Network as biomarker

Ensemble inference by integrative cancer networks

“…Networks offer an interesting opportunity with regard to the study of markers: they allow to establish their relevance as individual entities and also as components of a cluster or module. Supported by recent literature (Dao et al, 2011 ; Peer and Hacohen, 2011 ; Bebek et al, 2012 ; Wu et al, 2012 ; Ben-Hamo and Efroni, 2013 ), we hypothesize that by switching their role, from individual to team players, markers may provide novel information on cancer, especially when studied in a pathway context. In particular, markers examined at a network scale may reveal their systems relationships, generating synergistically active candidates.…”