Objective: to evaluate the nesfatin-1 levels in addition to other metabolic components in polycystic ovary syndrome PCOS in a state that to be associated with both functions of ovary and obesity.
Methods:A cross-section observational study was carried on total of forty-five (45) women in the reproductive age with polycystic ovary syndrome (23 obese, 22 non-obese) attending Infertility unit and outpatients clinic of Gynecology and Obstetrics at AL-Yarmouk Teaching Hospital, in addition to forty (40) (30 obese, 10 non-obese) age matched healthy individuals. Serum nesfatin-1, TC, TG, HDL-C, FPG, FPI, E 2 , TT, LH, FSH and Prol were measured, in addition to HOMA-IR, BMI and LDL-C was calculated.Results: FPG (5.1±0.3 mmol/L), HOMA-IR (2.8±1.1) were significantly higher in PCOS group than their results in the control group (4.8±0.2 mmol/L), (2.2±1.3) (P ˂ 0.05, 0.01) respectively. Nesfatin-1 level (11.1±3.5 ng/ml), TT (1.7±0.3 pg/ml) and LH (6.5±2.8 mIU/ml) in PCOS group were significantly difference (P ˂ 0.001, 0.05) respectively, when compared their concentration in the control group (6.3±3.0 ng/ml), (0.9±o.1 pg/ml), (4.9±1.5 mIU/ml). Among the patients with PCOS, a strong positive correlation were found between nesfatin-1 and WC (r=0.