Networks of MicroRNAs and Genes in Retinoblastomas

Li, Jie; Xu, Zhinan; Wang, Kunhao; Wang, Ning; Li, Deqiang; Wang, Shang

doi:10.7314/apjcp.2013.14.11.6631

Cited by 10 publications

(12 citation statements)

References 9 publications

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“…CTNNB1 exhibits a significant role in WT, while it is also involved in hepatoblastoma (18). Furthermore, hsa-let-7a is differentially expressed in WT, and is also overexpressed in retinoblastoma (19). The present study provides a novel perspective for biologists with regard to WT treatment.…”

Section: Discussionmentioning

confidence: 93%

Networks analysis of genes and microRNAs in human Wilms' tumors

Guo

Sun

et al. 2016

Oncology Letters

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Abstract. Wilms' tumor (WT) is a common kidney cancer. To date, the expression of genes [transcription factors (TFs), target genes and host genes] and microRNAs (miRNAs/miRs) in WTs has captured the attention of biologists, while the regulatory association between the genes and miRNAs remains unclear. In the present study, TFs, miRNAs, target genes and host genes were considered as key factors in the construction of three levels of regulatory networks, namely, the differentially-expressed network, the related network and the global network. The four factors had three types of association, including the regulation of miRNAs by TFs, the targeting of the target genes by miRNAs and the location of miRNAs at host genes. The differentially-expressed network is the most important of the three networks, and only involves the differentially-expressed genes and miRNAs; with the exception of host genes, those elements all behave abnormally when a WT occurs, which suggests that the differentially-expressed network can accurately reveal the pathogenesis of WTs. E2F3, for example, is overexpressed in WTs, and it regulates hsa-let-7a, hsa-let-7a-1, hsa-miR-106b, among others. Meanwhile, E2F3 is targeted by hsa-miR-106b, hsa-miR-17 and hsa-miR-20a. If the regulatory network can be used to adjust those factors to a normal level, there may be a chance to cure patients with WTs. WT-associated factors were placed into the related network; this network is useful for understanding the regulatory pathways of genes and miRNA in WTs. The networks provide a novel perspective in order to study the inner interactions of genes and miRNAs. The present study provides authoritative data and regulatory pathway analysis in order to partially elucidate the pathogenesis of WT, and thus supplies biologists with a basis for future research.

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Section: Discussionmentioning

confidence: 93%

Networks analysis of genes and microRNAs in human Wilms' tumors

Guo

Sun

et al. 2016

Oncology Letters

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“…A previous study indicated that MYCN is not only differentially expressed in HB, but also in Wilms' tumor (33). Furthermore, hsa-miR-373 is overexpressed in HB, and is also differentially expressed in retinoblastoma (34). Future studies should focus on the genes and miRNAs that are common in various types of cancer.…”

Section: Discussionmentioning

confidence: 99%

Regulatory network analysis of genes and microRNAs in human hepatoblastoma

Guo

Sun

et al. 2016

Oncology Letters

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Abstract. Hepatoblastoma (HB) is a common type of primary tumor in children. Previous studies have examined the expression of genes, including transcription factors (TFs), target genes, host genes and microRNAs (miRNAs or miRs) associated with HB. However, the regulatory pathways of miRNAs and genes remain unclear. In the present study, a novel perspective is proposed, which focuses on HB and the associated regulatory pathways, to construct three networks at various levels, including a differentially expressed network, an associated network and a global network. Genes and miRNAs are considered as key factors in the network. In the three networks, the associations between each pair of factors, including TFs that regulate miRNAs, miRNAs that interact with target genes and miRNAs that are located at host genes, were analyzed. The differentially expressed network is considered to be the most crucial of the three networks. All factors in the differentially expressed network were mutated or differentially expressed, which indicated that the majority of the factors were cancerogenic factors that may lead to HB. In addition, the network contained numerous abnormal linkages that may trigger HB. If the expression of each factor was corrected to a normal level, HB may be successfully treated. The associated network included more HB-associated genes and miRNAs, and was useful for analyzing the pathogenesis of HB. By analyzing these close associations, the first and the last factor of the regulatory pathways were revealed to have important roles in HB. For example, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) was observed to regulate Homo sapiens (hsa)-miR-221, hsa-miR-18a and hsa-miR-17-5p, but no miRNAs targeted MYCN. In conclusion, the pathways and mechanisms underlying HB were expounded in the present study, which proposed a fundamental hypothesis for additional studies.

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“…RB is a common intraocular malignant tumor in infants (Khaenam et al, 2012;Khan et al, 2013;Li et al, 2013;Maiti et al, 2013;Srivastava et al, 2013;Romus et al, 2013). Some children have been sick at birth and appear vision loss and even blindness in the early stage.…”

Section: Discussionmentioning

confidence: 99%