Nervonic acid level in cerebrospinal fluid is a candidate biomarker for depressive and manic symptoms: A pilot study

Kageyama, Yuki; Deguchi, Yasuhiko; Hattori, Kotaro; Yoshida, Sumiko; Goto, Yu‐ichi; Inoue, Koki; Kato, Takeshi

doi:10.1002/brb3.2075

Cited by 18 publications

(12 citation statements)

References 34 publications

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“…Some scholars even found that some biomarkers of renal insufficiency can be referenced to predict the depressive and anxious status in SLE patients, despite that they fail to show value in diagnosis of nephritis (46). The levels of nervonic acid in plasma and cerebrospinal fluid were a satisfied biomarker for forecasting depressive symptoms (47,48). In light of this, nervonic acid is not only associated with the renal impairment in SLE patients, but also correlated with the depressive state.…”

Section: A B Cmentioning

confidence: 97%

Metabolic profiling reveals new serum signatures to discriminate lupus nephritis from systemic lupus erythematosus

et al. 2022

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BackgroundLupus nephritis (LN) occurs in 50% of patients with systemic lupus erythematosus (SLE), causing considerable morbidity and even mortality. Previous studies had shown the potential of metabolic profiling in the diagnosis of SLE or LN. However, few metabonomics studies have attempted to distinguish SLE from LN based on metabolic changes. The current study was designed to find new candidate serum signatures that could differentiate LN from SLE patients using a non-targeted metabonomics method based on ultra high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS).MethodMetabolic profiling of sera obtained from 21 healthy controls, 52 SLE patients and 43 LN patients. We used SPSS 25.0 for statistical analysis. Principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA) and metabolic pathway analysis were used to analyze the metabolic data.ResultsUpon comparison of SLE and LN groups, 28 differential metabolites were detected, the majority of which were lipids and amino acids. Glycerolphospholipid metabolism, pentose and glucuronate interconversions and porphyrin and chlorophyll metabolism were obviously enriched in LN patients versus those with SLE. Among the 28 characteristic metabolites, five key serum metabolites including SM d34:2, DG (18:3(9Z,12Z,15Z)/20:5(5Z,8Z,11Z,14Z,17Z)/0:0), nervonic acid, Cer-NS d27:4, and PC (18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z) performed higher diagnostic performance in discriminating LN from SLE (all AUC > 0.75). Moreover, combined analysis of neuritic acid, C1q, and CysC (AUC = 0.916) produced the best combined diagnosis.ConclusionThis study identified five serum metabolites that are potential indicators for the differential diagnosis of SLE and LN. Glycerolphospholipid metabolism may play an important role in the development of SLE to LN. The metabolites we screened can provide more references for the diagnosis of LN and more support for the pathophysiological study of SLE progressed to LN.

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Section: A B Cmentioning

confidence: 97%

Metabolic profiling reveals new serum signatures to discriminate lupus nephritis from systemic lupus erythematosus

et al. 2022

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“…Both healthy and unhealthy workers were concurrently recruited and analyzed in the present study. Objective assessments of participants with current psychiatric treatment and psychiatric history were not conducted, which could be a limitation [ 34 , 35 ]. Finally, the influence of memory bias could not be corrected, because self-administered scales were utilized in this research.…”

Section: Discussionmentioning

confidence: 99%

Cognitive complaints mediate childhood parental bonding influence on presenteeism

et al. 2022

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Background Childhood parental bonding and cognitive complaints (CCs) affect a worker’s mental health (MH), and CCs affect presenteeism. However, the impact of childhood parental bonding on presenteeism and the mediating effect of CCs with respect to the association among childhood parental bonding and presenteeism remain poorly understood. Aim We aimed to investigate the mediating role of CCs on the relationship between childhood parental bonding and presenteeism to better understand the influence of childhood parental bonding on adulthood presenteeism. Setting A total of 440 Japanese adult workers recruited using convenience sampling were evaluated. Methods The Parental Bonding Instrument, Cognitive Complaints in Bipolar Disorder Rating Assessment and Work Limitations Questionnaire 8 were used to assess childhood parental bonding, CCs, and presenteeism, respectively. We performed Spearman’s correlation analysis and path analysis to investigate the relationship among the variables. Results Path analysis revealed that childhood parental bonding and CCs significantly affected presenteeism. More specifically, CCs fully and partially mediated the effect of paternal and maternal care on presenteeism, respectively. Moreover, CCs partially mediated the effects of both paternal and maternal overprotection on presenteeism. Conclusion The mediating role of CCs on the relationship between childhood parental bonding and presenteeism was shown in this study. In occupational MH, evaluating the mediating effect of CCs may be useful for addressing adulthood presenteeism associated with childhood parental bonding.

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“…Additionally, valeric acid was also found to be reduced in MDD patients, which could be explained by dysregulation of the brain-gut-microbiota axis or increased N-methyl-d-aspartate (NMDA) receptor activity [ 46 ]. On the other hand, nervonic acid, a monounsaturated fatty acid important for myelin synthesis, has been elevated in patients with MDD [ 26 ] but cerebrospinal fluid nervous acid levels did not differ between MDD patients and healthy controls [ 53 ].…”

Section: Reviewmentioning

confidence: 99%

Metabolomics of Major Depressive Disorder: A Systematic Review of Clinical Studies

Costa¹,

Carneiro²,

Alves³

et al. 2022

Cureus

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Although the understanding of the pathophysiology of major depressive disorder (MDD) has advanced greatly, this has not been translated into improved outcomes. To date, no biomarkers have been identified for the diagnosis, prognosis, and therapeutic management of MDD. Thus, we aim to review the biomarkers that are differentially expressed in MDD. A systematic review was conducted in January 2022 in the PubMed/MEDLINE, Scopus, Embase, PsycINFO, and Gale Academic OneFile databases for clinical studies published from January 2001 onward using the following terms: "Depression" OR "Depressive disorder" AND "Metabolomic." Multiple metabolites were found at altered levels in MDD, demonstrating the involvement of cellular signaling metabolites, components of the cell membrane, neurotransmitters, inflammatory and immunological mediators, hormone activators and precursors, and sleep controllers. Kynurenine and acylcarnitine were identified as consistent with depression and response to treatment. The most consistent evidence found was regarding kynurenine and acylcarnitine. Although the data obtained allow us to identify how metabolic pathways are affected in MDD, there is still not enough evidence to propose changes to current diagnostic and therapeutic actions. Some limitations are the heterogeneity of studies on metabolites, methods for detection, analyzed body fluids, and treatments used. The experiments contemplated in the review identified increased or reduced levels of metabolites, but not necessarily increased or reduced the activity of the associated pathways. The information acquired through metabolomic analyses does not specify whether the changes identified in the metabolites are a cause or a consequence of the pathology.

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Nervonic acid level in cerebrospinal fluid is a candidate biomarker for depressive and manic symptoms: A pilot study

Cited by 18 publications

References 34 publications

Metabolic profiling reveals new serum signatures to discriminate lupus nephritis from systemic lupus erythematosus

Metabolic profiling reveals new serum signatures to discriminate lupus nephritis from systemic lupus erythematosus

Cognitive complaints mediate childhood parental bonding influence on presenteeism

Metabolomics of Major Depressive Disorder: A Systematic Review of Clinical Studies

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