.

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Neue herzwirksame Drogen

Cited by 31 publications

References 0 publications

In Vitro Effect on Plasmodium falciparum and In Vivo Effect on Plasmodium berghei of Annomaal, an Oily Fraction Obtained from the Seeds of Annona squamosa

In Vitro Effect on Plasmodium falciparum and In Vivo Effect on Plasmodium berghei of Annomaal, an Oily Fraction Obtained from the Seeds of Annona squamosa

A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline alkaloid reticuline

Major Australian tropical fruits biodiversity: Bioactive compounds and their bioactivities

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