Network reconstruction reveals new links between aging and calorie restriction in yeast

We Are Ageing

“…To date, the most promising leads for longevity are caloric restriction [ 5 , 6 ], targeting of rapamycin (TOR) [ 123 ], sirtuins [ 124 ], hexarelin [ 125 ], and hormetic responses [ 126 ]. Treated mice with resveratrol histone deacetylase sirtuin-1 (HDAC SIRT1) and high-fat diet increase life span, apparently mimicking the well-established contribution of caloric restriction to longevity [ 127 ].Chromatin-modifying agents are currently being tested as novel cancer therapies [ 128 ].…”

“…Lately, many tactics have been proposed for enhancing human longevity [ 4 ] with varying degrees of success. Such example is a caloric restriction [ 5 , 6 ], hormonal replacement [ 7 ], and antioxidant treatment [ 8 , 9 ]. Also, some strategies for enhancing human longevity were introduced, for example, engineered negligible senescence proposed by De Grey [ 10 ] and nucleic acid therapy; see review by Lai [ 11 ].…”

Nucleic acid therapy for lifespan prolongation: Present and future

“…Over the years, copious tactics have been proposed to battle for enhancing longevity (Lai and Chan 2011), and have exhibited various degrees of success. For instance, caloric restriction was reported to delay mortality and the onset of diseases such as arcopenia in rhesus monkeys (Balazsi 2010;Colman et al 2009;McKiernan et al 2011), whereas hormonal replacement was found to promote healthy longevity (Kahn 2005;Yonei et al 2007) and be therapeutic to hypergonadotropic hypogonadism in females (Dragojević-Dikić et al 2009). Other important examples of longevity enhancing tactics include 'Strategies for Engineered Negligible Senescence' (de Grey 2005) and antioxidant treatments (Baxter 2008;Head 2009).…”