Nesfatin-1 and visfatin expression is associated with reduced atherosclerotic disease risk in patients with rheumatoid arthritis

Estimation of Serum Chemerin, Visfatin Levels and Their Ratio as A Possible Diagnostic Parameters of Rheumatoid Arthritis

“…59 There were a few studies about the effect of adipokine visfatin in RA which indicate a positive correlation between visfatin and inflammation markers, and elevated levels in RA patients when compared with control subjects. 60,61 A significant increase of other parameters in the present study is in agreement with many studies deals with RA patients. 62,63 The results also indicate a significant difference between RA patients and the control groups in Chemerin/Visfatin ratio.…”

“…64 Other studies have shown associations between visfatin and other inflammatory markers. [58][59][60][61][62][63][64][65] In this study, another relationship was found between chemerin with CRP and UA, indicated a relationship with systemic inflammation. 66 The inflammatory cytokines released by adipose tissue stimulate the synthesis of CRP in the liver, which was observed in inflamed tissues, in RA and in myocardium after infarction.…”

Current Understanding of the Role of Nesfatin-1

“…Whether this discrepancy is caused by dosage differences (1 µM vs. 100 pM/L) warrants further investigation. Lastly, in a human study investigating subjects with rheumatoid arthritis, nesfatin-1 correlated positively with rheumatoid factor, matrix metalloproteinase-2, and plaque stability mediator and negatively with carotid intima-media thickness [ 153 ], giving rise to a protective effect of nesfatin-1 under these conditions.…”

Nesfatin-1/Nucleobindin-2 Is a Potent Prognostic Marker and Enhances Cell Proliferation, Migration, and Invasion in Bladder Cancer

“…NUCB2 has some functional domains, such as signal peptide, Leu/Ile-rich region [ 11 ], two Ca 2+ -binding EF-hand domains [ 12 ], and leucine zipper [ 13 ]. NUCB2 is expressed in many tissues and performed a variety of physiological functions, such as anti-inflammation [ 14 , 15 ], reducing cardiovascular risk [ 16 , 17 ] and atherosclerosis extent [ 18 ]. Recently, NUCB2 has also been declared to play a role in proliferation, invasion, and migration in tumor cells and to affect the prognosis of tumor patients [ 19 ].…”