Network Meta-Analysis Comparing Relatively Selective COX-2 Inhibitors Versus Coxibs for the Prevention of NSAID-Induced Gastrointestinal Injury

Yang, Man; Wang, Hong-Tao; Zhao, Miao; Meng, Wenbo; Ou, Jin-Qing; He, Junhui; Zhu, Bing; Lei, Pingguang

doi:10.1097/md.0000000000001592

Cited by 39 publications

(36 citation statements)

References 54 publications

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“…Analgesic drugs are used in relieving pain caused by various inflammatory disorders, but they do not reduce the pain in the heart, liver and kidney. Usage of this drug in a therapeutic dosage is beneficial and advisable for health, but on frequent usage and in higher doses it would lead to the damage of various organs in the body (Yang et al ., ). Each day about 30 million of the world's population are using NSAIDs.…”

Section: Non‐steroidal Anti‐inflammatory Drugsmentioning

confidence: 97%

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Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Simon

Sabina

2016

J of Applied Toxicology

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The liver is an important organ of the body, which has a vital role in metabolic functions. The non-steroidal anti-inflammatory drug (NSAID), diclofenac causes hepato-renal toxicity and gastric ulcers. NSAIDs are noted to be an agent for the toxicity of body organs. This review has elaborated various scientific perspectives of the toxicity caused by diclofenac and its mechanistic action in affecting the vital organ. This review suggests natural products are better remedies than current clinical drugs against the toxicity caused by NSAIDs. Natural products are known for their minimal side effects, low cost and availability. On the other hand, synthetic drugs pose the danger of adverse effects if used frequently or over a long period. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Non‐steroidal Anti‐inflammatory Drugsmentioning

confidence: 97%

“…In leukocytes, diclofenac reduces the intracellular content of amino acids (Yang et al ., ). Various studies have reported the effects of diclofenac that would lead to hepatitis and hepatotoxicity (Gómez‐Lechón et al ., ).…”

Section: Diclofenacmentioning

confidence: 99%

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Simon

Sabina

2016

J of Applied Toxicology

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“…COX‐1 promotes production of the mucosal lining, which serves to protect the gastrointestinal (GI) tract. Inhibition of COX‐1 increases the potential risk of GI side effects [9,10]. COX‐1 inhibition also decreases synthesis of thromboxane in platelets, thereby interfering with platelet aggregation, which confers an increased bleeding risk [9,10].…”

Section: Nsaid Pharmacologymentioning

confidence: 99%

Safety Considerations in Prescription of NSAIDs for Musculoskeletal Pain: A Narrative Review

Hatt

Vijapura

Maitin

et al. 2018

PM&R

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed for the treatment of painful musculoskeletal conditions. When prescribing oral NSAIDs, clinicians must consider coexisting cardiovascular, cerebrovascular, gastrointestinal, and renal disease because oral NSAIDs are associated with a broad spectrum of adverse effects on these systems. The different safety profiles of NSAIDs can be attributed to differences in the extent to which the drug inhibits cyclo-oxygenase-1 vs -2 and their potential for drug-drug interactions. This narrative review intends to guide the clinician in prescribing oral NSAIDs while taking into consideration these comorbid conditions and drug interactions.

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“…Закономерно было бы предположить, что использование высокоселективных коксибов сопровождалось еще большим ростом безопасности со стороны ЖКТ. Действительно, применение высокоселективных ингибиторов ЦОГ-2 (коксибов) уменьшало риск развития гастродуоденальных язв (снижение относительного риска на 74%) и язвенных осложнений (снижение на 61%) по сравнению с неселективными НПВП [14]. Однако, как часто бывает в медицине, дальнейший рост селективности в отношении ЦОГ-2, не сопровождался значимым увеличением безопасности в отношении ЖКТ.…”

Section: Conflict Of Interestunclassified

Safe use of meloxicam in clinical practice

Сас

Гриневич

2019

Med. sov.

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Non-steroidal anti-inflammatory drugs (NSAIDs) – means of treatment of acute and chronic pain associated primarily with inflammatory changes, so this group of drugs is widely used in neurology, rheumatology, traumatology, etc. The mechanism of action of the drugs is associated with the effect on cyclooxygenase-2 (COG-2) and blockade of proinflammatory prostaglandins (PG) synthesis, as well as the effect on COG-1 and suppression of cytoprotective PG synthesis, which determines the possibility of side effects from the gastrointestinal tract (GIT). Now application of NPVP is focused not so much on increase of efficiency, as on their big safety. Creation of COG-2-selective inhibitors (meloxicam) and COG-2-high selective inhibitors (coxybes) allowed to reduce significantly the risk of complications from gastrointestinal tract while maintaining high efficiency. Thus, the safety profile of meloxicam, mainly inhibiting COG-2, is estimated in a whole series of studies. In particular, two large prospective controlled trials - MELISSA and SELECT - proved that meloxicam is less toxic to gastrointestinal tract than traditional NSAIDs. Thus, a reasonable conclusion can be made about the high efficacy of meloxicam, which is not inferior to that of non-selective NSAIDs, with good tolerability and safety of the drug against gastrointestinal tract.

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Network Meta-Analysis Comparing Relatively Selective COX-2 Inhibitors Versus Coxibs for the Prevention of NSAID-Induced Gastrointestinal Injury

Abstract: Supplemental Digital Content is available in the text

Cited by 39 publications

References 54 publications

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Safety Considerations in Prescription of NSAIDs for Musculoskeletal Pain: A Narrative Review

Safe use of meloxicam in clinical practice

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