Nesfatin-1 prevents negative changes in bone in conditions of developing osteopenia

Puzio, Iwona; Tymicki, Grzegorz; Pawłowska, Marta; Bieńko, Marek; Radzki, Radosław P.

doi:10.26444/aaem/105981

Cited by 5 publications

(14 citation statements)

References 75 publications

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“…Peterson et al [ 44 ] reported that NUCB exhibited intra- and extracellular localization within the bone tissue. Puzio et al [ 14 ] obtained similar results for cartilage of the distal metaphysis of the rat femur. The authors suggested that nesfatin-1 can act as a modulator of bone matrix maturation and possibly be of importance in Ca 2+ transport during bone formation [ 14 , 44 ].…”

Section: Resultsmentioning

confidence: 60%

“…Puzio et al [ 14 ] obtained similar results for cartilage of the distal metaphysis of the rat femur. The authors suggested that nesfatin-1 can act as a modulator of bone matrix maturation and possibly be of importance in Ca 2+ transport during bone formation [ 14 , 44 ]. The EDS qualitative analysis showed an increase in Ca 2+ content in the NES samples in relation to the OVX group, which could be related to an increase in the bone strength.…”

Section: Resultsmentioning

confidence: 60%

“…The most common disease affecting the mechanical properties of bones is osteoporosis. It is characterized by mass loss and microarchitectural disorders, leading to the weakening of the bone structure and resistance [ 14 , 15 ]. Osteoporosis is mainly caused by an imbalance between the osteoblast-mediated bone formation and the osteoclast-mediated bone resorption [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…As nesfatin-1 is a pleiotropic peptide naturally produced in the body, studying its effects on bone tissue can be very helpful in preventing and treating bone disorders. The results obtained by Puzio et al [ 14 ] showed that nesfatin-1 exerts a protective effect on the bone tissue properties in rats in the conditions of developing osteopenia. The authors showed an increase in the femur mechanical parameters of ovariectomized rats receiving nesfatin-1 under the quasi-static loading condition [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…The results obtained by Puzio et al [ 14 ] showed that nesfatin-1 exerts a protective effect on the bone tissue properties in rats in the conditions of developing osteopenia. The authors showed an increase in the femur mechanical parameters of ovariectomized rats receiving nesfatin-1 under the quasi-static loading condition [ 14 ]. These results indicate that nesfatin-1 can be used in the prevention of bone loss that leads to a reduction in bone strength.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Nesfatin-1 on Rat Humerus Mechanical Properties under Quasi-Static and Impact Loading Conditions

et al. 2022

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The investigations on the response of bone tissue under different loading conditions are important from clinical and engineering points of view. In this paper, the influence of nesfatin-1 administration on rat humerus mechanical properties was analyzed. The classical three-point bending and impact tests were carried out for three rat bone groups: control (SHO), the humerus of animals under the conditions of established osteopenia (OVX), and bones of rats receiving nesfatin-1 after ovariectomy (NES). The experiments proved that the bone strength parameters measured under various mechanical loading conditions increased after the nesfatin-1 administration. The OVX bones were most susceptible to deformation and had the smallest fracture toughness. The SEM images of humerus fracture surface in this group showed that ovariectomized rats had a much looser bone structure compared to the SHO and NES females. Loosening of the bone structure was also confirmed by the densitometric and qualitative EDS analysis, showing a decrease in the OVX bones’ mineral content. The samples of the NES group were characterized by the largest values of maximum force obtained under both quasi-static and impact conditions. The energies absorbed during the impact and the critical energy for fracture (from the three-point bending test) were similar for the SHO and NES groups. Statistically significant differences were observed between the mean Fi max values of all analyzed sample groups. The obtained results suggest that the impact test was more sensitive than the classical quasi-static three-point bending one. Hence, Fi max could be used as a parameter to predict bone fracture toughness.

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Section: Resultsmentioning

confidence: 60%

Section: Resultsmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Nesfatin-1 on Rat Humerus Mechanical Properties under Quasi-Static and Impact Loading Conditions

et al. 2022

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Lipoic acid (LA) dose-dependently protects bone losses in the mandible of rats during the development of osteopenia by inhibiting oxidative stress and promoting bone formation

Radzki

Bieńko

Wolski

et al. 2022

Biomedicine & Pharmacotherapy

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The role of adipokines in osteoporosis management: a mini review

Patil,

Fredericks

2024

Front. Endocrinol.

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The prevalence of osteoporosis has been on the rise globally. With ageing populations, research has sought therapeutic solutions in novel areas. One such area is that of the adipokines. Current literature points to an important role for these chemical mediators in relation to bone metabolism. Well-established adipokines have been broadly reported upon. These include adiponectin and leptin. However, other novel adipokines such as visfatin, nesfatin-1, meteorin-like protein (Metrnl), apelin and lipocalin-2 are starting to be addressed pre-clinically and clinically. Adipokines hold pro-inflammatory and anti-inflammatory properties that influence the pathophysiology of various bone diseases. Omentin-1 and vaspin, two novel adipokines, share cardioprotective effects and play essential roles in bone metabolism. Studies have reported bone-protective effects of omentin-1, whilst others report negative associations between omentin-1 and bone mineral density. Lipocalin-2 is linked to poor bone microarchitecture in mice and is even suggested to mediate osteoporosis development from prolonged disuse. Nesfatin-1, an anorexigenic adipokine, has been known to preserve bone density. Animal studies have demonstrated that nesfatin-1 treatment limits bone loss and increases bone strength, suggesting exogenous use as a potential treatment for osteopenic disorders. Pre-clinical studies have shown adipokine apelin to have a role in bone metabolism, mediated by the enhancement of osteoblast genesis and the inhibition of programmed cell death. Although many investigations have reported conflicting findings, sufficient literature supports the notion that adipokines have a significant influence on the metabolism of bone. This review aims at highlighting the role of novel adipokines in osteoporosis while also discussing their potential for treating osteoporosis.

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Nesfatin-1 prevents negative changes in bone in conditions of developing osteopenia

Cited by 5 publications

References 75 publications

Effect of Nesfatin-1 on Rat Humerus Mechanical Properties under Quasi-Static and Impact Loading Conditions

Effect of Nesfatin-1 on Rat Humerus Mechanical Properties under Quasi-Static and Impact Loading Conditions

Lipoic acid (LA) dose-dependently protects bone losses in the mandible of rats during the development of osteopenia by inhibiting oxidative stress and promoting bone formation

The role of adipokines in osteoporosis management: a mini review

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