Nesfatin-1 — Role as possible new potent regulator of food intake

Stengel, Andreas; Taché, Yvette

doi:10.1016/j.regpep.2010.05.002

Cited by 77 publications

(55 citation statements)

References 44 publications

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“…One of the most important functions of nesfatin-1 is reducing food intake. It causes loss of appetite, less frequent hunger, and a sense of fullness (3)(4)(5)(6). It has been demonstrated that pancreatic beta cells colocalize with nesfatin/NUCB2 in the islets of both mice and rats, indicating the possible involvement of nesfatin-1 in the regulation of insulin secretion from pancreatic beta cells (7).…”

Section: Introductionmentioning

confidence: 99%

Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes

Ademoglu¹,

Gorar

Keskin

et al. 2017

Arch. Endocrinol. Metab.

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Objective: To investigate serum nesfatin-1 levels at 24-28 weeks of pregnancy in women newly diagnosed with gestational diabetes and determine the association of nesfatin-1 with several metabolic parameters. Subjects and methods: Forty women newly diagnosed with gestational diabetes at 24-28 weeks of pregnancy and 30 healthy pregnant women matched in age and gestational week were included in this cross-sectional study. Serum nesfatin-1 levels were analyzed using ELISA, and the relationship between nesfatin-1 and several metabolic parameters were assessed. Results: Serum nesfatin-1 levels were found to be lower in women with gestational diabetes compared to the pregnant women in the control sample (p = 0.020). Multiple linear regression analysis revealed that nesfatin-1 was lower in participants with gestational diabetes independently from gestational age, BMI, HOMA-IR, fasting plasma glucose, and age. In correlation analysis, the only variable that was found to have a statistically significant correlation with nesfatin-1 was gestational age (p = 0.015, r = 0.30). Conclusion: Lower nesfatin-1 levels in women with gestational diabetes compared to the control group at 24-28 weeks of gestation draws attention to nesfatin-1 levels in gestational diabetes and motivates further research in this area. Arch Endocrinol Metab. 2017;61(5):455-9

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Section: Introductionmentioning

confidence: 99%

Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes

Ademoglu¹,

Gorar

Keskin

et al. 2017

Arch. Endocrinol. Metab.

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“…However, although it was demonstrated that nesfatin-1 suppresses appetite via the regulation of NPY, CART and POMC, and that adiponectin regulates energy metabolism in association with NPY and POMC (6,7,20), the mechanisms underlying the changes in nesfatin-1 and adiponectin levels with advancing age have not been fully elucidated. The present study aimed to investigate the effects of aging on the plasma levels of nesfatin-1 and adiponectin.…”

Section: Introductionmentioning

confidence: 99%

Effects of aging on the plasma levels of nesfatin-1 and adiponectin

Nishida

Kaimoto

et al. 2013

Biomedical Reports

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Abstract. Gastric and adipose tissue secrete a number of hormones that are involved in energy metabolism. The biological functions of these hormones, including their effects on aging, are currently under investigation. Adiponectin was shown to be directly involved in appetite and the control of body weight. However, the effects of aging of nesfatin-1, an appetite-suppressing peptide that was recently identified, have not yet been fully elucidated. The aim of this study was to determine the effects of aging on the plasma levels of nesfatin-1 and adiponectin. Our results demonstrated no significant differences in the nesfatin-1 plasma levels among three age groups (2, 6 and 24 months) of female BALB̸c mice. The plasma nesfatin-1 levels̸visceral fat (VF) ratio in the 24-month-old mice was significantly lower compared to that in the 2-and 6-month-old mice. In addition, there were no significant differences in the plasma adiponectin levels among the three age groups. The plasma adiponectin levels̸VF ratio in the 24-month-old mice was significantly lower compared to that in the 2-and 6-month-old mice. In conclusion, there were no age-related changes in the plasma levels of nesfatin-1 and adiponectin, although the ratio of plasma levels of nesfatin-1 and adiponectin per VF was decreased with advancing age. Our results indicated that nesfatin-1 and adiponectin may be involved in controlling energy balance during aging.

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“…Nesfatin-1, a recently described anorexigenic and satiety peptide, is secreted by different parts of the central nervous system (predominantly in the hypophysis and hypothalamus) and peripheral tissue such as the gastric mucosa, adipose tissue, and pancreas beta cells (4,8,(28)(29)(30). Experimental studies have revealed that cerebroventricular and peripheral nesfatin-1 injection in rats inhibited food intake (9,31).…”

Section: Discussionmentioning

confidence: 99%

Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition

Acar¹,

Çatlı²,

Küme³

et al. 2018

Turk J Med Sci

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Background/aim: Nesfatin-1, an anorexigenic molecule, seems to play a role in appetite regulation and energy homeostasis. The goal of this study was to evaluate the relation of nesfatin-1 with anthropometric and metabolic (ghrelin, leptin) parameters in children with idiopathic chronic malnutrition. Materials and methods:The study included 37 underweight and 38 healthy children who were similar regarding age, sex, and pubertal status. Anthropometric and biochemical (nesfatin-1, ghrelin, and leptin levels) variables were assessed.Results: A total of 37 underweight subjects (mean age 10.5 ± 2.6 years) and 38 heathy subjects (mean age 10.3 ± 2.3 years) were recruited. Underweight children had significantly higher nesfatin-1 (2.76 ± 0.4 vs. 1.56 ± 0.7, P < 0.001) and lower leptin levels (2.21 ± 2.0 vs. 5.21 ± 2.4, P < 0.001) than those of the control subjects. Nesfatin-1 levels were significantly associated with only leptin levels, after adjusting for age and BMI (r = -0.371, P = 0.001). Conclusion:The present study is the first to evaluate nesfatin-1 levels in relation with anthropometric and metabolic parameters in children with chronic malnutrition, who were subsequently found to have significantly higher nesfatin-1 levels. Our study underlines that nesfatin-1 may play a role in the development of malnutrition by inhibiting food intake in children.

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Nesfatin-1 — Role as possible new potent regulator of food intake

Cited by 77 publications

References 44 publications

Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes

Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes

Effects of aging on the plasma levels of nesfatin-1 and adiponectin

Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition

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