Nerve growth factor‐induced circadian phase shifts and MAP kinase activation in the hamster suprachiasmatic nuclei

Pizzio, Gastón A.; Hainich, Ernesto C.; Plano, Santiago Andrés; Ralph, Martin R.; Golombék, Diego A.

doi:10.1111/j.1460-9568.2005.04247.x

Cited by 14 publications

(15 citation statements)

References 36 publications

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“…In one study of acute jet lag, a single, 8-hr phase shift increased BDNF levels in the hippocampus [74]. Likewise, intracerebroventricular injections of NGF phase shift activity rhythms of Syrian hamsters [75] and increase survival of new cells [73]. Whereas both acute treatments increased these neurotrophic factors, it is possible that more chronic circadian disruptions suppress their expression.…”

Section: Discussionmentioning

confidence: 99%

Experimental ‘Jet Lag’ Inhibits Adult Neurogenesis and Produces Long-Term Cognitive Deficits in Female Hamsters

et al. 2010

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BackgroundCircadian disruptions through frequent transmeridian travel, rotating shift work, and poor sleep hygiene are associated with an array of physical and mental health maladies, including marked deficits in human cognitive function. Despite anecdotal and correlational reports suggesting a negative impact of circadian disruptions on brain function, this possibility has not been experimentally examined.Methodology/Principal FindingsIn the present study, we investigated whether experimental ‘jet lag’ (i.e., phase advances of the light∶dark cycle) negatively impacts learning and memory and whether any deficits observed are associated with reductions in hippocampal cell proliferation and neurogenesis. Because insults to circadian timing alter circulating glucocorticoid and sex steroid concentrations, both of which influence neurogenesis and learning/memory, we assessed the contribution of these endocrine factors to any observed alterations. Circadian disruption resulted in pronounced deficits in learning and memory paralleled by marked reductions in hippocampal cell proliferation and neurogenesis. Significantly, deficits in hippocampal-dependent learning and memory were not only seen during the period of the circadian disruption, but also persisted well after the cessation of jet lag, suggesting long-lasting negative consequences on brain function.Conclusions/SignificanceTogether, these findings support the view that circadian disruptions suppress hippocampal neurogenesis via a glucocorticoid-independent mechanism, imposing pronounced and persistent impairments on learning and memory.

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Section: Discussionmentioning

confidence: 99%

Experimental ‘Jet Lag’ Inhibits Adult Neurogenesis and Produces Long-Term Cognitive Deficits in Female Hamsters

et al. 2010

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“…Through this receptor, DPV576 activates keratinocytes, which downregulates the ion channel transient receptor potential vanilloid 4 (TRPV4) and an increases the secretion of nerve growth factor (NGF) [15]. Vanilloid-like channels are linked with circadian body temperature regulation and the autonomous nervous system [16], whereas NGF plays a major role in the regulation of circadian rhythms [17]. The second effect of DPV576-C is a temperature-regulating effect, which is caused by the far-infrared radiation of the ND and NP [18].…”

Section: Introductionmentioning

confidence: 99%

Influence of platinum harmonized textile on neuromuscular, systemic and subjective recovery

2017

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The clothing manufacturer Venex Life-Science tracks the strategy to enhance recovery process through implementing platinum harmonized technology (PHT) into their Venex® Regeneration Wear. The proposed mechanisms of the regeneration wear are an increase of parasympathetic activity and an increase of the temperature due far-infrared radiation. The purpose of this study was to investigate potential effects of Venex regeneration wear on the recovery of neuromuscular, systemic and subjective parameters following exercise. In a randomized, single-blinded cross-over design, 13 strength-trained male participants performed two exercise sessions in one day. After the first exercise session and for 3 nights following the exercise day participants wore the Venex regeneration wear or a placebo product. Measures of isometric maximum voluntary contraction (MVC), voluntary activation (VA) and potentiated twitch torque (PTT) of the knee extensors, as well as maximum jump height during the Counter-Movement and Drop Jump, creatinkinase (CK) and subjective parameters (perceived pain, recovery condition and sleep quality) were obtained before and after each exercise session and 24, 48, and 72 hours after the first exercise session. MVC, PTT, CK and jump parameters changed over time during the exercise day as well as on the following days, however, there were no significant differences between treatments. Subjective parameters showed strong effect sizes (i. e. Cohen’s d > 0.6) in favor for Venex but no significant differences between treatments. Based on these findings, it is concluded that wearing a platinum harmonized textile following exercise did not improve neuromuscular and systemic recovery in a trained male population to a statistical noticeable extent. However, the findings for the subjective parameters suggest some potential for enhanced recovery that requires further research.

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“…MAPK signaling pathways play important roles in light-induced gene expression and light entrainment of the circadian clock in mammals (Coogan and Piggins 2004;Dziema et al 2003). p38 MAPK is rhythmic and light responsive in the SCN and is modulated by light and other extracellular signals, such as NGF, EGF, GRP, similarly to other MAP kinases (Antle et al 2005;Coogan and Piggins 2004;Pizzio et al 2003Pizzio et al , 2005. PACAP has also been shown to be a potent activator of the MAPK pathway in SCN Figure 2 Appearance of 14-3-3 during 24 h in control chicken pineal cells and in cells treated with 1 nM PACAP (a), 10 nM PACAP (b), or 100 nM PACAP (c).…”

Section: Discussionmentioning

confidence: 99%

Effects of PACAP on the Circadian Changes of Signaling Pathways in Chicken Pinealocytes

et al. 2008

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Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in the regulation of circadian rhythms. In mammals, the brain's biological clock is the suprachiasmatic nucleus, receiving photic information from the retina through the retinohypothalamic pathway, where PACAP is the main cotransmitter of glutamate. The primary conductor of circadian rhythms of birds is the pineal gland. The presence of PACAP has been demonstrated both in the rat and avian pineal gland, where PACAP stimulates melatonin synthesis. The signaling mechanism, by which PACAP modulates melatonin synthesis and circadian rhythmic functions of the pineal gland, is only partially known. The aim of the present study was to investigate the effects of PACAP on the changes of p38 mitogen-activated protein kinase (MAPK) and 14-3-3 protein in chick pineal cell culture both of which have been shown to participate in the regulation of rhythmic functions. Pineal cells were treated with 1, 10, or 100 nM PACAP38 every 4 h during a 24-h period. The phosphorylation of p38 MAPK showed obvious changes during the observed 24 h, while the level of 14-3-3 protein did not. We found that the lowest used dose of PACAP did not cause any phase alteration in p38 MAPK phosphorylation. Ten nM PACAP induced a 4-h-long delay and 100 nM abolished the circadian changes of p38 MAPK phosphorylation. PACAP was not effective on the level of 14-3-3 protein in the early morning hours, and only the highest tested dose (100 nM) could evoke a change in the appearance of 14-3-3 between midday and midnight hours. In summary, PACAP modulated the phosphorylation of p38 MAPK and the appearance of 14-3-3 protein in the chicken pineal cells, but these effects were dose dependent and also depended on the time of day.

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Nerve growth factor‐induced circadian phase shifts and MAP kinase activation in the hamster suprachiasmatic nuclei

Cited by 14 publications

References 36 publications

Experimental ‘Jet Lag’ Inhibits Adult Neurogenesis and Produces Long-Term Cognitive Deficits in Female Hamsters

Experimental ‘Jet Lag’ Inhibits Adult Neurogenesis and Produces Long-Term Cognitive Deficits in Female Hamsters

Influence of platinum harmonized textile on neuromuscular, systemic and subjective recovery

Effects of PACAP on the Circadian Changes of Signaling Pathways in Chicken Pinealocytes

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