2015
DOI: 10.3109/09513590.2015.1024219
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Nesfatin-1 levels and metabolic markers in polycystic ovary syndrome

Abstract: Nesfatin-1 is a novel hormone synthesized in hypothalamus and several other specific organs to regulate eating habits, appetite and is thought to be related to ovarian functions. In our study, we aimed to evaluate the nesfatin-1 levels with other metabolic parameters in polycystic ovary syndrome (PCOS), a condition that is known to be related to both ovarian functions and obesity. Study subjects were chosen from the women attended to the Obstetrics and Gynecology Department of Istanbul Bilim University, Avrupa… Show more

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Cited by 23 publications
(20 citation statements)
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“…Several studies revealed that hyperglycemia, IR and Hyperlipidemia cause endothelial dysfunction and leading to atherosclerosis. ( 23,24) This study shows that IR, FPS, LDL and TG, have a strong positive association with an elevated concentration of Nesfatin-1, strictly those with IR and obesity, and the controversial data of this study confirm the above and agree with other researches (25,26,8) and disagree with others (27,5,20) According to BMI cut-off value of 30 Kg/m 2 the results of subgroups of both PCOS and controls revealed that nesfatin-1 concentration in both obese PCOS (n=23) (11.3±4.2 ng/ml) and non-obese PCOS subgroup (n=22) (8.5±1.2 ng/ml) were higher than their levels in the obese control (n=21) (7.2±2.2 ng/ml) and non-obese control subgroup (n=19)(5.1±2.4 ng/ml).…”
Section: Discussionsupporting
confidence: 78%
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“…Several studies revealed that hyperglycemia, IR and Hyperlipidemia cause endothelial dysfunction and leading to atherosclerosis. ( 23,24) This study shows that IR, FPS, LDL and TG, have a strong positive association with an elevated concentration of Nesfatin-1, strictly those with IR and obesity, and the controversial data of this study confirm the above and agree with other researches (25,26,8) and disagree with others (27,5,20) According to BMI cut-off value of 30 Kg/m 2 the results of subgroups of both PCOS and controls revealed that nesfatin-1 concentration in both obese PCOS (n=23) (11.3±4.2 ng/ml) and non-obese PCOS subgroup (n=22) (8.5±1.2 ng/ml) were higher than their levels in the obese control (n=21) (7.2±2.2 ng/ml) and non-obese control subgroup (n=19)(5.1±2.4 ng/ml).…”
Section: Discussionsupporting
confidence: 78%
“…About 5-10% of young women is affected by PCOS, which represent the usual cause of female infertility. The major number of the women with PCOS are either overweight or obese (4,5,6) , which may enhance androgen secretion, while diminishing the metabolism reproductive functions with possibly favouring the development of PCOS phenotype (7) .…”
Section: Introductionmentioning
confidence: 99%
“…Nesfatin-1 has been shown to increase glucose-induced insulin secretion in pancreatic β cells by increasing Ca 2+ flow through L-type channels in mice ( 10 ) . Furthermore, nesfatin-1 also has an anorexigenic effect by lessening the number of meals and extending the interval between meals ( 11 ) . Due to these metabolic properties, levels of nesfatin-1 were assessed in PCOS, which frequently co-exists with obesity and IR, and it was determined to be lower in some studies ( 11 , 12 , 13 ) , whereas it was determined to be higher in others ( 9 , 14 , 15 ) .…”
Section: Introductionmentioning
confidence: 99%
“…In the present literature, two studies report an increased circulating level of nesfatin-1 peptide in patients suffering from PCOS compared to controls [245,253], with strong positive correlations between nesfatin-1 and BMI and HOMA-IR [245,253]. In contrast, in two other studies decreased circulating nesfatin-1 peptide was observed in patients with PCOS with no or a negative correlation to BMI and HOMA-IR [254,255]. Altogether, inconsistent results clearly suggest the need for further investigation.…”
Section: Plasma and Serummentioning
confidence: 57%
“…Nesfatin-1 may play a role in fertility and pregnancy-related disorders, but current data is inconsistent. Regarding PCOS, some studies found increased circulating levels of nesfatin-1 peptide in patients suffering from PCOS compared to controls [245,253], while in others decreased circulating nesfatin-1 protein were shown in patients with PCOS [254,255]. Similarly, results from examinations of HG are contradicting; however, careful matching showed that nesfatin-1 peptide blood concentration increased in patients with HG compared to controls [211].…”
Section: Nesfatin's Role In Reproduction-related Health Conditionsmentioning
confidence: 99%