Nerve Regeneration and Bioengineering

Sedaghati, Tina; Jell, Gavin; Seifalian, Alexander M.

doi:10.1016/b978-0-12-398523-1.00057-4

Cited by 14 publications

(8 citation statements)

References 87 publications

(68 reference statements)

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“…The peripheral neurons show a good regeneration potential after injury [5], allowing the application of direct nerve repair and joining both ends of a sectioned peripheral nerve with epineural micro-sutures to treat PNI. However, this surgical procedure is limited to injuries showing distal to proximal nerve gaps smaller than eight millimeters [6]. For larger gaps, where a direct join of both nerve stumps is not possible, grafting is the alternative, with the autograft as the preferred choice [7,8].…”

Section: Introductionmentioning

confidence: 99%

UV-Casting on Methacrylated PCL for the Production of a Peripheral Nerve Implant Containing an Array of Porous Aligned Microchannels

et al. 2020

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Peripheral nerves are basic communication structures guiding motor and sensory information from the central nervous system to receptor units. Severed peripheral nerve injuries represent a large clinical problem with relevant challenges to successful synthetic nerve repair scaffolds as substitutes to autologous nerve grafting. Numerous studies reported the use of hollow tubes made of synthetic polymers sutured between severed nerve stumps to promote nerve regeneration while providing protection for external factors, such as scar tissue formation and inflammation. Few approaches have described the potential use of a lumen structure comprised of microchannels or microfibers to provide axon growth avoiding misdirection and fostering proper healing. Here, we report the use of a 3D porous microchannel-based structure made of a photocurable methacrylated polycaprolactone, whose mechanical properties are comparable to native nerves. The neuro-regenerative properties of the polymer were assessed in vitro, prior to the implantation of the 3D porous structure, in a 6-mm rat sciatic nerve gap injury. The manufactured implants were biocompatible and able to be resorbed by the host’s body at a suitable rate, allowing the complete healing of the nerve. The innovative design of the highly porous structure with the axon guiding microchannels, along with the observation of myelinated axons and Schwann cells in the in vivo tests, led to a significant progress towards the standardized use of synthetic 3D multichannel-based structures in peripheral nerve surgery.

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Section: Introductionmentioning

confidence: 99%

UV-Casting on Methacrylated PCL for the Production of a Peripheral Nerve Implant Containing an Array of Porous Aligned Microchannels

et al. 2020

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“…As extensively demonstrated by in vitro studies and tissue engineering strategies, axonal regrowth and guidance are enhanced by ECM components, including collagen IV or laminin 16‐20 . In agreement with this, decell scaffolds prepared from nervous system‐derived tissues (including decell nerves) have been proved to support long‐distance axon regeneration in peripheral nerve injury in animal models 21‐24 as well as in patients 25‐27 …”

Section: Introductionmentioning

confidence: 73%

Decellularized skeletal muscles display neurotrophic effects in three-dimensional organotypic cultures

Raffa

Scattolini

Gerli

et al. 2020

Stem Cells Translational Medicine

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“…The uneven external surface of samples CH HA SWCN 3, CH HA SWCN 4, CH HA MWCN 3, and CH HA MWCN 4 excluded them from further analysis as the recent studies have shown that implants with sharp borders induce the granulomatous inflammatory response (Sedaghati et al, 2014); and therefore they are not appropriate for in vivo implantation.…”

Section: Resultsmentioning

confidence: 99%

Tubular electrodeposition of chitosan–carbon nanotube implants enriched with calcium ions

Nawrotek

Tylman

Rudnicka

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Nerve Regeneration and Bioengineering

Cited by 14 publications

References 87 publications

UV-Casting on Methacrylated PCL for the Production of a Peripheral Nerve Implant Containing an Array of Porous Aligned Microchannels

UV-Casting on Methacrylated PCL for the Production of a Peripheral Nerve Implant Containing an Array of Porous Aligned Microchannels

Decellularized skeletal muscles display neurotrophic effects in three-dimensional organotypic cultures

Tubular electrodeposition of chitosan–carbon nanotube implants enriched with calcium ions

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