Network pharmacology-based identification of the protective mechanisms of taraxasterol in experimental colitis

Chen, Wei; Da, Wang; Li, Chen; Fan, Hui‐Ning; Liang, Rui; Yuan, Junqing; Huang, Xiaoqing; Yang, Renzhi; Zhang, Jing; Zhu, Jingde

doi:10.1016/j.intimp.2019.03.042

Cited by 23 publications

(10 citation statements)

References 33 publications

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“…One previous study found that a Taraxacum officinale polysaccharide can ameliorate ulcerative colitis (Wang et al 2017). Another study demonstrated that taraxasterol is effective in the treatment of acute colitis in vivo (Chen et al 2019a). Finally, a study by Chen et al (2019b) showed that Taraxacum officinale extract is able to improve the symptoms of colitis controlling fatty acid metabolism and dysbiosis (Table1).…”

Section: Activity Against Colitismentioning

confidence: 99%

A comprehensive review of the benefits of Taraxacum officinale on human health

Napoli¹,

Zucchetti²

2021

Bull Natl Res Cent

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Background Taraxacum officinale (G.H. Weber ex Wiggers), commonly known as dandelion, is a herbaceous plant native to North America, Europe and Asia. This plant has been used for health purposes since ancient times. The phytochemicals present in different parts of the plant are responsible for its medicinal properties. In this review, we describe the main health properties of Taraxacum officinale. Main body of the abstract We searched for the main medicinal properties of Taraxacum officinale in the scientific literature, using the PubMed database. We selected 54 studies and we described twelve therapeutic properties, which are reported in previous studies. These properties are diuretic, hepatoprotective, anticolitis, immunoprotective, antiviral, antifungal, antibacterial, antiarthritic, antidiabetic, antiobesity, antioxidant and anticancer effects. We also found that the most frequently reported therapeutic effects include hepatoprotective, antioxidant and anticancer activities. Short conclusion In this review, we describe the medicinal properties of Taraxacum officinale reported in previous studies. Antioxidant, hepatoprotective and anticancer effects are mostly found in the scientific literature.

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Section: Activity Against Colitismentioning

confidence: 99%

A comprehensive review of the benefits of Taraxacum officinale on human health

Napoli¹,

Zucchetti²

2021

Bull Natl Res Cent

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“…According to the previous description, 4 immunohistochemistry (IHC) analysis was conducted. The tumor tissues were immune-stained for phospho-EGFR (AF3048), phospho-AKT1 (AF0832), anti-EGFR (ET1604-44), anti-BRAF (ET1608-36), anti-fibroblast growth factor receptor 2 (anti-FGFR2; EM50103), anti-AKT1 (ET1609-47) and anti-matrix metalloproteinase 2 (anti-MMP2; ET1606-4), respectively.…”

Section: Immunohistochemistrymentioning

confidence: 99%

“…Mounting evidence indicated that TAX possesses a variety of biological activities including anti-inflammatory and antitumor activity. 4,5 TAX can suppress in vivo breast carcinogenesis and in vitro cell growth in colorectal cancer, cervical cancer, and melanoma. 5,6 Nevertheless, the effects and underlying mechanism of TAX in GC remain unreported.…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology-based identification of the antitumor effects of taraxasterol in gastric cancer

Chen

et al. 2020

Int J Immunopathol Pharmacol

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Taraxasterol (TAX), a pentacyclic triterpene, has been reported to exhibit potent antitumor activity. However, the effects and molecular mechanisms of TAX in gastric cancer (GC) remain undocumented. A network pharmacology approach was applied to identify the collective targets of TAX and GC. Nude mice were subcutaneously injected with MKN-28 cells to establish GC subcutaneous xenograft model, which were treated with TAX for 16 days. Tumor volume was then examined every other day. The pathological scoring was assessed by using hematoxylin and eosin (H&E) staining, and the expression levels of Ki-67 and the target genes of TAX were confirmed by immunohistochemistry analysis. Five collective targets of TAX and GC were identified, such as epidermal growth factor receptor (EGFR), matrix metalloproteinase 2 (MMP2), B-Raf proto-oncogene, serine/threonine kinase (BRAF), fibroblast growth factor receptor 2 (FGFR2), and AKT serine/threonine kinase 1 (AKT1). Further investigations showed that, TAX administration repressed xenograft tumor growth and decreased Ki-67 levels, followed by the downregulation of EGFR and AKT1 expression in xenograft tumor tissues as compared with the untreated group. Our findings demonstrated that TAX inhibited the growth of GC by inhibition of EGFR/AKT1 signaling and might provide a novel therapeutic strategy for treatment of GC.

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“…To investigate the relationship of XTN and CHD, the drug-components-targets network and protein interaction(PPI) network were constructed with Cytoscape 3.6.0 software(https://cytoscape.org/) [30].…”

Section: Network Constructionmentioning

confidence: 99%

Investigating the pharmacological mechanisms of SheXiang XinTongNing against coronary heart disease based on network pharmacology

Jia

Cao³

et al. 2020

Preprint

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Background SheXiang XinTongNing, a commercially available Chinese patent medicine, has been widely used in the treatment of coronary heart disease. However, the mechanisms of SheXiang XinTongNing are still unclear. The aim of this study was to investigate the pharmacological mechanisms of SheXiang XinTongNing against coronary heart disease via network analysis. Method The traditional Chinese medicine system pharmacology analysis platform was used to screen the potential active constituents of the six traditional Chinese medicines in SheXiang XinTongNing, and the potential targets were obtained from PharmMapper. The genome annotation database platform was used to screen the candidate targets related to coronary heart disease. Then the drug-components-targets network and protein interaction network were built by Cytoscape 3.6.0 software. Further, GO bio-functional enrichment analysis and KEGG pathway enrichment analysis were performed through annotation, visualization and integrated discovery database. Results Results showed that the drugs-components-targets network contains 104 targets and 62 key components. The protein interaction network consisted of 107 nodes; key targets included Bcl2l1, IGF1, SRC, CASP3, et al. Functionally, the candidate targets were significantly associated with multiple pathways such as PI3K-Akt signaling pathway, MAPK signaling pathway, Ras signaling pathway, FoxO signaling pathway, Endocrine resistance. Given the above, the pharmacological activities of SheXiang XinTongNing may be predominantly related to several factors such as cell apoptosis, inflammation and angiogenesis. Conclusion XTN can effectively attenuate the symptoms of coronary heart disease through diverse pathways. The research proves that network pharmacology can successfully reveal the mechanisms of traditional Chinese medicine in a holistic view. Our systematic analysis lays a foundation for further studying.

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Network pharmacology-based identification of the protective mechanisms of taraxasterol in experimental colitis

Cited by 23 publications

References 33 publications

A comprehensive review of the benefits of Taraxacum officinale on human health

A comprehensive review of the benefits of Taraxacum officinale on human health

Network pharmacology-based identification of the antitumor effects of taraxasterol in gastric cancer

Investigating the pharmacological mechanisms of SheXiang XinTongNing against coronary heart disease based on network pharmacology

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