Neural network-based automated analyses of nSp recordings provide accurate identification of OSA severity among habitually snoring children with a high pretest probability of OSA. Thus, nocturnal oximetry may enable a simple and effective diagnostic alternative to nocturnal polysomnography, leading to more timely interventions and potentially improved outcomes.
Our study investigates the clinical phenotypes and outcomes of patients with antisynthetase syndrome with distinct antisynthetase antibodies and highlights the link between the anti-PL7 antibody and RP-ILD.
Background: Cancer is a significant complication contributing to increased mortality in idiopathic inflammatory myopathies (IIMs), and the association between IIMs and cancer has been extensively reported. Myositis-specific autoantibodies (MSAs) can help to stratify patients into more homogeneous groups and may be used as a biomarker for cancer-associated myositis. In this study, we aimed to systematically define the cancer-associated MSAs in IIMs. Methods: Serum from 627 patients with IIMs was tested for MSAs. The cancer risk with different MSAs was estimated by standardized incidence ratio (SIR). Paraneoplastic manifestation, such as the close temporal relationship between myositis onset and cancer diagnoses in patients with different MSAs, was also evaluated. Results: Compared with the general Chinese population, patients with IIMs and anti-transcriptional intermediary factor (TIF1)-γ antibodies (SIR = 17.28, 95% CI 11.94 to 24.14), anti-nuclear matrix protein (NXP2) antibodies (SIR = 8.14, 95% CI 1.63 to 23.86), or anti-SAE1 antibodies (SIR = 12.92, 95% CI 3.23 to 32.94), or who were MSAs-negative (SIR = 3.99, 95% CI 1.96 to 7.14) faced increased risk of cancer. There was no association between specific MSAs subtypes and certain types of cancer. Paraneoplastic manifestations were observed in the patients carrying anti-TIF1-γ, as well as other MSAs. There were no prognostic differences among the patients with cancer-associated myositis (CAM) from different MSAs subgroups. However, in comparison to those with cancer unrelated to myositis, CAM had a worse prognosis, with an age-adjusted and sex-adjusted Cox hazard ratio (HR) of 10.8 (95% CI 1.38-84.5, p = 0.02) for all-cause mortality.
A novel microwave photonic phase shifter based on a single-sideband (SSB) polarization modulator (PolM) and a polarizer is proposed and demonstrated. In the SSB-PolM, two SSB intensity-modulated signals with a phase difference of π along two orthogonal polarization directions are generated. With the polarizer to combine the two signals, the phase of the optical microwave signal can be tuned from -180 to 180 deg by simply adjusting the polarization direction of the polarizer, whereas the amplitude keeps unchanged. An experiment is carried out. A full-range tunable phase shift in the frequency range of 11-43 GHz is achieved. The flat power response, power independent operation, and high stability of the proposed microwave photonic phase shifter is also confirmed.
The prevalence of AR in young children can be overestimated using epidemiologic criteria. AR is a common disease in Asian preschool children, with an increasing trend as children get older, and is higher in urban than suburban areas--suggesting an important role for environmental risk factors in AR.
As the only method for all-weather, all-time and longdistance target detection and recognition, radar has been intensively studied since it was invented, and is considered as an essential sensor for future intelligent society. In the past few decades, great efforts were devoted to improving radar's functionality, precision, and response time, of which the key is to generate, control and process a wideband signal with high speed. Thanks to the broad bandwidth, flat response, low loss transmission, multidimensional multiplexing, ultrafast analog signal processing and electromagnetic interference immunity provided by modern photonics, implementation of the radar in the optical domain can achieve better performance in terms of resolution, coverage, and speed which would be difficult (if not impossible) to implement using traditional, even state-of-the-art electronics. In this tutorial, we overview the distinct features of microwave photonics and some key microwave photonic technologies that are currently known to be attractive for radars. System architectures and their performance that may interest the radar society are emphasized. Emerging technologies in this area and possible future research directions are discussed.
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