Neue Empfehlungen für die Umgebungsuntersuchungen bei Tuberkulose*

Diel, Roland; Loytved, G.; Nienhaus, Albert; Castell, Stefanie; Detjen, Anne; Geerdes-Fenge, H.; Haas, Walter; Hauer, Barbara; Königstein, B.; Maffei, Daniele Fernanda; Magdorf, K.; Priwitzer, Martin; Jp, Zellweger; Loddenkemper, R.

doi:10.1055/s-0030-1256574

Cited by 21 publications

(30 citation statements)

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“…For practical purposes, in some recommendations [70,71], a cumulative exposure time necessary for defining a ''close'' versus ''casual'' non-household contact has been stated, e.g. of 8 h, if the index case is AFB smear-positive, or 40 h, if only sputum culture-positive, but the duration and frequency of cough in the source case may outweigh the time factor for establishing contact categories (fig 1) [72].…”

Section: Indications For Preventive Treatmentmentioning

confidence: 99%

Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination

Diel

Loddenkemper

Zellweger³

et al. 2013

Eur Respir J

156

129

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The introduction of new rapid diagnostic tools for tuberculosis (TB) and the promising TB drugs pipeline together with the development of a new World Health Organization Strategy post 2015 allows new discussions on how to direct TB control. The European Respiratory Society's European Forum for TB Innovation was created to stimulate discussion on how to best take advantage of old and new opportunities, and advances, to improve TB control and eventually progress towards the elimination of TB.While TB control is aimed at reducing the incidence of TB by early diagnosis and treatment of infectious cases of TB, TB elimination requires focus on sterilising the pool of latently infected individuals, from which future TB cases would be generated.This manuscript describes the three core components that are necessary to implement the elimination strategy fully. 1) Improve diagnosis of latent TB infected individuals. 2) Improve regimens to treat latent TB infection. 3) ensure public health commitment to make both 1) and 2) possible. Old and new evidence is critically described, focusing on the European commitment to reach elimination and on the innovative experiences and best practices available. @ERSpublications Diagnosis and treatment of latent TB infection is the core intervention to reach elimination

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Section: Indications For Preventive Treatmentmentioning

confidence: 99%

Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination

Diel

Loddenkemper

Zellweger³

et al. 2013

Eur Respir J

156

129

View full text Add to dashboard Cite

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“…By raising the cut-off from 5 mm to 10 mm in BCG-vaccinated contacts, 25 % of the tests turned false negative and the authors concluded that IGRAs were more accurate indicators of LTBI than TST. In line with that observation, new German guidelines (35) recommend that only IGRA is used to test adult contacts who were at least partially BCGvaccinated, while TST is preferred for children younger than fi ve years.…”

Section: Igra In Contact Investigationmentioning

confidence: 90%

“…Weak cellular immune response is usually the reason why IGRA results are more often indeterminate in children than in adults (33). Some even prefer TST in diagnosing LTBI in smaller children over IGRA (27,34,35). This preference stems from the fact that TST obtains a stronger immunological response, as it stimulates central memory cells over a longer incubation time, while QFT responses result from effector cells in peripheral blood.…”

Section: Igra In Childrenmentioning

confidence: 99%

The Role of Interferon-gamma Release Assay in Tuberculosis Control

Savičević

Katalinić-Janković

Mise

et al. 2012

Archives of Industrial Hygiene and Toxicology

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The Role of Interferon-gamma Release Assay in Tuberculosis ControlTuberculosis is still one of the major global public health threats. Countries with low incidence must focus on exhausting the reservoir of future cases by preventing reactivation. Therefore, it is important to identify and effectively treat those individuals who have latent tuberculosis infection and who may develop active disease. The tuberculin skin test has been the standard for detection of immune response against M. tuberculosis since the beginning of the 20th century. The new millennium has brought advancement in the diagnosis of latent tuberculosis infection. The name of the new blood test is interferon-gamma release assay (IGRA). Croatia is a middle-incidence country with a long decreasing trend and developed tuberculosis control. To reach low incidence and finally eliminate tuberculosis, its tuberculosis programme needs a more aggressive approach that would include intensive contact investigation and treatment of persons with latent tuberculosis infection. This article discusses the current uses of IGRA and its role in tuberculosis control.

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“…The use of two different test systems impaired the overall comparability of the data but reflected clinical practice in the 18 centres involved. Tuberculin skin tests were not regularly performed according to German guidelines [7]. The laboratory staff was blinded to the clinical data, vaccination status and tuberculosis disease status of the participants.…”

Section: Early Bcg Vaccination Is Unrelated To Pulmonary Immunity Agamentioning

confidence: 99%

Early BCG vaccination is unrelated to pulmonary immunity againstMycobacterium tuberculosisin adults

et al. 2014

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Neue Empfehlungen für die Umgebungsuntersuchungen bei Tuberkulose*

Abstract: In 2007, the German Central Committee against Tuberculosis (DZK) published recommendations for contact tracing that introduced the new interferon gamma release assays (IGRAs

Cited by 21 publications

References 1 publication

Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination

Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination

The Role of Interferon-gamma Release Assay in Tuberculosis Control

Early BCG vaccination is unrelated to pulmonary immunity againstMycobacterium tuberculosisin adults

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