Network Analysis of Magnetoencephalogram Signals in Schizophrenia Patients When Viewing Emotional Facial Stimuli

Abstract

Schizophrenia is a serious mental disorder. Network analysis of magnetoencephalogram signals may help to identify potential biomarkers of schizophrenia. The goal of this investigation was to identify potential biomarkers in the magnetoencephalogram signals of patients with schizophrenia, global brain connectivity measures was used for emotion recognition in discriminating the patients from controls. First, we employed a mutual information method to explore the topological characteristics of the brain network in patients with schizophrenia among different frequency bands in response to four different stimulus conditions. Second, multidimensional cross-recurrence quantification analysis was performed to investigate the differences in dynamic coupling among different frequencies of brain magnetic waves in patients with schizophrenia in response to four different stimulus conditions, as the major novel contribution of our study. We found that the differences in topological features of the brain network appear in different frequency bands under different stimulus conditions. The differences are evident in the alpha 1 (8-10 Hz) and beta (13-30 Hz) frequency bands in response to negative stimuli, in the alpha 1 (8-10 Hz) frequency band in response to positive stimuli, and in the theta (4-8 Hz) and alpha 1 (8-10 Hz) frequency bands in response to neutral and gray-cross stimuli. In addition, differences in dynamic coupling among pairs of frequency bands were the most prominent in response to positive stimuli. The characteristics identified by our methods may be potential markers of schizophrenia present in magnetoencephalogram data, which can facilitate the clinical identification of schizophrenia patients. Our method provides a comprehensive perspective of brain networks in patients with schizophrenia and has practical applications for the clinical diagnosis of this disease.