Network Formation of Tissue Cells via Preferential Attraction to Elongated Structures

Szabó, András; Perryn, Erica D.; Czirók, András

doi:10.1103/physrevlett.98.038102

Cited by 57 publications

(99 citation statements)

References 23 publications

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“…Instead they proposed that cells are preferentially attracted to locally elongated configurations of cells [52] , or that cells adhere most strongly to elongated cells [51]. This mechanism produces vascular-like network patterns (Fig.…”

Section: Preferential Attachment To Elongated Structuresmentioning

confidence: 99%

“…Panel E reprinted with permission from Ref. [52]. Copyright (2007) by the American Physical Society.…”

Section: Preferential Attachment To Elongated Structuresmentioning

confidence: 99%

“…D. Overdamped chemotactic motion of round endothelial cells with contact-inhibition of motility. E and F. Preferential attraction to elongated cellular configurations [52,51]. Panel E reprinted with permission from Ref.…”

Section: Preferential Attachment To Elongated Structuresmentioning

confidence: 99%

“…Szabo and coworkers [52,51] observed that non-vascular (glia-and muscle related) cells can form irregular networks on rigid tissue culture substrates with continuously shaken culture medium, hence excluding traction-based or chemotaxis-based patterning mechanisms. Instead they proposed that cells are preferentially attracted to locally elongated configurations of cells [52] , or that cells adhere most strongly to elongated cells [51].…”

Section: Preferential Attachment To Elongated Structuresmentioning

confidence: 99%

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Modeling Morphogenesisin silicoandin vitro: Towards Quantitative, Predictive, Cell-based Modeling

Merks

Koolwijk

2009

Math. Model. Nat. Phenom.

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Abstract. Cell-based, mathematical models help make sense of morphogenesis-i.e. cells organizing into shape and pattern-by capturing cell behavior in simple, purely descriptive models. Cell-based models then predict the tissue-level patterns the cells produce collectively. The first step in a cell-based modeling approach is to isolate sub-processes, e.g. the patterning capabilities of one or a few cell types in cell cultures. Cell-based models can then identify the mechanisms responsible for patterning in vitro. This review discusses two cell culture models of morphogenesis that have been studied using this combined experimental-mathematical approach: chondrogenesis (cartilage patterning) and vasculogenesis (de novo blood vessel growth). In both these systems, radically different models can equally plausibly explain the in vitro patterns. Quantitative descriptions of cell behavior would help choose between alternative models. We will briefly review the experimental methodology (microfluidics technology and traction force microscopy) used to measure responses of individual cells to their micro-environment, including chemical gradients, physical forces and neighboring cells. We conclude by discussing how to include quantitative cell descriptions into a cell-based model: the Cellular Potts model.

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Section: Preferential Attachment To Elongated Structuresmentioning

confidence: 99%

“…Panel E reprinted with permission from Ref. [52]. Copyright (2007) by the American Physical Society.…”

Section: Preferential Attachment To Elongated Structuresmentioning

confidence: 99%

Section: Preferential Attachment To Elongated Structuresmentioning

confidence: 99%

Section: Preferential Attachment To Elongated Structuresmentioning

confidence: 99%

See 2 more Smart Citations

Modeling Morphogenesisin silicoandin vitro: Towards Quantitative, Predictive, Cell-based Modeling

Merks

Koolwijk

2009

Math. Model. Nat. Phenom.

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“…The term w pol , previously introduced in CPMs describing formation and growth of elongated multicellular structures [66,67,68], accounts the polarization of tip vascular cells (i.e., their ability to differentiate in a leading and a trailing edge) and the resulting persistent directional migration, which alters the probability assigned to each spin update, as:…”

Section: Mathematical Modelmentioning

confidence: 99%

A cellular Potts model analyzing differentiated cell behavior during in vivo vascularization of a hypoxic tissue

Scianna

Bassino

Munaron

2015

Computers in Biology and Medicine

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Angiogenesis, the formation of new blood vessel networks from existing capillary or post-capillary venules, is an intrinsically multiscale process occurring in several physio-pathological conditions. In particular, hypoxic tissue cells activate downstream cascades culminating in the secretion of a wide range of angiogenic factors, including VEGF isoforms. Such diffusive chemicals activate the endothelial cells (ECs) forming the external walls of the nearby vessels, that chemotactictally migrate toward the hypoxic areas of the tissue as multicellular sprouts. A functional network eventually emerges by further branching and anastomosis processes. We here propose a CPM-based approach reproducing selected features of the angiogenic progression necessary for the reoxygenation of a hypoxic tissue. Our model is able to span the different scale involved in the angiogenic progression as it incorporates reaction-diffusion equations for the description of the evolution of microenvironmental variables in a discrete mesoscopic cellular Potts model (CPM) that reproduces the dynamics of the vascular cells. A key feature of this work is the explicit phenotypic differentiation of the ECs themselves, distin-1 E-Mail: marcosci1@alice.it 2 E-Mail: eleonora.bassino@unito.it 3 E-Mail: luca.munaron@unito.it Preprint submitted to Computers in Biology and Medicine May 25, 2015 guished in quiescent, stalk and tip. The simulation results allow identifying a set of key mechanisms underlying tissue vascularization. Further, we provide evidence that the nascent pattern is characterized by precise topological properties. Finally, we link abnormal sprouting angiogenesis with alteration in selected cell behavior.

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Pattern formation during vasculogenesis

Czirók

Little

2012

Birth Defects Research Pt C

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Vasculogenesis, the assembly of the first vascular network, is an intriguing developmental process that yields the first functional organ system of the embryo. In addition to being a fundamental part of embryonic development, vasculogenic processes also have medical importance. To explain the organizational principles behind vascular patterning, we must understand how morphogenesis of tissue level structures can be controlled through cell behavior patterns that, in turn, are determined by biochemical signal transduction processes. Mathematical analyses and computer simulations can help conceptualize how to bridge organizational levels and thus help in evaluating hypotheses regarding the formation of vascular networks. Here, we discuss the ideas that have been proposed to explain the formation of the first vascular pattern: cell motility guided by extracellular matrix alignment (contact guidance), chemotaxis guided by paracrine and autocrine morphogens, and sprouting guided by cell–cell contacts. Birth Defects Research (Part C) 96:153–162, 2012. © 2012 Wiley Periodicals, Inc.

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Network Formation of Tissue Cells via Preferential Attraction to Elongated Structures

Cited by 57 publications

References 23 publications

Modeling Morphogenesisin silicoandin vitro: Towards Quantitative, Predictive, Cell-based Modeling

Modeling Morphogenesisin silicoandin vitro: Towards Quantitative, Predictive, Cell-based Modeling

A cellular Potts model analyzing differentiated cell behavior during in vivo vascularization of a hypoxic tissue

Pattern formation during vasculogenesis

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