Nerve growth factor as an important possible component of novel therapy for cancer, diabetes and cardiovascular diseases

Steckiewicz, Karol P; Barcińska, Ewelina; Woźniak, Michał

doi:10.14715/cmb/2018.64.9.3

Cited by 5 publications

(2 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increasing evidence suggest that in addition to their neurotrophic functions, proNGF and NGF participate in several biological processes, including the immune response, inflammatory response, pulmonary hypertension, wound healing and cancer metastasis ( 23 , 33 , 36-42 ). Studies on NGF and its receptors have identified novel therapeutic approaches for malignant tumors, diabetes, chronic wounds and cardiovascular diseases ( 13 , 40 ).…”

Section: Biology Of Ngf and Its Receptorsmentioning

confidence: 99%

Role of NGF and its receptors in wound healing (Review)

Liu

Huang

2021

Exp Ther Med

View full text Add to dashboard Cite

Wound healing is an important and complicated process that includes four highly integrated and overlapping phases, haemostasis, inflammation, proliferation and tissue remodelling. Nerve growth factor (NGF) was the first member of a family of neurotrophic factors to be discovered, and is an essential neurotrophic factor for the development and maintenance of the central and peripheral nervous systems. Several studies have proposed that NGF and its receptors, tropomyosin-related kinase receptor 1 and NGF receptor, are involved in the wound healing process, and are important components of the healing of several wounds both in vivo and in vitro . Topical application of NGF significantly promotes the healing of different types of wounds, including diabetic foot ulcers, pressure ulcers and corneal wounds. The present review summarizes the status of NGF and its receptors in current literature, and discusses data obtained in the last few years on the healing action of NGF in cutaneous, corneal and oral wounds.

show abstract

Section: Biology Of Ngf and Its Receptorsmentioning

confidence: 99%

Role of NGF and its receptors in wound healing (Review)

Liu

Huang

2021

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Neurotrophins including nerve growth factor (NGF) family and brain derived neurotrophic factor (BDNF) are small polypeptides with potent effects on health and well-being of the neuronal and non-neuronal cells. 4 , 5 Recently, NGF and BDNF as adipokines are taken into consideration due to their possible roles in some metabolic disorders such as diabetes mellitus 6 , 7 , atherosclerosis 8 and metabolic syndrome (MetS). 9 Despite the contradictory results 10 , the growing body of evidence suggests that low levels of circulating BDNF and NGF were significantly associated with high body mass index (BMI), hemoglobin A1C (HbA1C) and hypertriglyceridemia.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis

Zeinalian

Moghadam

Pahlavani

et al. 2022

J Cardiovasc Thorac Res

View full text Add to dashboard Cite

Introduction: Although, some evidence has shown that obestatin, ghrelin, and neurotrophic factors can be involved in the development of cardio-metabolic risk factors, there are some contradictions in this regard. We aimed to investigate the association of serum neurotrophic factors and some gastric hormones with cardio-metabolic risk factors among apparently healthy women. Methods: In the present study, 90 apparently healthy women were recruited by a convenient sampling method from the nutrition counseling clinic in Tabriz, Iran. All participants need dietary counseling for weight loss and were recruited before receiving any dietary interventions. Anthropometric, biochemical, physical activity, and blood pressure (BP) measurements, as well as dietary assessment, were done in all participants. Results: Women who were in the highest tertile of serum obestatin levels (OR=0.118, 95% CI:0.035-0.396) had a significantly lower risk for development of hypertriglyceridemia compared to the reference group (P trend<0.001). Participants in the highest tertile of serum ghrelin had a significant lower risk of hypertriglyceridemia, hyperglycemia, low HDL-C, and MetS (Ptrend<0.05). Women who were in the higher tertile of serum NGF levels had a significantly lower risk for development of hypertriglyceridemia after adjustment for potential confounding variables (OR=0.091, 95% CI: 0.023-0.361 and OR=0.193, 95% CI: 0.057-0.649 respectively). Conclusion: In the current study serum levels of obestatin, NGF, and ghrelin were associated with some cardio-metabolic risk factors such as hypertriglyceridemia and MetS. It seems that these factors are associated with metabolic regulation. However, further studies are needed to substantiate this claim.

show abstract